scholarly journals Guava leaf extract suppresses osteoarthritis progression in a rat anterior cruciate ligament transection model

2018 ◽  
Vol 6 (4) ◽  
pp. 800-805 ◽  
Author(s):  
Keiko Kawasaki ◽  
Takashi Fushimi ◽  
Junji Nakamura ◽  
Noriyasu Ota
Keyword(s):  
Anterior Cruciate Ligament ◽  
Leaf Extract ◽  
Cruciate Ligament ◽  
Anterior Cruciate Ligament Transection ◽  
Osteoarthritis Progression ◽  
Anterior Cruciate ◽  
Guava Leaf

Influence of age on osteoarthritis progression after anterior cruciate ligament transection in rats

2014 ◽  
Vol 55 ◽  
pp. 44-48 ◽  
Author(s):  
María Luisa Ferrándiz ◽  
María Carmen Terencio ◽  
Ramón Ruhí ◽  
Josep Vergés ◽  
Eulàlia Montell ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Cruciate Ligament ◽  
Anterior Cruciate Ligament Transection ◽  
Osteoarthritis Progression ◽  
Anterior Cruciate

scholarly journals Comparison of pain behaviour and osteoarthritis progression between anterior cruciate ligament transection and osteochondral injury in rat models

2018 ◽  
Vol 7 (3) ◽  
pp. 244-251 ◽  
Author(s):  
T. Tawonsawatruk ◽  
O. Sriwatananukulkit ◽  
W. Himakhun ◽  
W. Hemstapat
Keyword(s):  
Anterior Cruciate Ligament ◽  
Cruciate Ligament ◽  
Histological Evaluation ◽  
Anterior Cruciate Ligament Transection ◽  
Pain Behaviour ◽  
Rat Models ◽  
Injury Model ◽  
Osteochondral Injury ◽  
Osteoarthritis Progression ◽  
Anterior Cruciate

Objectives In this study, we compared the pain behaviour and osteoarthritis (OA) progression between anterior cruciate ligament transection (ACLT) and osteochondral injury in surgically-induced OA rat models. Methods OA was induced in the knee joints of male Wistar rats using transection of the ACL or induction of osteochondral injury. Changes in the percentage of high limb weight distribution (%HLWD) on the operated hind limb were used to determine the pain behaviour in these models. The development of OA was assessed and compared using a histological evaluation based on the Osteoarthritis Research Society International (OARSI) cartilage OA histopathology score. Results Both models showed an increase in joint pain as indicated by a significant (p < 0.05) decrease in the values of %HLWD at one week post-surgery. In the osteochondral injury model, the %HLWD returned to normal within three weeks, while in the ACLT model, a significant decrease in the %HLWD was persistent over an eight-week period. In addition, OA progression was more advanced in the ACLT model than in the osteochondral injury model. Furthermore, the ACLT model exhibited a higher mean OA score than that of the osteochondral injury model at 12 weeks. Conclusion The development of pain patterns in the ACLT and osteochondral injury models is different in that the OA progression was significant in the ACLT model. Although both can be used as models for a post-traumatic injury of the knee, the selection of appropriate models for OA in preclinical studies should be specified and relevant to the clinical scenario. Cite this article: T. Tawonsawatruk, O. Sriwatananukulkit, W. Himakhun, W. Hemstapat. Comparison of pain behaviour and osteoarthritis progression between anterior cruciate ligament transection and osteochondral injury in rat models. Bone Joint Res 2018;7:244–251. DOI: 10.1302/2046-3758.73.BJR-2017-0121.R2.

scholarly journals High-resolution MRI and micro-CT in an ex vivo rabbit anterior cruciate ligament transection model of osteoarthritis

2004 ◽  
Vol 12 (8) ◽  
pp. 614-626 ◽  
Author(s):  
Danika L. Batiste ◽  
Alexandra Kirkley ◽  
Sheila Laverty ◽  
Lisa M.F. Thain ◽  
Alison R. Spouge ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
High Resolution ◽  
Ex Vivo ◽  
Cruciate Ligament ◽  
Micro Ct ◽  
Anterior Cruciate Ligament Transection ◽  
High Resolution Mri ◽  
Anterior Cruciate

scholarly journals Effects of BIS076 in a model of osteoarthritis induced by anterior cruciate ligament transection in ovariectomised rats

2015 ◽  
Vol 16 (1) ◽  
Author(s):  
María Luisa Ferrándiz ◽  
María Carmen Terencio ◽  
María Carmen Carceller ◽  
Ramón Ruhí ◽  
Pere Dalmau ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Cruciate Ligament ◽  
Anterior Cruciate Ligament Transection ◽  
Anterior Cruciate ◽  
Ovariectomised Rats

scholarly journals Anterior Cruciate Ligament Rupture and Osteoarthritis Progression

2012 ◽  
Vol 6 (1) ◽  
pp. 295-300 ◽  
Author(s):  
James Min-Leong Wong ◽  
Tanvir Khan ◽  
Chethan S Jayadev ◽  
Wasim Khan ◽  
David Johnstone
Keyword(s):  
Anterior Cruciate Ligament ◽  
Acl Reconstruction ◽  
Cruciate Ligament ◽  
Degenerative Change ◽  
Acl Rupture ◽  
Osteoarthritis Progression ◽  
Anterior Cruciate ◽  
The Relationship ◽  
Meniscal Damage ◽  
Acl Deficient

Anterior Cruciate Ligament (ACL) rupture is a common sporting injury that frequently affects young, athletic patients. Apart from the functional problems of instability, patients with ACL deficient knees also develop osteoarthritis. Although this is frequently cited as an indication for ACL reconstruction, the relationship between ACL rupture, reconstruction and the instigation and progression of articular cartilage degenerative change is controversial. The purpose of this paper is to review the published literature with regards ACL rupture and the multifactorial causes for osteoarthritis progression, and whether or not this is slowed or stopped by ACL reconstruction. There is no evidence in the published literature to support the view that ACL reconstruction prevents osteoarthritis, although it may prevent further meniscal damage. It must be recognised that this conclusion is based on the current literature which has substantial methodological limitations.

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