scholarly journals Effects of confinement on the mechanical properties of self-assembled articular cartilage constructs in the direction orthogonal to the confinement surface

2007 ◽  
Vol 26 (2) ◽  
pp. 238-246 ◽  
Author(s):  
Benjamin D. Elder ◽  
Kyriacos A. Athanasiou
Keyword(s):  
Mechanical Properties ◽  
Articular Cartilage ◽  
Self Assembled

scholarly journals Non‐destructive detection of matrix stabilization correlates with enhanced mechanical properties of self‐assembled articular cartilage

2019 ◽  
Vol 13 (4) ◽  
pp. 637-648 ◽  
Author(s):  
Anne K. Haudenschild ◽  
Benjamin E. Sherlock ◽  
Xiangnan Zhou ◽  
Jerry C. Hu ◽  
J. Kent Leach ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Articular Cartilage ◽  
Matrix Stabilization ◽  
Self Assembled ◽  
Non Destructive

Effect of Compressive Load on the Mechanical Property of a Stem Cell Based Self-Assembled Tissue Derived From Synovium

2009 ◽  
Author(s):  
Ryo Emura ◽  
Atsushi Ogawa ◽  
Kei Saito ◽  
Wataru Ando ◽  
Norimasa Nakamura ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Mechanical Property ◽  
Stem Cell ◽  
Articular Cartilage ◽  
Compressive Load ◽  
Static Compression ◽  
Cartilage Injuries ◽  
Immunological Effects ◽  
Self Assembled

Articular cartilage has superior functions such as impact absorption and low friction, although their healing capacities are limited. It is one of potential options for the repair of articular cartilage to use cell-based therapies. We have been developing a novel tissue-engineering technique for the repair of cartilage which involves a stem cell-based self-assembled tissue (scSAT) derived from synovium. As the scSAT is a scaffold-free contrust composed of cells with their native extracellular matrix, it is free from concern regarding long-term immunological effects. The scSAT is expressed as tissue engineered construct (TEC) when it is used for cartilage repair. Previous studies indicated that the mechanical properties of cartilage-like tissues repaired using the scSAT were slightly inferiorer to those of normal cartilage. We have a hypothesis that the mechanical properties of the cartilage-like tissues are improved if the scSAT is subjected to an adequate compressive stimulation in vitro before implantation. The present study was conducted as a preliminary study to determine whether static compression improves the mechanical property of the scSAT for more advanced regenerative medicine to cartilage injuries and degeneration.

Sequential changes in the mechanical properties of viable articular cartilage storedin vitro

1984 ◽  
Vol 2 (1) ◽  
pp. 55-60 ◽  
Author(s):  
Victor J. Thomas ◽  
Sergio A. Jimenez ◽  
Carl T. Brighton ◽  
Norman Brown
Keyword(s):  
Mechanical Properties ◽  
Articular Cartilage

Transversely isotropic micromechanics model to determine effect of collagen fibre angle in mechanical properties of articular cartilage

2014 ◽  
Vol 29 (6) ◽  
pp. 377-383 ◽  
Author(s):  
S. Mohammad Mehdi Elhamian ◽  
M. Alizadeh ◽  
M. Mehrdad Shokrieh ◽  
A. Karimi ◽  
S. Pejman Madani
Keyword(s):  
Mechanical Properties ◽  
Articular Cartilage ◽  
Collagen Fibre ◽  
Transversely Isotropic ◽  
Micromechanics Model ◽  
Fibre Angle ◽  
Determine Effect

Permeability of Human Glenohumeral Joint Cartilage

1999 ◽  
Author(s):  
Anna Stankiewicz ◽  
Gerard A. Ateshian ◽  
Louis U. Bigliani ◽  
Van C. Mow
Keyword(s):  
Mechanical Properties ◽  
Articular Cartilage ◽  
Interstitial Fluid ◽  
Glenohumeral Joint ◽  
Solid Matrix ◽  
Joint Cartilage ◽  
Frictional Drag ◽  
Diarthrodial Joints ◽  
Flow Through ◽  
Fluid Pressurization

Abstract The nearly frictionless lubrication in diarthrodial joints and load support within articular cartilage depends on its mechanical properties. It has been shown that the majority of applied loads on cartilage are supported by interstitial fluid pressurization (Ateshian et al., 1994) which results from the frictional drag of flow through the porous permeable solid matrix. The duration and magnitude of this pressurization are a function of the permeability of cartilage (Lai et al., 1981).

Simultaneous changes in the mechanical properties, quantitative collagen organization, and proteoglycan concentration of articular cartilage following canine meniscectomy

2000 ◽  
Vol 18 (3) ◽  
pp. 383-392 ◽  
Author(s):  
Michelle A. LeRoux ◽  
Jari Arokoski ◽  
T. Parker Vail ◽  
Farshid Guilak ◽  
Mika M. Hyttinen ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Articular Cartilage ◽  
Collagen Organization

Exercise Affects the Mechanical Properties and Histological Appearance of Equine Articular Cartilage

2000 ◽  
Vol 82 (8) ◽  
pp. 48
Author(s):  
R. C. Murray ◽  
C. F. Zhu ◽  
A. E. Goodship ◽  
K. H. Lakhani ◽  
C. M. Agrawal ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Articular Cartilage ◽  
Histological Appearance
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