scholarly journals Validation of an in vitro single-impact load model of the initiation of osteoarthritis-like changes in articular cartilage

2006 ◽  
Vol 24 (4) ◽  
pp. 725-732 ◽  
Author(s):  
Camille A.M. Huser ◽  
M. Elisabeth Davies
Keyword(s):  
Articular Cartilage ◽  
Impact Load ◽  
Load Model ◽  
Single Impact

Mechanical Loading Reduces Chondrocyte Death After Single Impact Trauma: Porcine Knee Model

2012 ◽  
Author(s):  
Lauren L. Vernon ◽  
David G. Wilensky ◽  
Chong Wang ◽  
Lee D. Kaplan ◽  
Chun-Yuh C. Huang
Keyword(s):  
Articular Cartilage ◽  
Mechanical Loading ◽  
Motor Vehicle ◽  
Degenerative Changes ◽  
Matrix Composition ◽  
Single Impact ◽  
Knee Model ◽  
Chondrocyte Death ◽  
Porcine Knee

Osteoarthritis often results from degenerative changes induced by trauma such as joint impact injuries sustained during athletics, combat, or motor vehicle accidents. Articular cartilage, avascular in nature, relies of synovial nutrition [1] and lacks sufficient regenerative capabilities [2]. Acute cartilage injuries have been shown to induce cell death [3, 4, 5], leading to reduced chondrocyte density and degenerative changes to the cartilage matrix composition; over time the tissue becomes compromised and loses its ability to maintain and restore itself. It has been demonstrated, that mechanical loading can affect local perfusion and diffusion through the matrix thereby altering the flow of nutrients and metabolites [2, 6]. Furthermore, mechanical loading modulates the chondrocyte biosynthesis of extracellular matrix that is required in the cartilage repair process. In this study, a two part in-vitro porcine knee model was utilized to investigate articular cartilage response immediately following a single impact injury under cyclic mechanical loading conditions.

scholarly journals The effect of recombinant human fibroblast growth factor-18 on articular cartilage following single impact load

2014 ◽  
Vol 32 (7) ◽  
pp. 923-927 ◽  
Author(s):  
Lynne Barr ◽  
Alan Getgood ◽  
Hans Guehring ◽  
Neil Rushton ◽  
Frances M. D. Henson
Keyword(s):  
Articular Cartilage ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Human Fibroblast ◽  
Impact Load ◽  
Fibroblast Growth ◽  
Single Impact
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