Neuroimmunological complications arising from chemotherapy‐induced gut toxicity and opioid exposure in female dark agouti rats

2021 ◽  
Author(s):  
Juliana Esma Bajic ◽  
Gordon Stanley Howarth ◽  
Suzanne Mashtoub ◽  
Alexandra Louise Whittaker ◽  
Larisa Bobrovskaya ◽  
...  
Keyword(s):  
Dark Agouti ◽  
Gut Toxicity

scholarly journals Glutathione Conjugates of Ochratoxin a as Biomarkers of Exposure / Glutationski Konjugati Okratoksina A Kao Biomarkeri Izloženosti

2012 ◽  
Vol 63 (4) ◽  
pp. 417-427 ◽  
Author(s):  
Mariana Tozlovanu ◽  
Delphine Canadas ◽  
Annie Pfohl-Leszkowicz ◽  
Christine Frenette ◽  
Robert J. Paugh ◽  
...  
Keyword(s):  
Ochratoxin A ◽  
Rat Kidney ◽  
Female Rats ◽  
Amide Bond ◽  
Male Rats ◽  
Dark Agouti ◽  
Female Rat ◽  
Male And Female ◽  
Male And Female Rats ◽  
Liver And Kidney

AbstractIn the present study the photoreactivity of the fungal carcinogen ochratoxin A (OTA) has been utilised to generate authentic samples of reduced glutathione (GSH) and N-acetylcysteine (NAC) conjugates of the parent toxin. These conjugates, along with the nontoxic OTα, which is generated through hydrolysis of the amide bond of OTA by carboxypeptidase A, were utilised as biomarkers to study the metabolism of OTA in the liver and kidney of male and female Dark Agouti rats. Male rats are more susceptible than female rats to OTA carcinogenesis with the kidney being the target organ. Our studies show that the distribution of OTA in male and female rat kidney is not significantly different. However, the extent of OTA metabolism was greater in male than female rats. Much higher levels of OTα were detected in the liver compared to the kidney, and formation of OTα is a detoxification pathway for OTA. These findings suggest that differences in metabolism between male and female rats could provide an explanation for the higher sensitivity of male rats to OTA toxicity

Uptake, fate, and gut toxicity of perfluorooctanoic acid (PFOA) in vitro

2021 ◽  
Vol 350 ◽  
pp. S231
Author(s):  
M. Leveque ◽  
C. Stoffels ◽  
E. Person ◽  
I. Fourquaux ◽  
V. Theodorou ◽  
...  
Keyword(s):  
Perfluorooctanoic Acid ◽  
Gut Toxicity

PERHEXILINE-INDUCED LIPIDOSIS IN THE DARK AGOUTI (DA) RAT

Brain ◽  
1986 ◽  
Vol 109 (4) ◽  
pp. 649-660 ◽  
Author(s):  
CLAUS MEIER ◽  
AXEL WAHLLAENDER ◽  
CHRISTIAN W. HESS ◽  
RUDOLF PREISIG
Keyword(s):  
Dark Agouti

Dextrorotatory opioids induce stereotyped behavior in Sprague-Dawley and Dark Agouti rats

1998 ◽  
Vol 140 (2) ◽  
pp. 206-216 ◽  
Author(s):  
J. E. Ishmael ◽  
P. H. Franklin ◽  
T. F. Murray
Keyword(s):  
Stereotyped Behavior ◽  
Dark Agouti ◽  
Sprague Dawley
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