Dextrorotatory opioids induce stereotyped behavior in Sprague-Dawley and Dark Agouti rats

1998 ◽  
Vol 140 (2) ◽  
pp. 206-216 ◽  
Author(s):  
J. E. Ishmael ◽  
P. H. Franklin ◽  
T. F. Murray
Keyword(s):  
Stereotyped Behavior ◽  
Dark Agouti ◽  
Sprague Dawley

Comparison of CYP2D metabolism and hepatotoxicity of the myocardial metabolic agent perhexiline in Sprague–Dawley and Dark Agouti rats

Xenobiotica ◽  
2014 ◽  
Vol 45 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Giovanni Licari ◽  
Andrew A. Somogyi ◽  
Robert W. Milne ◽  
Benedetta C. Sallustio
Keyword(s):  
Dark Agouti ◽  
Sprague Dawley

Sodium chloride preference of genetically hypertensive and normotensive rats

1983 ◽  
Vol 245 (1) ◽  
pp. R38-R44 ◽  
Author(s):  
R. Di Nicolantonio ◽  
F. A. Mendelsohn ◽  
J. S. Hutchinson
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rat ◽  
Sodium Intake ◽  
Bb Rat ◽  
Dark Agouti ◽  
Sprague Dawley ◽  
Saline Preference ◽  
Wistar Kyoto ◽  
Preference Tests ◽  
Genetically Hypertensive

Preference for 0.9% saline was examined, using two-bottle preference tests over 6-7 days, in the spontaneously hypertensive rat (SHR) and normotensive Wistar Kyoto rat (WK) of the Okamoto strain, the genetically hypertensive (GHR) and normotensive rat (NT) of the Smirk strain, and the Sprague-Dawley (SD), Dark Agouti (DA), and hooded Long-Evans or Brattleboro (BB) rat. Only the SHR exhibited a sustained and marked preference for 0.9% saline on each test day. The WK, GHR, NT, and SD preferred saline in the first 24-48 h of testing but thereafter showed neither a preference for, nor aversion to, saline. The BB showed neither a preference for, nor aversion to, saline in the first 24 h of testing and thereafter showed a significant aversion to saline on each test day. Saline preference was further examined in both the SHR and WK offered a choice of water and 0.9%, 2.0, or 2.7% saline. While preference for saline decreased in both SHR and WK with increasing saline concentration, the SHR maintained a significantly greater preference for saline and greater total sodium intake than the WK at each concentration. Hydralazine (5 mg . kg-1 . day-1, po) administered to SHR, while they were offered a choice of water and 0.9% saline, significantly lowered blood pressure over a 4-day period but failed to alter their saline preference significantly. We conclude that of the seven strains of rats examined only the SHR exhibited a preference for saline in extended two-bottle preference tests. Furthermore this preference for saline appears to be maintained independently of the blood pressure of the SHR.

Acute Toxicity of 3,4-Methylenedioxymethamphetamine (MDMA) in Sprague–Dawley and Dark Agouti Rats

1999 ◽  
Vol 64 (1) ◽  
pp. 29-34 ◽  
Author(s):  
A Malpass ◽  
J.M White ◽  
R.J Irvine ◽  
A.A Somogyi ◽  
F Bochner
Keyword(s):  
Acute Toxicity ◽  
Dark Agouti ◽  
Sprague Dawley

Developmental Regulation of Codeine Analgesia in the Rat

2004 ◽  
Vol 100 (1) ◽  
pp. 92-97 ◽  
Author(s):  
D. Glyn Williams ◽  
Anthony Dickenson ◽  
Maria Fitzgerald ◽  
Richard F. Howard
Keyword(s):  
Developmental Regulation ◽  
Postnatal Period ◽  
Poor Metabolizers ◽  
Dark Agouti ◽  
Mechanical Stimuli ◽  
Sprague Dawley ◽  
Adult Rats ◽  
Noxious Heat ◽  
Age Related ◽  
Old Rats

Background Codeine analgesia is dependent on metabolism to morphine. Metabolic capability is genetically determined in rats and humans, and individuals can be classified as extensive or poor metabolizers, as determined by the extent of production of morphine. Codeine is often given to infants and children. The aim of this study was to investigate the effects of developmental age on codeine analgesia in rats. Methods The effects of codeine were compared with those of morphine using withdrawal reflex responses to mechanical stimuli (with and without inflammation) and to noxious heat in two strains of rats (Sprague-Dawley and Dark Agouti) that have been used to model human metabolic phenotypes because of marked differences in enzyme activity. Effects of the opioids were compared at 3, 10, and 21 days of age and in adult rats. Results Consistent age-related changes in the efficacy of codeine relative to morphine were noted for both strains of rats. For the extensive metabolizer (Sprague-Dawley) strain, codeine efficacy was substantially lower at 3 days of age (P < 0.001), but there was no difference between the effects of codeine and morphine for 10- and 21-day-old rats and adults (P > 0.05). Poor metabolizers (Dark Agouti strain) also had comparatively low efficacy for codeine compared with morphine in 3-day-old rats and in adults (P < 0.001). In 10- and 21-day-old Dark Agouti rats, there was no difference between either drug (P < 0.05). Conclusions Codeine analgesia is developmentally regulated, with low efficacy in the early postnatal period. Effects in the adult rat were not predictive of efficacy in development in either strain, which has important implications for further study and, possibly, for clinical use.

scholarly journals DIFFERENCES IN ADRENAL MORPHOLOGY IN MALE DARK AGOUTI, SPRAGUE-DAWLEY AND WISTAR RATS

1999 ◽  
Vol 47 (3) ◽  
pp. 335-339 ◽  
Author(s):  
Jenny M. Wilkinson ◽  
S. Halley ◽  
P. A. Towers
Keyword(s):  
Wistar Rats ◽  
Adrenal Glands ◽  
Volume Fraction ◽  
Single Species ◽  
The Other ◽  
Dark Agouti ◽  
Sprague Dawley ◽  
Zona Reticularis ◽  
Functional Differences ◽  
Morphological Differences

There is little published information describing the differences in adrenal structure between strains of a single species despite quite well known functional differences. In this paper we report morphological differences in the adrenal glands between three strains of laboratory rat; Dark Agouti (DA), Sprague-Dawley (SD) and Wistar (W). Significant differences in adrenal weights (as a percentage of body weight) were not detected between any of the groups. While there were no significant differences in the volume of medullary or zonae glomerulosa or fasciculata tissue, the volume fraction for the zona reticularis was significantly smaller in DAs compared to the other strains. The functional significance of these differences is unknown. However, it is suggested that the reduced volume of zona reticularis tissue may contribute to a reduced capacity for glucocorticoid synthesis or storage.

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