Outcome measures from experimental traumatic brain injury in male rats vary with the complete temporal biomechanical profile of the injury event

2020 ◽  
Vol 98 (10) ◽  
pp. 2027-2044
Author(s):  
Radia Abdul‐Wahab ◽  
Mathew T. Long ◽  
Rafael Ordaz ◽  
Bruce G. Lyeth ◽  
Bryan J. Pfister
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Outcome Measures ◽  
Male Rats ◽  
Injury Event ◽  
Experimental Traumatic Brain Injury

Clinically Relevant Outcome Measures for Experimental Traumatic Brain Injury (TBI) Studies

2019 ◽  
pp. 263-294
Author(s):  
Denes V. Agoston ◽  
Jesse McCullough ◽  
Roxanne Aniceto ◽  
Alaa Kamnaksh ◽  
David K. Wright ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Outcome Measures ◽  
Experimental Traumatic Brain Injury ◽  
Relevant Outcome

scholarly journals The level of oxidative stress in rat brain tissue after a brain trauma injury with introduction of synthetic regulatory peptides

2020 ◽  
pp. 65-67
Author(s):  
A. A. Kolesnikova ◽  
M. Yu. Fleishman ◽  
N. Yu. Yakusheva ◽  
E. V. Slobodenyuk ◽  
I. V. Tolstenok
Keyword(s):  
Oxidative Stress ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Tissue ◽  
Regulatory Peptides ◽  
Antioxidant Effect ◽  
Male Rats ◽  
The Third ◽  
Trauma Injury ◽  
Experimental Traumatic Brain Injury

Objective: Comparative evaluation of the effect of regulatory peptides on lipid peroxidation in brain tissue after traumatic brain injury (TBI).Methods: Reproductive Wistar male rats were divided into 3 groups: the first group received 0.1 mg/kg of “Selang” peptide solution (Thy-Lys-Pro-Arg-Pro-Gly-Pro) within 5 days after the experimental traumatic brain injury, the second group received 0.1 mg/kg AGAPGP peptide (Arg-Gly-Arg-Pro-Gly-Pro), the third (control) – 0.9% sodium chloride solution. Drugs were administered retroperitoneally.Results: According to chemiluminescence in the biomaterial taken from rats of the first group, indicators of oxidative stress were less pronounced.Conclusions: The Selang has a more pronounced antioxidant effect on brain tissue after traumatic brain injury compared with the AGAPGP peptide. 

Comparison of Seven Anesthetic Agents on Outcome after Experimental Traumatic Brain Injury in Adult, Male Rats

2006 ◽  
Vol 23 (1) ◽  
pp. 97-108 ◽  
Author(s):  
Kimberly D. Statler ◽  
Henry Alexander ◽  
Vincent Vagni ◽  
C. Edward Dixon ◽  
Robert S.B. Clark ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Adult Male ◽  
Male Rats ◽  
Anesthetic Agents ◽  
Experimental Traumatic Brain Injury

scholarly journals THE SEARCH FOR NEUROPROTECTIVE COMPOUNDS AMONG NEW ETHYLTHIADIAZOLE DERIVATIVES

2021 ◽  
Vol 8 (4) ◽  
pp. 263-272
Author(s):  
R. F. Cherevatenko ◽  
O. V. Antsiferov ◽  
S. Y. Skachilova ◽  
M. V. Pokrovsky ◽  
V. V. Gureev ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Male ◽  
Male Rats ◽  
Control Group ◽  
Rota Rod Test ◽  
Neurological Research ◽  
Pharmacological Screening ◽  
Sexually Mature ◽  
Experimental Traumatic Brain Injury

The aim of the study is to search compounds with neuroprotective properties among new ethylthiadiazole derivatives in simulated traumatic brain injury.Materials and methods. The experiment was carried out on 78 white male rats 270±20 g line “Wistar” 5–6 months of age and 120 outbred sexually mature mice weighing 20±2 grams. The article describes the search for compounds with neuroprotective properties among new ethylthiadiazole derivatives under the codes LKHT 4–15, LKHT 10–18, LKHT 11–18, and LKHT 12–18 in experimental traumatic brain injury in rats. Acute toxicity of the compounds was studied. Pharmacological screening was performed using behavioral and neurological research methods. The McGraw stroke score scale modified by I.V. Gannushkina and the mNSS psychometric scale were used in the study. The open field and Rota-rod tests were used to assess the behavioral status of the animals.Results. The compound-LKHT 12–18 at a dose of 50 mg/kg was detected as a leader. In pharmacological correction of pathology, this compound had the lowest percentage of fatality among the studied compounds (8%), the severity of neurological deficit was significantly reduced, the lowest scores and a higher level of motor activity of the limbs were registered. The number of rearing in the group of animals receiving the compound LKHT 12–18 at the dose of 50 mg/kg increased by 1.5 times, statistically significant (p<0.05) in comparison with the control group. Based on the results of the “Rota-rod” test, the total time of holding animals on the rod for 3 attempts was statistically significantly different in the groups administered with LKHT 12–18 derivatives (1.5 times longer) at the dose of 50 mg/kg compared with the control (p<0.05).Conclusion. Based on the results obtained in this study, it is planned to study in more detail the compound LKHT 12–18 at the dose of 50 mg/kg.

scholarly journals Changes in Neuropeptide Y after Experimental Traumatic Brain Injury in the Rat

1992 ◽  
Vol 12 (4) ◽  
pp. 697-702 ◽  
Author(s):  
Tracy K. McIntosh ◽  
Donna Ferriero
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Neuropeptide Y ◽  
Parietal Cortex ◽  
Brain Regions ◽  
Male Rats ◽  
Post Injury ◽  
Regional Brain ◽  
Left Parietal Cortex ◽  
Experimental Traumatic Brain Injury

We utilized a model of fluid percussion (FP) brain injury in the rat to examine the hypothesis that alterations in brain neuropeptide Y (NPY) concentrations occur following brain injury. Male rats (n = 44) were subjected to FP traumatic brain injury. One group of animals (n = 38) was killed at 1 min, 15 min, 1 h, or 24 h after brain injury, and regional brain homogenates were analyzed for NPY concentrations using radioimmunoassay. A second group of animals (n = 6) was killed for NPY immunocytochemistry. Concentrations of NPY in the injured left parietal cortex were significantly elevated at 15 min post injury (p < 0.05). No changes were observed in other brain regions. NPY-immunoreactive fibers were seen at 15 min post injury predominantly in the injured cortex and adjacent hippocampus. These temporal changes in NPY immunoreactivity, together with previous observations concerning posttraumatic changes in regional CBF in these same areas, suggest that an increase in region NPY concentrations after brain injury may be involved in part in the pathogenesis of posttraumatic hypoperfusion.

scholarly journals Enriching neural stem cell and anti‐inflammatory glial phenotypes with electrical stimulation after traumatic brain injury in male rats

2021 ◽  
Author(s):  
Eunyoung Park ◽  
Johnathan G. Lyon ◽  
Melissa Alvarado‐Velez ◽  
Martha I. Betancur ◽  
Nassir Mokarram ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cell ◽  
Electrical Stimulation ◽  
Brain Injury ◽  
Neural Stem Cell ◽  
Male Rats ◽  
Anti Inflammatory
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