Rare variants and biological pathways identified in treatment‐refractory depression

2020 ◽  
Vol 98 (7) ◽  
pp. 1322-1334
Author(s):  
Lora Lee McClain ◽  
Patricia Shaw ◽  
Roisin Sabol ◽  
Anna Maria Chedia ◽  
Anna Maria Segretti ◽  
...  
Keyword(s):  
Rare Variants ◽  
Biological Pathways ◽  
Refractory Depression ◽  
Treatment Refractory

Author response for "Rare variants and biological pathways identified in treatment‐refractory depression"

2020 ◽  
Author(s):  
Lora Lee McClain ◽  
Patricia Shaw ◽  
Roisin Sabol ◽  
Anna Maria Chedia ◽  
Anna Maria Segretti ◽  
...  
Keyword(s):  
Rare Variants ◽  
Biological Pathways ◽  
Author Response ◽  
Refractory Depression ◽  
Treatment Refractory

Author response for "Rare variants and biological pathways identified in treatment‐refractory depression"

2020 ◽  
Author(s):  
Lora Lee McClain ◽  
Patricia Shaw ◽  
Roisin Sabol ◽  
Anna Maria Chedia ◽  
Anna Maria Segretti ◽  
...  
Keyword(s):  
Rare Variants ◽  
Biological Pathways ◽  
Author Response ◽  
Refractory Depression ◽  
Treatment Refractory

scholarly journals Accidental chronic lithium toxicity

2018 ◽  
Vol 7 (12) ◽  
pp. 2456
Author(s):  
Vangelis George Kanellis ◽  
Ramila Varendran
Keyword(s):  
Serum Levels ◽  
Endocrine Function ◽  
Lithium Toxicity ◽  
First Line ◽  
Salt Restriction ◽  
Refractory Depression ◽  
Prevention Studies ◽  
Disorder Treatment ◽  
Treatment Refractory ◽  
Nomadic Life

Lithium is an effective first-line mood stabiliser for bipolar disorder, treatment-refractory depression and suicide prevention. Studies have demonstrated its ability to produce neuroprotective benefits. Despite this, Lithium can cause neurotoxicity, cardiotoxicity and endocrine derangement resulting in severe (and potentially permanent) side effects. Lithium toxicity can be precipitated by illness, salt restriction diets, dehydration, nephrogenic diabetes insipidus, impaired creatinine clearance, concomitant drugs. This is particularly true in older patients with altered pharmacodynamics and pharmacokinetics. We present a 52-year-old female who presented with prolonged signs of lithium toxicity post-diarrhoea. Lack of monitoring due to her nomadic life-style resulted in the combination of long-lasting neurotoxicity and thyroid dysfunction. Our patient displayed neurotoxicity that was not present on imaging. This highlights the importance of regular monitoring of renal function, lithium serum levels and neuro-endocrine function to reduce complications associated with lithium toxicity.

scholarly journals Long term outcome of thermal anterior capsulotomy for chronic, treatment refractory depression

2010 ◽  
Vol 82 (6) ◽  
pp. 594-600 ◽  
Author(s):  
D. Christmas ◽  
M. S. Eljamel ◽  
S. Butler ◽  
H. Hazari ◽  
R. MacVicar ◽  
...  
Keyword(s):  
Chronic Treatment ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Refractory Depression ◽  
Treatment Refractory ◽  
Anterior Capsulotomy

Deep Brain Stimulation for Treatment-Refractory Depression—Part I

2014 ◽  
Vol 36 (14) ◽  
pp. 1-5
Author(s):  
Purushottam B. Thapa ◽  
Faiza A. Khan ◽  
Erika Petersen ◽  
Sushma Thapa
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Refractory Depression ◽  
Treatment Refractory ◽  
Deep Brain
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