Development of resurgent and persistent sodium currents in mesencephalic trigeminal neurons

2017 ◽  
Vol 96 (2) ◽  
pp. 305-312 ◽  
Author(s):  
Akifumi Enomoto ◽  
Soju Seki ◽  
Susumu Tanaka ◽  
Kohji Ishihama ◽  
Tadashi Yamanishi ◽  
...  
Keyword(s):  
Sodium Currents ◽  
Trigeminal Neurons ◽  
Mesencephalic Trigeminal Neurons

Sodium Currents in Mesencephalic Trigeminal Neurons From Nav1.6 Null Mice

2007 ◽  
Vol 98 (2) ◽  
pp. 710-719 ◽  
Author(s):  
Akifumi Enomoto ◽  
Juliette M. Han ◽  
Chie-Fang Hsiao ◽  
Scott H. Chandler
Keyword(s):  
Membrane Properties ◽  
Sodium Currents ◽  
Wild Type ◽  
Spike Discharge ◽  
Subthreshold Oscillations ◽  
Trigeminal Neurons ◽  
Membrane Resonance ◽  
Mesencephalic Trigeminal Neurons ◽  
Frequency Relationship ◽  
Resurgent Sodium Currents

Previous studies using pharmacological methods suggest that subthreshold sodium currents are critical for rhythmical burst generation in mesencephalic trigeminal neurons (Mes V). In this study, we characterized transient ( INaT), persistent ( INaP), and resurgent ( Ires) sodium currents in Nav1.6-null mice ( med mouse, Nav1.6−/−) lacking expression of the sodium channel gene Scn8a. We found that peak transient, persistent, and resurgent sodium currents from med (Nav1.6−/−) mice were reduced by 18, 39, and 76% relative to their wild-type (Nav1.6+/+) littermates, respectively. Current clamp recordings indicated that, in response to sinusoidal constant amplitude current (ZAP function), all neurons exhibited membrane resonance. However, Mes V neurons from med mice had reduced peak amplitudes in the impedance-frequency relationship (resonant Q-value) and attenuated subthreshold oscillations despite the similar passive membrane properties compared with wild-type littermates. The spike frequency-current relationship exhibited reduced instantaneous discharge frequencies and spike block at low stimulus currents and seldom showed maintained spike discharge throughout the stimulus in the majority of med neurons compared with wild-type neurons. Importantly, med neurons never exhibited maintained stimulus-induced rhythmical burst discharge unlike those of wild-type littermates. The data showed that subthreshold sodium currents are critical determinants of Mes V electrogenesis and burst generation and suggest a role for resurgent sodium currents in control of spike discharge.

Arrangement and Connections of Mesencephalic Trigeminal Neurons in the Rat

1986 ◽  
Vol 127 (1) ◽  
pp. 7-15 ◽  
Author(s):  
J.T.M. Rokx ◽  
P.J.W. Jüch ◽  
J.D. van Willigen
Keyword(s):  
Trigeminal Neurons ◽  
Mesencephalic Trigeminal Neurons

Effect of allapinine on sodium currents in single trigeminal neurons and cardiomyocytes of rats

1991 ◽  
Vol 111 (4) ◽  
pp. 496-498 ◽  
Author(s):  
A. E. Valeev ◽  
A. N. Verkhratskii ◽  
F. N. Dzhakhangirov
Keyword(s):  
Sodium Currents ◽  
Trigeminal Neurons
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