Dexamethasone reduces brain cell apoptosis and inhibits inflammatory response in rats with intracerebral hemorrhage

2014 ◽  
Vol 93 (1) ◽  
pp. 178-188 ◽  
Author(s):  
I-Neng Lee ◽  
Wan-Chun Cheng ◽  
Chiu-Yen Chung ◽  
Ming-Hsueh Lee ◽  
Martin Hsiu-Chu Lin ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Intracerebral Hemorrhage ◽  
Cell Apoptosis ◽  
Brain Cell

scholarly journals Retraction: Salvianolic acid B inhibits inflammatory response and cell apoptosis via the PI3K/Akt signaling pathway in IL-1β-induced osteoarthritis chondrocytes

RSC Advances ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 4441-4441
Author(s):  
Laura Fisher
Keyword(s):  
Inflammatory Response ◽  
Signaling Pathway ◽  
Cell Apoptosis ◽  
Akt Signaling ◽  
Salvianolic Acid B ◽  
Signalling Pathway ◽  
Akt Signaling Pathway ◽  
Salvianolic Acid ◽  
Osteoarthritis Chondrocytes

Retraction of ‘Salvianolic acid B inhibits inflammatory response and cell apoptosis via the PI3K/Akt signalling pathway in IL-1β-induced osteoarthritis chondrocytes’ by Bin Zhu et al., RSC Adv., 2018, 8, 36422–36429, DOI: 10.1039/C8RA02418A.

scholarly journals Long non-coding RNA OIP5-AS1 aggravates acute lung injury by promoting inflammation and cell apoptosis via regulating the miR-26a-5p/TLR4 axis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Qingsong Sun ◽  
Man Luo ◽  
Zhiwei Gao ◽  
Xiang Han ◽  
Weiqin Wu ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Inflammatory Response ◽  
Cell Apoptosis ◽  
Quantitative Polymerase Chain Reaction ◽  
Luciferase Reporter ◽  
Enzyme Linked Immunosorbent Assay ◽  
Interacting Protein ◽  
Wide Range

Abstract Background Acute lung injury (ALI) is a pulmonary disorder that leads to acute respiration failure and thereby results in a high mortality worldwide. Increasing studies have indicated that toll-like receptor 4 (TLR4) is a promoter in ALI, and we aimed to explore the underlying upstream mechanism of TLR4 in ALI. Methods We used lipopolysaccharide (LPS) to induce an acute inflammatory response in vitro model and a murine mouse model. A wide range of experiments including reverse transcription quantitative polymerase chain reaction, western blot, enzyme linked immunosorbent assay, flow cytometry, hematoxylin–eosin staining, RNA immunoprecipitation, luciferase activity and caspase-3 activity detection assays were conducted to figure out the expression status, specific role and potential upstream mechanism of TLR4 in ALI. Result TLR4 expression was upregulated in ALI mice and LPS-treated primary bronchial/tracheal epithelial cells. Moreover, miR-26a-5p was confirmed to target TLR4 according to results of luciferase reporter assay. In addition, miR-26a-5p overexpression decreased the contents of proinflammatory factors and inhibited cell apoptosis, while upregulation of TLR4 reversed these effects of miR-26a-5p mimics, implying that miR-26a-5p alleviated ALI by regulating TLR4. Afterwards, OPA interacting protein 5 antisense RNA 1 (OIP5-AS1) was identified to bind with miR-26a-5p. Functionally, OIP5-AS1 upregulation promoted the inflammation and miR-26a-5p overexpression counteracted the influence of OIP5-AS1 upregulation on cell inflammatory response and apoptosis. Conclusion OIP5-AS1 promotes ALI by regulating the miR-26a-5p/TLR4 axis in ALI mice and LPS-treated cells, which indicates a promising insight into diagnostics and therapeutics in ALI.

O-GlcNAcase inhibitor has protective effects in intracerebral hemorrhage by suppressing the inflammatory response

Neuroreport ◽  
2021 ◽  
Vol 32 (17) ◽  
pp. 1349-1356
Author(s):  
Yating He ◽  
Haijie Liu ◽  
Ye liu ◽  
Xiaowen Li ◽  
Mengmeng Fan ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Intracerebral Hemorrhage ◽  
Protective Effects

Eupatilin attenuates the inflammatory response induced by intracerebral hemorrhage through the TLR4/MyD88 pathway

2019 ◽  
Vol 76 ◽  
pp. 105837 ◽  
Author(s):  
Xiaowei Fei ◽  
Chen Chen ◽  
Sun Kai ◽  
Xiaojun Fu ◽  
Weitao Man ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Intracerebral Hemorrhage ◽  
Myd88 Pathway

scholarly journals Hypoalbuminemia, systemic inflammatory response syndrome, and functional outcome in intracerebral hemorrhage

2017 ◽  
Vol 41 ◽  
pp. 247-253 ◽  
Author(s):  
Mario Di Napoli ◽  
Réza Behrouz ◽  
Christopher H. Topel ◽  
Vivek Misra ◽  
Fulvio Pomero ◽  
...  
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Intracerebral Hemorrhage ◽  
Functional Outcome ◽  
Systemic Inflammatory Response

scholarly journals The New Inhibitor of Monoamine Oxidase, M30, has a Neuroprotective Effect Against Dexamethasone-Induced Brain Cell Apoptosis

2010 ◽  
Vol 4 ◽  
Author(s):  
Shakevia Johnson ◽  
Shawna Tazik ◽  
Deyin Lu ◽  
Chandra Johnson ◽  
Moussa B. H. Youdim ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Cell Apoptosis ◽  
Neuroprotective Effect ◽  
Brain Cell
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