Val8-GLP-1 remodels synaptic activity and intracellular calcium homeostasis impaired by amyloid β peptide in rats

2013 ◽  
Vol 91 (4) ◽  
pp. 568-577 ◽  
Author(s):  
Xiao-Hui Wang ◽  
Wei Yang ◽  
Christian Hölscher ◽  
Zhao-Jun Wang ◽  
Hong-Yan Cai ◽  
...  
Keyword(s):  
Intracellular Calcium ◽  
Calcium Homeostasis ◽  
Amyloid Β ◽  
Synaptic Activity ◽  
Amyloid Β Peptide ◽  
Intracellular Calcium Homeostasis

Icariin Inhibits the Increased Inward Calcium Currents Induced by Amyloid-β25-35 Peptide in CA1 Pyramidal Neurons of Neonatal Rat Hippocampal Slice

2010 ◽  
Vol 38 (01) ◽  
pp. 113-125 ◽  
Author(s):  
Li Li ◽  
Hao-Jan Tsai ◽  
Lin Li ◽  
Xue-Mei Wang
Keyword(s):  
Intracellular Calcium ◽  
Calcium Homeostasis ◽  
Pyramidal Neurons ◽  
Neuronal Damage ◽  
Neuroprotective Effect ◽  
Amyloid Β ◽  
Calcium Currents ◽  
Neonatal Rat ◽  
Amyloid Β Peptide ◽  
Hippocampal Pyramidal Neurons

Overload of intracellular calcium caused by amyloid-β peptide has been implicated in the pathogenesis of neuronal damage in Alzheimer's disease. Voltage-gated calcium channels (VGCCs) provide one of the major sources of Ca2+ entry into cells. Here, we investigated whether icariin had effect on the changes of calcium currents induced by Aβ25-35 in hippocampal pyramidal neurons. Using whole-cell patch-clamp, we showed that Aβ25-35 enhanced the inward Ba2+ and Ca2+ currents. The currents were partially inhibited by Ni2+ and completely suppressed by Cd2+ , indicating that Aβ25-35 disrupts intracellular calcium homeostasis via the modulation of both L- and T-type channels. Furthermore, icariin nearly complete suppressed the abnormal inward calcium currents induced by Aβ25-35 in a dose-dependant manner. Our findings suggest that the potential neuroprotective effect of icariin on Aβ25-35-induced neurotoxicity via the balance intracelluar calcium homeostasis.

scholarly journals Scn1bdeletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts

2014 ◽  
Vol 593 (6) ◽  
pp. 1389-1407 ◽  
Author(s):  
Xianming Lin ◽  
Heather O'Malley ◽  
Chunling Chen ◽  
David Auerbach ◽  
Monique Foster ◽  
...  
Keyword(s):  
Intracellular Calcium ◽  
Calcium Homeostasis ◽  
Sodium Current ◽  
Intracellular Calcium Homeostasis

Alterations of Intracellular Calcium Homeostasis and Myocardial Energetics in Acute Adriamycin-Induced Heart Failure

1991 ◽  
Vol 18 (3) ◽  
pp. 437-444 ◽  
Author(s):  
Hideo Kusuoka ◽  
Shiho Futaki ◽  
Yukihiro Koretsune ◽  
Akira Kitabatake ◽  
Hiroyuki Suga ◽  
...  
Keyword(s):  
Heart Failure ◽  
Intracellular Calcium ◽  
Calcium Homeostasis ◽  
Intracellular Calcium Homeostasis ◽  
Myocardial Energetics

scholarly journals Protein kinase CK2 impact on intracellular calcium homeostasis in prostate cancer

2020 ◽  
Vol 470 (1-2) ◽  
pp. 131-143
Author(s):  
Muhammad Afzal ◽  
Betsy T. Kren ◽  
A. Khaliq Naveed ◽  
Janeen H. Trembley ◽  
Khalil Ahmed
Keyword(s):  
Prostate Cancer ◽  
Protein Kinase ◽  
Intracellular Calcium ◽  
Calcium Homeostasis ◽  
Protein Kinase Ck2 ◽  
Intracellular Calcium Homeostasis ◽  
Kinase Ck2

scholarly journals Disturbed intracellular calcium homeostasis in neural tube defects in diabetic embryopathy

2019 ◽  
Vol 514 (3) ◽  
pp. 960-966
Author(s):  
Zhiyong Zhao ◽  
Lixue Cao ◽  
Erick Hernández-Ochoa ◽  
Martin F. Schneider ◽  
E. Albert Reece
Keyword(s):  
Intracellular Calcium ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Calcium Homeostasis ◽  
Diabetic Embryopathy ◽  
Intracellular Calcium Homeostasis
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