scholarly journals Cartilage oligomeric matrix protein promotes prostate cancer progression by enhancing invasion and disrupting intracellular calcium homeostasis

Oncotarget ◽  
2017 ◽  
Vol 8 (58) ◽  
pp. 98298-98311 ◽  
Author(s):  
Emelie Englund ◽  
Giacomo Canesin ◽  
Konstantinos S. Papadakos ◽  
Neelanjan Vishnu ◽  
Emma Persson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Intracellular Calcium ◽  
Cancer Progression ◽  
Calcium Homeostasis ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Prostate Cancer Progression ◽  
Intracellular Calcium Homeostasis

scholarly journals Protein kinase CK2 impact on intracellular calcium homeostasis in prostate cancer

2020 ◽  
Vol 470 (1-2) ◽  
pp. 131-143
Author(s):  
Muhammad Afzal ◽  
Betsy T. Kren ◽  
A. Khaliq Naveed ◽  
Janeen H. Trembley ◽  
Khalil Ahmed
Keyword(s):  
Prostate Cancer ◽  
Protein Kinase ◽  
Intracellular Calcium ◽  
Calcium Homeostasis ◽  
Protein Kinase Ck2 ◽  
Intracellular Calcium Homeostasis ◽  
Kinase Ck2

scholarly journals MINDIN Exerts Protumorigenic Actions on Primary Prostate Tumors via Downregulation of the Scaffold Protein NHERF-1

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 436
Author(s):  
Luis Álvarez-Carrión ◽  
Irene Gutiérrez-Rojas ◽  
María Rosario Rodríguez-Ramos ◽  
Juan A. Ardura ◽  
Verónica Alonso
Keyword(s):  
Prostate Cancer ◽  
Mouse Model ◽  
Cancer Progression ◽  
Matrix Protein ◽  
Scaffold Protein ◽  
Human Prostate ◽  
Prostate Cancer Progression ◽  
Prostate Tumors ◽  
Tumor Cell Migration ◽  
Mouse Prostate

Advanced prostate cancer preferential metastasis to bone is associated with osteomimicry. MINDIN is a secreted matrix protein upregulated in prostate tumors that overexpresses bone-related genes during prostate cancer progression. Na+/H+ exchanger regulatory factor (NHERF-1) is a scaffold protein that has been involved both in tumor regulation and osteogenesis. We hypothesize that NHERF-1 modulation is a mechanism used by MINDIN to promote prostate cancer progression. We analyzed the expression of NHERF-1 and MINDIN in human prostate samples and in a premetastatic prostate cancer mouse model, based on the implantation of prostate adenocarcinoma TRAMP-C1 (transgenic adenocarcinoma of the mouse prostate) cells in immunocompetent C57BL/6 mice. The relationship between NHERF-1 and MINDIN and their effects on cell proliferation, migration, survival and osteomimicry were evaluated. Upregulation of MINDIN and downregulation of NHERF-1 expression were observed both in human prostate cancer samples and in the TRAMP-C1 model. MINDIN silencing restored NHERF-1 expression to control levels in the mouse model. Stimulation with MINDIN reduced NHERF-1 expression and triggered its mobilization from the plasma membrane to the cytoplasm in TRAMP-C1 cells. MINDIN-dependent downregulation of NHERF-1 promoted tumor cell migration and proliferation without affecting osteomimicry and adhesion. We propose that MINDIN downregulates NHERF-1 expression leading to promotion of processes involved in prostate cancer progression.

463: Telomerase Inhibition Prevents Androgen Independent Osseous Prostate Cancer Progression

2005 ◽  
Vol 173 (4S) ◽  
pp. 126-127
Author(s):  
Yingming Li ◽  
Melissa Thompson ◽  
Zhu Chen ◽  
Bahaa S. Malaeb ◽  
David Corey ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Telomerase Inhibition ◽  
Androgen Independent

479: Prostate-Specific Membrane Antigen (PSMA) Expression as a Predictor of Prostate Cancer Progression

2006 ◽  
Vol 175 (4S) ◽  
pp. 155-156
Author(s):  
Matthias D. Hofer ◽  
Sven Perner ◽  
Haojie Li ◽  
Rainer Kuefer ◽  
Richard E. Hautmann ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Prostate Specific Membrane Antigen ◽  
Prostate Cancer Progression ◽  
Specific Membrane ◽  
Psma Expression

Androgen pathway regulating microRNAs in prostate cancer progression and therapy

2016 ◽  
Author(s):  
Foteini Kalofonou ◽  
Claire Fletcher ◽  
Jonathan Waxman ◽  
Charlotte Bevan
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Prostate Cancer Progression
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