A dibenzoylmethane derivative protects against hydrogen peroxide-induced cell death and inhibits lipopolysaccharide-induced nitric oxide production in cultured rat astrocytes

2011 ◽  
Vol 89 (6) ◽  
pp. 955-965 ◽  
Author(s):  
K. Takano ◽  
K. Sugita ◽  
M. Moriyama ◽  
K. Hashida ◽  
S. Hibino ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Hydrogen Peroxide ◽  
Cell Death ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Rat Astrocytes

Nitric Oxide Production Correlates with Cell Death of Fibroblasts Treated by Bacillus pumilus Ribonuclease

2017 ◽  
Vol 8 (1) ◽  
pp. 319-322
Author(s):  
Pavel Zelenikhin ◽  
Andreas Koschinski ◽  
Olga Ilinskaya
Keyword(s):  
Nitric Oxide ◽  
Cell Death ◽  
Bacillus Pumilus ◽  
Nitric Oxide Production ◽  
Oxide Production

Antioxidant and Anti-atherogenic Activities of Olive Oil Phenolics

2005 ◽  
Vol 75 (1) ◽  
pp. 61-70 ◽  
Author(s):  
Rufus Turner ◽  
Nicolas Etienne ◽  
Maria Garcia Alonso ◽  
Sonia de Pascual-Teresa ◽  
Anne Marie Minihane ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Hydrogen Peroxide ◽  
Cell Culture ◽  
Cell Adhesion ◽  
Platelet Aggregation ◽  
Olive Oil ◽  
Adhesion Molecule ◽  
Nitric Oxide Production ◽  
Cytotoxic Effects ◽  
Oxide Production

The aim of the current study was to investigate the antioxidant and cellular activity of the olive oil phenolics oleuropein, tyrosol, hydroxytyrosol, and homovanillic alcohol (which is also a major metabolite of hydroxytyrosol). Well-characterized chemical and biochemical assays were used to assess the antioxidant potential of the compounds. Further experiments investigated their influence in cell culture on cytotoxic effects of hydrogen peroxide and oxidized low-density lipoprotein (LDL), nitric oxide production by activated macrophages, and secretion of chemoattractant and cell adhesion molecules by the endothelium. Inhibitory influences on in vitro platelet aggregation were also measured. The antioxidant assays indicated that homovanillic alcohol was a significantly more potent antioxidant than the other phenolics, both in chemical assays and in prolonging the lag phase of LDL oxidation. Cell culture experiments suggested that the olive oil phenolics induce a significant reduction in the secretion of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 (and a trend towards a reduced secretion of monocyte chemoattractant protein-1), and protect against cytotoxic effects of hydrogen peroxide and oxidized LDL. However, no influence on nitric oxide production or platelet aggregation was evident. The data show that olive oil phenolics have biochemical and cellular actions, which, if also apparent in vivo, could exert cardioprotective effects.

Mitochondrial-Driven Ubiquinone Enhances Extracellular Calcium-Dependent Nitric Oxide Production and Reduces Glycochenodeoxycholic Acid-Induced Cell Death in Hepatocytes

2009 ◽  
Vol 22 (12) ◽  
pp. 1984-1991 ◽  
Author(s):  
Sandra González-Rubio ◽  
Ana B. Hidalgo ◽  
Gustavo Ferrín ◽  
Rosario I. Bello ◽  
Raul González ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cell Death ◽  
Extracellular Calcium ◽  
Nitric Oxide Production ◽  
Calcium Dependent ◽  
Oxide Production
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