Up-regulation of oligodendrocyte precursor cell αV integrin and its extracellular ligands during central nervous system remyelination

2009 ◽  
Vol 87 (15) ◽  
pp. 3447-3455 ◽  
Author(s):  
Chao Zhao ◽  
Stephen P.J. Fancy ◽  
Robin J.M. Franklin ◽  
Charles ffrench-Constant
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Precursor Cell ◽  
Oligodendrocyte Precursor Cell ◽  
Oligodendrocyte Precursor

scholarly journals Tapping into the glial reservoir: cells committed to remaining uncommitted

2010 ◽  
Vol 188 (3) ◽  
pp. 305-312 ◽  
Author(s):  
S.Y. Christin Chong ◽  
Jonah R. Chan
Keyword(s):  
Central Nervous System ◽  
Molecular Mechanisms ◽  
Therapeutic Potential ◽  
Precursor Cell ◽  
Oligodendrocyte Precursor Cell ◽  
Spatiotemporal Regulation ◽  
Proliferation And Differentiation ◽  
The Central Nervous System ◽  
Oligodendrocyte Precursor ◽  
Widespread Interest

The development and maturation of the oligodendrocyte requires a series of highly orchestrated events that coordinate the proliferation and differentiation of the oligodendrocyte precursor cell (OPC) as well as the spatiotemporal regulation of myelination. In recent years, widespread interest has been devoted to the therapeutic potential of adult OPCs scattered throughout the central nervous system (CNS). In this review, we highlight molecular mechanisms controlling OPC differentiation during development and the implication of these mechanisms on adult OPCs for remyelination. Cell-autonomous regulators of differentiation and the heterogeneous microenvironment of the developing and the adult CNS may provide coordinated inhibitory cues that ultimately maintain a reservoir of uncommitted glia.

Ginkgolide B promotes oligodendrocyte precursor cell differentiation and survival via Akt/CREB/bcl-2 signaling pathway after white matter lesion

2021 ◽  
pp. 153537022198995
Author(s):  
Jian Huang ◽  
Jun Yang ◽  
Xingju Zou ◽  
Shilun Zuo ◽  
Jing Wang ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Lesion ◽  
Neuroprotective Effect ◽  
Precursor Cell ◽  
Cerebral Hypoperfusion ◽  
Ginkgolide B ◽  
Oligodendrocyte Precursor Cell ◽  
Learning Abilities ◽  
Phosphorylated Akt ◽  
Oligodendrocyte Precursor

White matter lesion (WML) is caused by chronic cerebral hypoperfusion, which are usually associated with cognitive impairment. Evidence from recent studies has shown that ginkgolide B has a neuroprotective effect that could be beneficial for the treatment of ischemia; however, it is not clear whether ginkgolide B has a protective effect on WML. Our data show that ginkgolide B can promote the differentiation of oligodendrocyte precursor cell (OPC) into oligodendrocytes and promote oligodendrocyte survival following a WML. Ginkgolide B (5, 10, 20 mg/kg) or saline is administered intraperitoneally every day after WML. After 4 weeks, the data of Morris water maze suggested that rats’ memory and learning abilities were impaired, and the administration of ginkgolide B enhanced behavioral achievement. Also, treatment with ginkgolide B significantly attenuated this loss of myelin. Our result suggests that ginkgolide B promotes the differentiation of OPC into oligodendrocytes. We also found that ginkgolide B ameliorates oligodendrocytes apoptosis. Furthermore, ginkgolide B enhanced the expression of phosphorylated Akt and CREB. In conclusion, our data firstly show that ginkgolide B promotes oligodendrocyte genesis and oligodendrocyte myelin following a WML, possibly involving the Akt and CREB pathways.

scholarly journals Inhibition of phosphodiesterase‐4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination

2013 ◽  
Vol 5 (12) ◽  
pp. 1918-1934 ◽  
Author(s):  
Yasir A. Syed ◽  
Alexandra Baer ◽  
Matthias P. Hofer ◽  
Ginez A. González ◽  
Jon Rundle ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Precursor Cell ◽  
Oligodendrocyte Precursor Cell ◽  
Phosphodiesterase 4 ◽  
Oligodendrocyte Precursor
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