scholarly journals Inhibition of phosphodiesterase‐4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination

2013 ◽  
Vol 5 (12) ◽  
pp. 1918-1934 ◽  
Author(s):  
Yasir A. Syed ◽  
Alexandra Baer ◽  
Matthias P. Hofer ◽  
Ginez A. González ◽  
Jon Rundle ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Precursor Cell ◽  
Oligodendrocyte Precursor Cell ◽  
Phosphodiesterase 4 ◽  
Oligodendrocyte Precursor

scholarly journals Shikimic Acid Promotes Oligodendrocyte Precursor Cell Differentiation and Accelerates Remyelination in Mice

2019 ◽  
Vol 35 (3) ◽  
pp. 434-446 ◽  
Author(s):  
Fengfeng Lu ◽  
Dou Yin ◽  
Yingyan Pu ◽  
Weili Liu ◽  
Zhenghao Li ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Shikimic Acid ◽  
Precursor Cell ◽  
Oligodendrocyte Precursor Cell ◽  
Oligodendrocyte Precursor

scholarly journals Signaling via Immunoglobulin Fc Receptors Induces Oligodendrocyte Precursor Cell Differentiation

2003 ◽  
Vol 4 (6) ◽  
pp. 841-852 ◽  
Author(s):  
Jin Nakahara ◽  
Kyoko Tan-Takeuchi ◽  
Chika Seiwa ◽  
Mari Gotoh ◽  
Tomonori Kaifu ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Fc Receptors ◽  
Precursor Cell ◽  
Oligodendrocyte Precursor Cell ◽  
Oligodendrocyte Precursor

scholarly journals Inactivation of LCN2/EGR1 Promotes Oligodendrocyte Progenitor Cell Differentiation and Remyelination after White Matter Injury

2020 ◽  
Author(s):  
Qiang Li ◽  
Xufang Ru ◽  
Yang Yang ◽  
Hengli Zhao ◽  
Jie Qu ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
White Matter ◽  
Growth Response ◽  
Early Growth ◽  
Precursor Cell ◽  
White Matter Injury ◽  
Lipocalin 2 ◽  
Oligodendrocyte Precursor Cell ◽  
Early Growth Response ◽  
Oligodendrocyte Precursor

AbstractThe insufficient remyelination due to the impaired oligodendrocyte precursor cell differentiation and maturation is highly associated with irreversible white matter injury and neurological deficits. Consequently, inhibitory components and microenvironment for remyelination might serve as potential therapeutic targets for treating white matter injury after acute central nervous system injury and neurodegeneration diseases. Lipocalin-2 was recently reported to corelate with white matter in both atypical, acute white matter injured disease subarachnoid hemorrhage and typical, chronic white matter injured disease multiple sclerosis. To elucidate the role and underlying mechanism of Lipocalin-2 in oligodendrocyte precursor cell differentiation and remyelination, we used genetic inhibition and a constitutive conditional knockout model with subarachnoid hemorrhage or multiple sclerosis. We found that the genetic inhibition of the increase in Lipocalin-2 promoted oligodendrocyte precursor cell differentiation, remyelination, and functional recovery after subarachnoid hemorrhage or multiple sclerosis. Unexpectedly, the inhibition of Lipocalin-2 did not reduce glial activation and inflammation. Lipocalin-2 was shown to activate Early Growth Response Protein 1 in oligodendrocyte precursor cells, which is partly regulated by its receptor SLC22A17. In the conditional knockout of Early Growth Response Protein 1 in oligodendrocyte precursor cells, we discovered enhanced oligodendrocyte precursor cell differentiation in developing and injured white matter; consistently, the specific inactivation of Early Growth Response Protein 1 promoted remyelination and neurological recovery after subarachnoid hemorrhage or multiple sclerosis. Thus, we propose that following white matter injury in humans, the increase in Lipocalin-2 activates Early Growth Response Protein 1 and consequently impair oligodendrocyte precursor cell differentiation and myelin repair. Our results suggest that therapies specifically inactivating Lipocalin-2/ Early Growth Response Protein 1 signal in oligodendroglial lineage cells could represent a novel strategy to enhance differentiation and remyelination in white matter injury patients.

SOX17 transcription factor negatively regulates oligodendrocyte precursor cell differentiation

Glia ◽  
2018 ◽  
Vol 66 (10) ◽  
pp. 2221-2232 ◽  
Author(s):  
Melissa Fauveau ◽  
Baptiste Wilmet ◽  
Cyrille Deboux ◽  
Karelle Benardais ◽  
Corinne Bachelin ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Cell Differentiation ◽  
Precursor Cell ◽  
Oligodendrocyte Precursor Cell ◽  
Oligodendrocyte Precursor

scholarly journals Front Cover: Investigation of Oligodendrocyte Precursor Cell Differentiation by Quantitative Proteomics

PROTEOMICS ◽  
2019 ◽  
Vol 19 (14) ◽  
pp. 1970121
Author(s):  
Carmen Schoor ◽  
Nahal Brocke-Ahmadinejad ◽  
Volkmar Gieselmann ◽  
Dominic Winter
Keyword(s):  
Cell Differentiation ◽  
Quantitative Proteomics ◽  
Precursor Cell ◽  
Oligodendrocyte Precursor Cell ◽  
Front Cover ◽  
Oligodendrocyte Precursor

scholarly journals MiR-219a-5p Enriched Extracellular Vesicles Induce OPC Differentiation and EAE Improvement More Efficiently Than Liposomes and Polymeric Nanoparticles

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 186 ◽  
Author(s):  
Iñaki Osorio-Querejeta ◽  
Susana Carregal-Romero ◽  
Ana Ayerdi-Izquierdo ◽  
Imre Mäger ◽  
Leslie A. Nash ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cell Differentiation ◽  
Extracellular Vesicles ◽  
Polymeric Nanoparticles ◽  
Plga Nanoparticles ◽  
Precursor Cell ◽  
Oligodendrocyte Precursor Cell ◽  
Promising Tool ◽  
Oligodendrocyte Precursor ◽  
Multiple Sclerosis Patients

Remyelination is a key aspect in multiple sclerosis pathology and a special effort is being made to promote it. However, there is still no available treatment to regenerate myelin and several strategies are being scrutinized. Myelination is naturally performed by oligodendrocytes and microRNAs have been postulated as a promising tool to induce oligodendrocyte precursor cell differentiation and therefore remyelination. Herein, DSPC liposomes and PLGA nanoparticles were studied for miR-219a-5p encapsulation, release and remyelination promotion. In parallel, they were compared with biologically engineered extracellular vesicles overexpressing miR-219a-5p. Interestingly, extracellular vesicles showed the highest oligodendrocyte precursor cell differentiation levels and were more effective than liposomes and polymeric nanoparticles crossing the blood–brain barrier. Finally, extracellular vesicles were able to improve EAE animal model clinical evolution. Our results indicate that the use of extracellular vesicles as miR-219a-5p delivery system can be a feasible and promising strategy to induce remyelination in multiple sclerosis patients.

TIP30 inhibits oligodendrocyte precursor cell differentiation via cytoplasmic sequestration of Olig1

Glia ◽  
2014 ◽  
Vol 63 (4) ◽  
pp. 684-698 ◽  
Author(s):  
Wenjing Yang ◽  
Lin Xiao ◽  
Cui Li ◽  
Xiuyun Liu ◽  
Mingdong Liu ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Precursor Cell ◽  
Oligodendrocyte Precursor Cell ◽  
Oligodendrocyte Precursor
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