scholarly journals Parkin reverses intracellular β-amyloid accumulation and its negative effects on proteasome function

2009 ◽  
Vol 88 (1) ◽  
pp. 167-178 ◽  
Author(s):  
Kenneth M. Rosen ◽  
Charbel E.-H. Moussa ◽  
Han-Kyu Lee ◽  
Pravir Kumar ◽  
Tohru Kitada ◽  
...  
Keyword(s):  
Negative Effects ◽  
Amyloid Accumulation ◽  
Β Amyloid

scholarly journals Concurrent Treatment with Taxifolin and Cilostazol on the Lowering of β-Amyloid Accumulation and Neurotoxicity via the Suppression of P-JAK2/P-STAT3/NF-κB/BACE1 Signaling Pathways

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0168286 ◽  
Author(s):  
So Youn Park ◽  
Hae Young Kim ◽  
Hee Jeong Park ◽  
Hwa Kyoung Shin ◽  
Ki Whan Hong ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Concurrent Treatment ◽  
Amyloid Accumulation ◽  
Β Amyloid

Visual-discrimination learning ability and β-amyloid accumulation in the dog

1998 ◽  
Vol 19 (5) ◽  
pp. 415-425 ◽  
Author(s):  
E. Head ◽  
H. Callahan ◽  
B.A. Muggenburg ◽  
C.W. Cotman ◽  
N.W. Milgram
Keyword(s):  
Discrimination Learning ◽  
Visual Discrimination ◽  
Learning Ability ◽  
Visual Discrimination Learning ◽  
Amyloid Accumulation ◽  
Β Amyloid

scholarly journals Pre-therapeutic Microglia Activation and Sex Determine Therapy Effects of Chronic Immunomodulation

2021 ◽  
Author(s):  
Gloria Biechele ◽  
Tanja Blume ◽  
Maximilian Deussing ◽  
Benedikt Zott ◽  
Yuan Shi ◽  
...  
Keyword(s):  
Spatial Learning ◽  
Microglial Activation ◽  
Translocator Protein ◽  
Learning Performance ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Activated Microglia ◽  
Ppar Γ ◽  
Amyloid Accumulation ◽  
Β Amyloid

Modulation of the innate immune system is emerging as a promising therapeutic strategy against Alzheimer's disease (AD). However, determinants of a beneficial therapeutic effect are ill-understood. Thus, we investigated the potential of 18 kDa translocator protein positron-emission-tomography (TSPO-PET) for assessment of microglial activation in mouse brain before and during chronic immunomodulation. Serial TSPO-PET was performed during five months of chronic microglia modulation by stimulation of peroxisome proliferator-activated receptor (PPAR)-γ with pioglitazone in two different mouse models of AD (PS2APP, AppNL-G-F). Using mixed statistical models on longitudinal TSPO-PET data, we tested for effects of therapy and sex on treatment response. We tested correlations of baseline with longitudinal measures of TSPO-PET, and correlations between PET results with spatial learning performance and β-amyloid accumulation of individual mice. Immunohistochemistry was used to determine the molecular source of the TSPO-PET signal. Pioglitazone-treated female PS2APP and AppNL-G-F mice showed attenuation of the longitudinal increases in TSPO-PET signal when compared to vehicle controls, whereas treated male AppNL-G-F mice showed the opposite effect. Baseline TSPO-PET strongly predicted changes in microglial activation in treated mice (R=-0.874, p<0.0001) but not in vehicle controls (R=-0.356, p=0.081). Reduced TSPO-PET signal upon treatment was associated with better spatial learning and higher fibrillar β-amyloid accumulation. Immunohistochemistry confirmed activated microglia to be the source of the TSPO-PET signal (R=0.952, p<0.0001). TSPO-PET represents a sensitive biomarker for monitoring of immunomodulation and closely reflects activated microglia. Pre-therapeutic assessment of baseline microglial activation and sex are strong predictors of individual immunomodulation effects and could serve for responder stratification.

scholarly journals Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

Neuron ◽  
2001 ◽  
Vol 30 (3) ◽  
pp. 665-676 ◽  
Author(s):  
Robert A Cherny ◽  
Craig S Atwood ◽  
Michel E Xilinas ◽  
Danielle N Gray ◽  
Walton D Jones ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transgenic Mice ◽  
Amyloid Accumulation ◽  
Zinc Chelator ◽  
Copper Zinc ◽  
Β Amyloid

scholarly journals GRK5 Deficiency Accelerates β-Amyloid Accumulation in Tg2576 Mice via Impaired Cholinergic Activity

2010 ◽  
Vol 285 (53) ◽  
pp. 41541-41548 ◽  
Author(s):  
Shaowu Cheng ◽  
Longxuan Li ◽  
Shuangteng He ◽  
Jun Liu ◽  
Yuning Sun ◽  
...  
Keyword(s):  
Cholinergic Activity ◽  
Amyloid Accumulation ◽  
Β Amyloid ◽  
Tg2576 Mice

Rate of β-amyloid accumulation varies with baseline amyloid burden: Implications for anti-amyloid drug trials

2018 ◽  
Vol 14 (11) ◽  
pp. 1387-1396 ◽  
Author(s):  
Tengfei Guo ◽  
Juergen Dukart ◽  
Matthias Brendel ◽  
Axel Rominger ◽  
Timo Grimmer ◽  
...  
Keyword(s):  
Drug Trials ◽  
Amyloid Burden ◽  
Amyloid Accumulation ◽  
Β Amyloid

scholarly journals TFEB Probably Involved in Midazolam-Disturbed Lysosomal Homeostasis and Its Induced β-Amyloid Accumulation

2019 ◽  
Vol 13 ◽  
Author(s):  
Dan Cheng ◽  
Qilian Tan ◽  
Qianyun Zhu ◽  
Jiqian Zhang ◽  
Xiaoyu Han ◽  
...  
Keyword(s):  
Amyloid Accumulation ◽  
Β Amyloid

scholarly journals MiR-144 promotes β-amyloid accumulation-induced cognitive impairments by targeting ADAM10 following traumatic brain injury

Oncotarget ◽  
2017 ◽  
Vol 8 (35) ◽  
pp. 59181-59203 ◽  
Author(s):  
Liqian Sun ◽  
Manman Zhao ◽  
Jingbo Zhang ◽  
Aihua Liu ◽  
Wenjun Ji ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Impairments ◽  
Amyloid Accumulation ◽  
Β Amyloid
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