scholarly journals Cholinergic synaptic signaling mechanisms underlying behavioral teratogenicity: Effects of nicotine, chlorpyrifos, and heroin converge on protein kinase C translocation in the intermedial part of the hyperstriatum ventrale and on imprinting behavior in an avian model

2004 ◽  
Vol 78 (4) ◽  
pp. 499-507 ◽  
Author(s):  
Michal Izrael ◽  
Eddy A. Van der Zee ◽  
Theodore A. Slotkin ◽  
Joseph Yanai
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Synaptic Signaling ◽  
Kinase C ◽  
Signaling Mechanisms ◽  
Hyperstriatum Ventrale

Calcium/protein kinase C signaling mechanisms in shear-induced mechanical responses of red blood cells

2021 ◽  
Vol 135 ◽  
pp. 104124
Author(s):  
Elif Ugurel ◽  
Zeynep Busra Kisakurek ◽  
Yasemin Aksu ◽  
Evrim Goksel ◽  
Neslihan Cilek ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Mechanical Responses ◽  
Kinase C ◽  
Signaling Mechanisms

scholarly journals Cytokine-mediated protein kinase C activation is a signal for lineage determination in bipotential granulocyte macrophage colony-forming cells.

1994 ◽  
Vol 125 (3) ◽  
pp. 651-659 ◽  
Author(s):  
A D Whetton ◽  
C M Heyworth ◽  
S E Nicholls ◽  
C A Evans ◽  
J M Lord ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Soft Agar ◽  
Kinase C ◽  
Signaling Mechanisms ◽  
Macrophage Colony Stimulating Factor ◽  
Pkc Alpha ◽  
Macrophage Colony ◽  
Stimulating Factor ◽  
Protein Kinase C Activation

Granulocyte macrophage colony-forming cells (GM-CFC) have the potential to develop into either macrophages and/or neutrophils. With a highly enriched population of these cells we have found that although GM-CFC are equally responsive to macrophage colony stimulating factor (M-CSF) and stem cell factor (SCF) in terms of DNA synthesis, M-CSF stimulated the development of colonies containing macrophages in soft gel assays, while SCF promoted neutrophilic colony formation. When SCF and M-CSF were combined, mainly macrophage development was stimulated both in soft agar colony-forming assays and liquid cultures. An analysis of some potential signaling mechanisms associated with cytokine-mediated developmental decisions in GM-CFC revealed that M-CSF, but not SCF, was able to chronically stimulate phosphatidylcholine breakdown and diacylglycerol production, indicating that protein kinase C (PKC) may be involved in the action of M-CSF. Furthermore, M-CSF, but not SCF, can increase the levels of PKC alpha (PKC alpha) expression and stimulate the translocation of PKC alpha to the nucleus. When the PKC inhibitor, calphostin C, was added to GM-CFC cultured in M-CSF then predominantly neutrophils were produced, conversely PKC activators added with SCF stimulated macrophage development. The data indicate a role for PKC in M-CSF-stimulated macrophage development from GM-CFC.

Sign in / Sign up

Export Citation Format

Share Document