Insulin-like growth factor 1 prevents neuronal cell death induced by corticosterone through activation of the PI3k/Akt pathway

2004 ◽  
Vol 76 (1) ◽  
pp. 98-103 ◽  
Author(s):  
Atsumi Nitta ◽  
Wen-Hua Zheng ◽  
R�mi Quirion
Keyword(s):  
Cell Death ◽  
Growth Factor ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Akt Pathway ◽  
Insulin Like Growth Factor

scholarly journals Insulin-like growth factor 1 prevents neuronal cell death and paraplegia in the rabbit model of spinal cord ischemia

2001 ◽  
Vol 122 (1) ◽  
pp. 136-143 ◽  
Author(s):  
Yoshihisa Nakao ◽  
Hajime Otani ◽  
Tadashi Yamamura ◽  
Reiji Hattori ◽  
Motohiko Osako ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cell Death ◽  
Growth Factor ◽  
Spinal Cord Ischemia ◽  
Neuronal Cell Death ◽  
Rabbit Model ◽  
Neuronal Cell ◽  
Insulin Like Growth Factor

scholarly journals Pro-Nerve Growth Factor Induces Activation of RhoA Kinase and Neuronal Cell Death

2019 ◽  
Vol 9 (8) ◽  
pp. 204 ◽  
Author(s):  
Marina Sycheva ◽  
Jake Sustarich ◽  
Yuxian Zhang ◽  
Vaithinathan Selvaraju ◽  
Thangiah Geetha ◽  
...  
Keyword(s):  
Cell Death ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Kinase Activity ◽  
Kinase Inhibitor ◽  
Neuronal Cell Death ◽  
Rho Kinase ◽  
Neuronal Cell ◽  
Nerve Growth ◽  
Rhoa Kinase

We have previously shown that the expression of pro-nerve growth factor (proNGF) was significantly increased, nerve growth factor (NGF) level was decreased, and the expression of p75NTR was enhanced in Alzheimer’s disease (AD) hippocampal samples. NGF regulates cell survival and differentiation by binding TrkA and p75NTR receptors. ProNGF is the precursor form of NGF, binds to p75NTR, and induces cell apoptosis. The objective of this study is to determine whether the increased p75NTR expression in AD is due to the accumulation of proNGF and Rho kinase activation. PC12 cells were stimulated with either proNGF or NGF. Pull-down assay was carried out to determine the RhoA kinase activity. We found the expression of p75NTR was enhanced by proNGF compared to NGF. The proNGF stimulation also increased the RhoA kinase activity leading to apoptosis. The expression of active RhoA kinase was found to be increased in human AD hippocampus compared to control. The addition of RhoA kinase inhibitor Y27632 not only blocked the RhoA kinase activity but also reduced the expression of p75NTR receptor and inhibited the activation of JNK and MAPK induced by proNGF. This suggests that overexpression of proNGF in AD enhances p75NTR expression and activation of RhoA, leading to neuronal cell death.

scholarly journals Artemisinin Prevents Glutamate-Induced Neuronal Cell Death Via Akt Pathway Activation

2018 ◽  
Vol 12 ◽  
Author(s):  
Shao-Peng Lin ◽  
Wenjun Li ◽  
Ali Winters ◽  
Ran Liu ◽  
Shao-Hua Yang
Keyword(s):  
Cell Death ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Akt Pathway ◽  
Pathway Activation

Nerve growth factor and neuronal cell death

1990 ◽  
Vol 4 (1-2) ◽  
pp. 57-91 ◽  
Author(s):  
J. Regino Perez-Polo ◽  
Perry J. Foreman ◽  
George R. Jackson ◽  
Din-e Shan ◽  
Giulio Taglialatela ◽  
...  
Keyword(s):  
Cell Death ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Nerve Growth
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