Study of expression of myelin basic proteins (MBPs) in developing rat brain using a novel antibody reacting with four major isoforms of MBP

2002 ◽  
Vol 68 (1) ◽  
pp. 19-28 ◽  
Author(s):  
Kyoichi Akiyama ◽  
Sachiyo Ichinose ◽  
Akira Omori ◽  
Yoko Sakurai ◽  
Hiroaki Asou
Keyword(s):  
Rat Brain ◽  
Basic Proteins ◽  
Developing Rat

scholarly journals Turnover of myelin and other structural proteins in the developing rat brain

1974 ◽  
Vol 142 (3) ◽  
pp. 499-507 ◽  
Author(s):  
M. I. Sabri ◽  
A. H. Bone ◽  
A. N. Davison
Keyword(s):  
Rat Brain ◽  
Slow Component ◽  
Proteolipid Protein ◽  
Myelin Proteins ◽  
Turnover Rates ◽  
Basic Proteins ◽  
Glucose Injection ◽  
Total Brain ◽  
The Difference ◽  
Developing Rat

1. Protein metabolism of myelin and other subcellular components from developing rat brain was studied for periods from 5h to 210 days after intraperitoneal injection of [3H]lysine and [14C]glucose. 2. Half-lives for total brain proteins (t0.5) were 27 days after [3H]lysine and 4 days after [14C]glucose injection. 3. Factors accounting for the difference in the turnover rates obtained with different precursors, and the problem of reutilization of the label were investigated. 4. The catabolism of purified myelin proteins was studied and the half-lives of individual myelin proteins were calculated. 5. Myelin basic proteins turned over at two different rates. Half-life of the fast component of myelin basic proteins was 19–22 days and the slow component exhibited a high degree of metabolic stability. 6. Proteolipid protein underwent slow turnover. High-molecular-weight Wolfgram (1966) proteins underwent (relatively) fast metabolism (t0.5 of 17–22 days).

Regulation of tubulin by triiodothyronine in hypothyroid rat brain

1985 ◽  
Vol 5 (8) ◽  
pp. 643-648 ◽  
Author(s):  
Anjana Mazumder ◽  
Kamal Das ◽  
Pranab K. Sarkar
Keyword(s):  
Protein Synthesis ◽  
Rat Brain ◽  
Brain Maturation ◽  
Normal Brain ◽  
Neonatal Brain ◽  
Organ Cultures ◽  
Postnatal Brain ◽  
Enhanced Sensitivity ◽  
Brain Exposure ◽  
Developing Rat

The effect of T3 (triiodothyronine) on the induction of tubulin in hypothyroid developing rat brain has been examined using organ cultures of brains from late fetal, neonatal and postnatalrats. The neonatal brain displayed maximum sensitivity to T3. Hypothyroidism resulted in a 26% decline in the level of tubulin in the neonatal brain as opposed to a 5–15% decline in the fetal or postnatal brain. Exposure of the hypothyroi d neonatal brain to T3 for 2 h in culture led to a 61% rise in the level of tubulin in contrast to a 41% increase seen in the case of normal brain. Total protein synthesis was not significantly affected. The preferential decline of tubulin in the neonatal hypothyroid brain, its enhanced sensitivity to T3 compared to normal brain, and the coincidence of the period of sensitivity to that of brain maturation indicate that the regulation of the level of tubulin by T3 in the developing brain is a natural ontogenic phenomenon.

scholarly journals Effect of Hypoxic-Ischemic Injury on Serine Palmitoyltransferase Activity in the Developing Rat Brain

Pathobiology ◽  
2008 ◽  
Vol 75 (6) ◽  
pp. 330-334 ◽  
Author(s):  
Masaki Daigo ◽  
Yasuhiro Arai ◽  
Kyoichi Oshida ◽  
Yohei Kitamura ◽  
Masaharu Hayashi ◽  
...  
Keyword(s):  
Rat Brain ◽  
Ischemic Injury ◽  
Serine Palmitoyltransferase ◽  
Developing Rat ◽  
Hypoxic Ischemic Injury
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