Distribution of +874T/A IFN‐γ and ‐509C/T TGF‐β1 Single Nucleotide Polymorphisms in Human Immunodeficiency Virus‐infected Thais

2022 ◽  
Author(s):  
Chareeporn Akekawatchai ◽  
Chada Phuegsilp ◽  
Khaimuk Changsri ◽  
Thanawan Soimanee ◽  
Warisara Sretapunya
Keyword(s):  
Human Immunodeficiency Virus ◽  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Immunodeficiency Virus ◽  
Ifn Γ ◽  
Tgf Β1

scholarly journals Effects of Single Nucleotide Polymorphisms 869 T/C in the Exon 1 Locus of Transforming Growth Factor-β1 Gene on Susceptibility and Airflow Restriction of Chronic Obstructive Pulmonary Disease

2021 ◽  
Author(s):  
Jie Liu ◽  
Wenjing Zhu
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Single Nucleotide Polymorphisms ◽  
Healthy Volunteers ◽  
Chronic Obstructive ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Obstructive Pulmonary Disease ◽  
Genotype Frequencies ◽  
Copd Patients ◽  
Tgf Β1

Abstract Background: Chronic obstructive pulmonary disease (COPD) is the most common chronic respiratory disease which is expected to become the third leading cause of death worldwide in 2030. Series of susceptibility genes and single nucleotide polymorphism (SNPs) play an important role in the occurrence and development of COPD.Methods: In our study, 98 COPD patients and 90 healthy volunteers were enrolled. The +869 SNP (SNP, Single Nucleotide Polymorphisms) of TGF-β1 was detected in 98 COPD patients and 90 healthy volunteers by PCR-DNA sequencing. The effects of different genotypes of +869 locus on the susceptibility of COPD, pulmonary function and airflow limitation of COPD patients were analyzed.Results: Allele C of +869 locus was associated with the susceptibility of COPD (OR:1.913, 95% CI: 1.251-2.926). The predicted value of FEV1% (FEV1, Forced Expiratory Volume in One Second) in patients with CC of +869 locus was significantly lower than that in patients with TT (P < 0.05). The genotype frequencies of CC, CT and TT were 6.5%, 58.7% and 34.8% in Mild-to-Moderate airflow restriction patients. In severe airflow restriction patients, the genotype frequencies were CC 23.1%, CT 57.7% and TT 19.2%. The distribution of CC genotype in severe airflow restriction COPD patients was significantly higher than that in Mild-to-Moderate airflow restriction COPD patients (P = 0.037). Moreover, the frequency of C allele was significantly higher in patients with severe airflow restriction than that patients with Mild-to-Moderate airflow restriction (P = 0.024).Conclusions: The SNP of +869 T/C in TGF-β1 is closely related to the susceptibility of COPD and the airflow restriction of COPD patients.

scholarly journals TGF-β1 and IL-10 single nucleotide polymorphisms as risk factors for oral cancer in Taiwanese

2015 ◽  
Vol 31 (3) ◽  
pp. 123-129 ◽  
Author(s):  
Han-Jen Hsu ◽  
Yi-Hsin Yang ◽  
Tien-Yu Shieh ◽  
Chung-Ho Chen ◽  
Yu-Hsun Kao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Oral Cancer ◽  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Tgf Β1
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