scholarly journals Evaluation of Rapid Antibody Test and Chest Computed Tomography Results of COVID‐19 Patients: A Retrospective Study

2021 ◽  
Author(s):  
Ali Ozturk ◽  
Taylan Bozok ◽  
Tugce Simsek Bozok
Keyword(s):  
Computed Tomography ◽  
Retrospective Study ◽  
Antibody Test ◽  
Chest Computed Tomography ◽  
Rapid Antibody

scholarly journals Evaluation of rapid antibody test and chest computed tomography results of COVID-19 patients: A retrospective study

2021 ◽  
Author(s):  
Ali Ozturk ◽  
Taylan Bozok ◽  
Tugce Simsek Bozok
Keyword(s):  
Computed Tomography ◽  
Ct Scan ◽  
Antibody Test ◽  
Chest Ct ◽  
Rt Pcr ◽  
Serum Samples ◽  
Chest Computed Tomography ◽  
Ct Data ◽  
Chest Ct Scan ◽  
Rapid Antibody

AbstractBackgroundThe coronavirus disease 2019 (COVID-19) continues to spread around the world. Therefore, rapid, simpler, and more accurate diagnostic tests are urgently needed to diagnose the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. The purpose of this study was to evaluate the SARS-CoV-2 IgM/ IgG rapid antibody test results in symptomatic patients with COVID-19 and their chest computed tomography (CT) data.MethodsA total of 320 patients admitted to our hospital for different durations due to COVID-19 were included in the study. Serum samples were obtained within 0 to 7 days from COVID-19 patients confirmed by RT-PCR and chest CT scan. According to the SARS-CoV-2 RT-PCR results, the patients included in the study were divided into two groups: PCR positive group (n=46), and PCR negative group (n=274).ResultsOf the 320 COVID-19 serum samples, IgM, IgG, and IgM/IgG were detected in 9.4%, 3.1%, and 17.8% within one week respectively. IgG/IgM antibodies were not detected in 69.7% of the patients. In the study, it was determined that 249 (77.8%) of 320 patients had positive chest CT scans. Four (5.6%) of 100 patients with negative chest CT scan had IgM positive and 2 (2.8%) had both IgM/ IgG positive. IgM was detected in 23 (9.2%), IgG in 1 (0.4%) and IgM/IgG in 35 (14%) of chest CT scan positive patients. The rate of CT findings in patients with antibody positivity (n=97) was found to be significantly higher than those with antibody negativity.ConclusionsThe results of the present study show the accurate and equivalent performance of serological antibody assays and chest CT in detecting SARS-CoV-2 0 to 7 days from the onset of COVID19 symptoms. When the RT-PCR is not available, we believe that the combination of immunochromatographic test and chest CT scan can increase diagnostic sensitivity for COVID-19.

scholarly journals Correction of the authors' list and affiliations to “Specificity of chest computed tomography in COVID-19-associated pneumonia: a retrospective study“

2021 ◽  
Vol 49 ◽  
Keyword(s):  
Computed Tomography ◽  
Retrospective Study ◽  
Clinical Medicine ◽  
Final Version ◽  
Chest Computed Tomography ◽  
Corrected Version

Herewith we would like to inform our readers that the final version of the article doi: 10.18786/2072-0505-2021- 49-001, published online on 02.03.2021, was replaced with a corrected version on 15.03.2021. The corrected version, according to the authors request, includes the following changes: the author list and the affiliations, authors' contributions, acknowledgements sections. The article should be cited as “Korb TA, Gavrilov PV, Chernina VYu, Blokhin IA, Aleshina OO, Mokienko OA, Morozov SP, Gombolevskiy VA. Specificity of chest computed tomography in COVID-19-associated pneumonia: a retrospective study. Almanac of Clinical Medicine. 2021;49. doi: 10.18786/2072-0505-2021-49-001.

scholarly journals Accuracy of noncontrast chest computed tomography in COVID-19 infection: An observational and retrospective study

2020 ◽  
Vol 17 (3) ◽  
pp. 282
Author(s):  
ZaidHadi Hammoodi ◽  
HasanFalah Al-Khafaji ◽  
ZeidHamid Al-Murib ◽  
HussainKetab Al-Esawy ◽  
AliSalih Baiee ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Retrospective Study ◽  
Chest Computed Tomography

scholarly journals Clinical evaluation of an immunochromatographic IgM/IgG antibody assay and chest computed tomography for the diagnosis of COVID-19

2020 ◽  
Author(s):  
Kazuo Imai ◽  
Sakiko Tabata ◽  
Mayu Ikeda ◽  
Sakiko Noguchi ◽  
Yutaro Kitagawa ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Clinical Performance ◽  
Diagnostic Testing ◽  
Antibody Test ◽  
Chest Ct ◽  
Antibody Assay ◽  
Igg Antibody ◽  
Chest Computed Tomography ◽  
Asymptomatic Patients ◽  
Novel Coronavirus

AbstractBackgroundWe evaluated the clinical performance of an immunochromatographic (IC) IgM/IgG antibody assay for severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) and chest computed tomography (CT) for the diagnosis of Coronavirus disease 2019 (COVID-19).MethodsWe examined 139 serum specimens collected from 112 patients with COVID-19 and 48 serum specimens collected from 48 non-COVID-19 patients. The presence of IgM/IgG antibody for SARS-CoV2 was determined using the One Step Novel Coronavirus (COVID-19) IgM/IgG Antibody Test. Chest CT was performed in COVID-19 patients on admission.FindingsOf the139 COVID-19 serum specimens, IgM was detected in 27.8%, 48.0%, and 95.8% of the specimens collected within 1 week, 1–2 weeks, and >2 weeks after symptom onset and IgG was detected in 3.3%, 8.0%, and 62.5%, respectively. Among the 48 non-COVID-19 serum specimens, 1 generated a false-positive result for IgM. Thirty-eight of the 112 COVID-19 patients were asymptomatic, of whom 15 were positive for IgM, and 74 were symptomatic, of whom 22 were positive for IgM and 7 were positive for IgG. The diagnostic sensitivity of CT scan alone and in combination with the IC assay was 57.9 % (22/38) and 68.4% (26/38) for the asymptomatic patients and 74.3% (55/74) and 82.4% (61/74) for the symptomatic patients, respectively.ConclusionThe IC assay had low sensitivity during the early phase of infection, and thus IC assay alone is not recommended for initial diagnostic testing for COVID-19. If RT-qPCR is not available, the combination of chest CT and IC assay may be useful for diagnosing COVID-19.

Choosing Wisely: Computed Tomography in the Diagnosis of Adolescents With Intrathoracic Tuberculosis

2020 ◽  
Author(s):  
Spenta Kakalia ◽  
Aparna Chakravarty ◽  
David Manson ◽  
Ray Lam ◽  
Valerie Waters ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Mycobacterium Tuberculosis ◽  
Retrospective Study ◽  
Chest Ct ◽  
Choosing Wisely ◽  
Sputum Smear ◽  
Smear Microscopy ◽  
Molecular Testing ◽  
Sputum Smear Microscopy ◽  
Chest Computed Tomography

Abstract In a retrospective study of adolescents with intrathoracic tuberculosis (TB), 26 out of the 81 (32%) patients had undergone chest computed tomography (CT). Chest CT was considered unnecessary in 7 (27%), necessary in 7 (27%), and possibly/probably helpful in 12 (46%). Promptly obtaining specimens for sputum smear microscopy, molecular testing, as well as culture for Mycobacterium tuberculosis could avoid several unnecessary CTs.

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