Etiology, seasonality, and clinical characteristics of respiratory viruses in children with respiratory tract infections in Eastern India (Bhubaneswar, Odisha)

2016 ◽  
Vol 89 (3) ◽  
pp. 553-558 ◽  
Author(s):  
Swagatika Panda ◽  
Nirmal Kumar Mohakud ◽  
Mrutyunjay Suar ◽  
Subrat Kumar
Keyword(s):  
Respiratory Tract ◽  
Clinical Characteristics ◽  
Respiratory Tract Infections ◽  
Respiratory Viruses ◽  
Eastern India ◽  
Tract Infections

scholarly journals Extracellular amoebal-vesicles: potential transmission vehicles for respiratory viruses

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Rafik Dey ◽  
Melanie A. Folkins ◽  
Nicholas J. Ashbolt
Keyword(s):  
Respiratory Syncytial Virus ◽  
Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Respiratory Viruses ◽  
Environmental Persistence ◽  
Viral Dissemination ◽  
Acute Respiratory Tract Infections ◽  
High Concentrations ◽  
Syncytial Virus ◽  
Tract Infections

AbstractHuman respiratory syncytial virus (RSV) is a major cause of acute respiratory tract infections in children and immunocompromised adults worldwide. Here we report that amoebae-release respirable-sized vesicles containing high concentrations of infectious RSV that persisted for the duration of the experiment. Given the ubiquity of amoebae in moist environments, our results suggest that extracellular amoebal-vesicles could contribute to the environmental persistence of respiratory viruses, including potential resistance to disinfection processes and thereby offering novel pathways for viral dissemination and transmission.

scholarly journals Associations Between IFI44L Gene Variants and Rates of Respiratory Tract Infections During Early Childhood

2020 ◽  
Vol 223 (1) ◽  
pp. 157-165
Author(s):  
Johanna Lempainen ◽  
Laura S Korhonen ◽  
Katri Kantojärvi ◽  
Santtu Heinonen ◽  
Laura Toivonen ◽  
...  
Keyword(s):  
Early Childhood ◽  
Respiratory Tract ◽  
Otitis Media ◽  
Respiratory Tract Infections ◽  
Acute Otitis Media ◽  
Respiratory Viruses ◽  
Birth Cohort Study ◽  
Type I ◽  
Gene Variants ◽  
Tract Infections

Abstract Background Genetic heterogeneity in type I interferon (IFN)–related gene IFI44L may account for variable susceptibility to respiratory tract infections (RTIs) in children. Methods In 2 prospective, population-based birth cohorts, the STEPS Study and the FinnBrain Birth Cohort Study, IFI44L genotypes for rs273259 and rs1333969 were determined in relation to the development of RTIs until 1 or 2 years of age, respectively. At age 3 months, whole-blood transcriptional profiles were analyzed and nasal samples were tested for respiratory viruses in a subset of children. Results In the STEPS Study (n = 1135), IFI44L minor/minor gene variants were associated with lower rates of acute otitis media episodes (adjusted incidence rate ratio, 0.77 [95% confidence interval, .61–.96] for rs273259 and 0.74 [.55–.99] for rs1333969) and courses of antibiotics for RTIs (0.76 [.62–.95] and 0.73 [.56–.97], respectively. In the FinnBrain cohort (n = 971), IFI44L variants were associated with lower rates of RTIs and courses of antibiotics for RTIs. In respiratory virus–positive 3-month-old children, IFI44L gene variants were associated with decreased expression levels of IFI44L and several other IFN-related genes. Conclusions Variant forms of IFI44L gene were protective against early-childhood RTIs or acute otitis media, and they attenuated IFN pathway activation by respiratory viruses.

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