scholarly journals Longitudinal study on oral shedding of herpes simplex virus 1 and varicella-zoster virus in individuals infected with HIV

2013 ◽  
Vol 85 (9) ◽  
pp. 1669-1677 ◽  
Author(s):  
Monique van Velzen ◽  
Werner J.D. Ouwendijk ◽  
Stacy Selke ◽  
Suzan D. Pas ◽  
Freek B. van Loenen ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Longitudinal Study ◽  
Herpes Simplex ◽  
Varicella Zoster Virus ◽  
Herpes Simplex Virus 1 ◽  
Varicella Zoster ◽  
Simplex Virus

scholarly journals Frequency and Abundance of Alphaherpesvirus DNA in Human Thoracic Sympathetic Ganglia

2014 ◽  
Vol 88 (14) ◽  
pp. 8189-8192 ◽  
Author(s):  
Maria A. Nagel ◽  
April Rempel ◽  
Jonathon Huntington ◽  
Forrest Kim ◽  
Alexander Choe ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Varicella Zoster Virus ◽  
Sympathetic Ganglia ◽  
Herpes Simplex Virus 1 ◽  
Varicella Zoster ◽  
Target Organs ◽  
Simplex Virus ◽  
Visceral Disease ◽  
Hsv 1

Alphaherpesvirus reactivation from thoracic sympathetic ganglia (TSG) and transaxonal spread to target organs cause human visceral disease. Yet alphaherpesvirus latency in TSG has not been well characterized. In this study, quantitative PCR detected varicella-zoster virus (VZV), herpes simplex virus 1 (HSV-1), and HSV-2 DNA in 117 fresh TSG obtained postmortem from 15 subjects. VZV DNA was found in 76 (65%) ganglia from all subjects, HSV-1 DNA was found in 5 (4%) ganglia from 3 subjects, and no HSV-2 was found.

Herpes Simplex Virus-1 and Varicella-Zoster Virus Latency in Ganglia

2003 ◽  
Vol 9 (2) ◽  
pp. 194-204 ◽  
Author(s):  
Bradley M Mitchell ◽  
David C Bloom ◽  
Randall J Cohrs ◽  
Donald H Gilden ◽  
Peter GE Kennedy
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Varicella Zoster Virus ◽  
Herpes Simplex Virus 1 ◽  
Varicella Zoster ◽  
Virus Latency ◽  
Simplex Virus

scholarly journals Differences in the Likelihood of Acyclovir Resistance-Associated Mutations in the Thymidine Kinase Genes of Herpes Simplex Virus 1 and Varicella-Zoster Virus

2019 ◽  
Vol 63 (5) ◽  
Author(s):  
Hikaru Fujii ◽  
Shizuko Harada ◽  
Tomoki Yoshikawa ◽  
Souichi Yamada ◽  
Natsumi Omura ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Varicella Zoster Virus ◽  
Thymidine Kinase ◽  
Low Frequency ◽  
Herpes Simplex Virus 1 ◽  
Varicella Zoster ◽  
Simplex Virus ◽  
Hsv 1

ABSTRACTAcyclovir (ACV) resistance-associated mutations in two recombinant herpes simplex virus 1 (HSV-1) clones were compared. Recombinant HSV-1 lacking its thymidine kinase (TK) and expressing varicella-zoster virus (VZV) TK ectopically had no mutations in the VZV TK gene. In contrast, recombinant HSV-1 expressing HSV-1 TK ectopically harbored mutations in the HSV-1 TK gene. These results suggest that the relatively low frequency of ACV-resistant VZV is a consequence of the characteristics of the TK gene.

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