Characterization of oseltamivir-resistant influenza A(H1N1)pdm09 viruses in Taiwan in 2009-2011

2012 ◽  
Vol 85 (3) ◽  
pp. 379-387 ◽  
Author(s):  
Ji-Rong Yang ◽  
Yuan-Pin Huang ◽  
Feng-Yee Chang ◽  
Li-Ching Hsu ◽  
Hsiang-Yi Huang ◽  
...  
Keyword(s):  
Influenza A ◽  
Influenza A H1n1

scholarly journals Epidemiological Characterization of Influenza A(H1N1)pdm09 Cases from 2009 to 2010 in Baguio City, the Philippines

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e79916 ◽  
Author(s):  
Rochelle R. Pamaran ◽  
Taro Kamigaki ◽  
Teresita T. Hewe ◽  
Korrine Madeleine C. Flores ◽  
Edelwisa S. Mercado ◽  
...  
Keyword(s):  
Influenza A ◽  
The Philippines ◽  
Influenza A H1n1 ◽  
Epidemiological Characterization

scholarly journals Characterization of neuraminidase inhibitor-resistant influenza A(H1N1)pdm09 viruses isolated in four seasons during pandemic and post-pandemic periods in Japan

2013 ◽  
Vol 7 (6) ◽  
pp. 1390-1399 ◽  
Author(s):  
Emi Takashita ◽  
Seiichiro Fujisaki ◽  
Noriko Kishida ◽  
Hong Xu ◽  
Masaki Imai ◽  
...  
Keyword(s):  
Influenza A ◽  
Neuraminidase Inhibitor ◽  
Four Seasons ◽  
Influenza A H1n1

scholarly journals In silico analysis and molecular characterization of Influenza A (H1N1) pdm09 virus circulating and causing major outbreaks in central India, 2009-2019

2020 ◽  
Author(s):  
Arshi Siddiqui ◽  
Rashmi Chowdhary ◽  
Harjeet Singh Maan ◽  
Sudhir Kumar Goel ◽  
Nidhi Tripathi ◽  
...  
Keyword(s):  
Amino Acid ◽  
Vaccine Efficacy ◽  
Influenza A ◽  
In Silico Analysis ◽  
Central India ◽  
Gene Sequences ◽  
Ha Gene ◽  
Influenza A H1n1 ◽  
Silico Analysis

Background and Objectives: Influenza A/H1N1pdm09 causes respiratory illness and remains a concern for public health. Since its first emergence in 2009, the virus has been continuously circulating in the form of its genetic variants. Influenza A/ H1N1pdm09 surveillance is essential for uncovering emerging variants of epidemiologic and vaccine efficacy. The present study attempts in silico analysis and molecular characterization of Influenza A (H1N1) pdm09 virus circulating and causing major outbreaks in central India during 2009-2019. Materials and Methods: We have investigated the antigenic drift analysis of 96 isolates’ hemagglutinin (HA) gene sequences (59 central Indian and 37 local Indian and 28 global reference HA gene sequences) of Influenza A/H1N1pdm09 viruses from 2009 to 2019. The study includes mutational (Multiple sequence Alignment), phylogenetic (Maximum Likelihood Method), and statistical analysis (Covariance and correlation) of HA sequences submitted in NCBI, IRD and GISAID from central India. Results: Phylogenetic analysis indicated maximum clustering of central Indian HA gene sequences in genogroup 6B. Analysis of amino acid sequence alignment revealed changes in receptor binding site (RBS). The frequency of S220T amino acid substitution was found to be high followed by S202T, K300E A273T, K180Q. The Karl Pearson correlation coefficient (r) and covariance between the number of mutations and the death toll was found +0.246 and +100.3 respectively. Conclusion: The study identifies the continuous genetic variations in the HA gene sequences of circulating Influenza A/ H1N1pdm09 in central India from the year 2009 to 2019. Further suggesting importance of monitoring the gradual evolution of the virus with regards to an increase in virulence, pathogenicity and vaccine efficacy timely.

Sequence-based identification and characterization of nosocomial influenza A(H1N1)pdm09 virus infections

2012 ◽  
Vol 82 (3) ◽  
pp. 187-193 ◽  
Author(s):  
M. Jonges ◽  
J. Rahamat-Langendoen ◽  
A. Meijer ◽  
H.G. Niesters ◽  
M. Koopmans
Keyword(s):  
Influenza A ◽  
Virus Infections ◽  
Pdm09 Virus ◽  
Influenza A H1n1 ◽  
Identification And Characterization

scholarly journals Whole genome characterization of human influenza A(H1N1)pdm09 viruses isolated from Kenya during the 2009 pandemic

2016 ◽  
Vol 40 ◽  
pp. 98-103 ◽  
Author(s):  
George Gachara ◽  
Samuel Symekher ◽  
Michael Otieno ◽  
Japheth Magana ◽  
Benjamin Opot ◽  
...  
Keyword(s):  
Influenza A ◽  
Whole Genome ◽  
Human Influenza ◽  
Genome Characterization ◽  
Influenza A H1n1

scholarly journals Molecular characterization of influenza A(H1N1)pdm09 in Cameroon during the 2014-2016 influenza seasons

PLoS ONE ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. e0210119 ◽  
Author(s):  
Chavely Gwladys Monamele ◽  
Hermann Landry Munshili Njifon ◽  
Marie-Astrid Vernet ◽  
Mohamadou Ripa Njankouo ◽  
Sebastien Kenmoe ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Influenza A ◽  
Influenza A H1n1

Characterization of pandemic influenza A (H1N1) virus hemagglutinin specific polyclonal antibodies for biosensor applications

2013 ◽  
Vol 86 (3) ◽  
pp. 363-371 ◽  
Author(s):  
T.N. Athmaram ◽  
Shweta Saraswat ◽  
Bhavna Sikarwar ◽  
Shailendra Kumar Verma ◽  
Anil K. Singh ◽  
...  
Keyword(s):  
Pandemic Influenza ◽  
Influenza A ◽  
H1n1 Virus ◽  
Polyclonal Antibodies ◽  
Influenza A H1n1 ◽  
Biosensor Applications

scholarly journals Characterization of 2009 Pandemic Influenza A (H1N1) Virus Specimens with a Positive Hemagglutinin 1 Signal in the Luminex xTAG Respiratory Viral Panel Assay

2011 ◽  
Vol 49 (4) ◽  
pp. 1657-1658 ◽  
Author(s):  
C. B. McCloskey ◽  
C. S. Kraft ◽  
J. M. Ingersoll ◽  
C. E. Hill ◽  
E. M. Burd ◽  
...  
Keyword(s):  
Pandemic Influenza ◽  
Influenza A ◽  
H1n1 Virus ◽  
Influenza A H1n1

scholarly journals Characterization of influenza A(H1N1)pdm09 viruses in Germany in season 2019-2020 – co-circulation of an antigenic drift variant

2021 ◽  
Author(s):  
Marianne Wedde ◽  
Djin-Ye Oh ◽  
Silke Buda ◽  
Andrea Thürmer ◽  
Sandra Kaiser ◽  
...  
Keyword(s):  
Influenza A ◽  
Influenza Season ◽  
Vaccine Virus ◽  
Influenza Viruses ◽  
Antigenic Drift ◽  
Neuraminidase Inhibitors ◽  
Pdm09 Virus ◽  
Time Period ◽  
Influenza A H1n1

Background Influenza A(H1N1)pdm09 virus entered the human population in 2009 and evolved within this population for more than ten years. Despite genetic evolution no remarkable changes in the antigenic reactive pattern of these viruses were observed so far. Methods Primary respiratory samples of the German influenza virological sentinel were investigated by qPCR. Influenza virus-positive samples were characterized genetically and antigenetically. Results In December 2019, a antigenic drift variant characterized by an N156K substitution in the hemagglutinin of influenza A(H1N1)pdm09 virus emerged in Germany, which exhibited a reactivity to ferret antiserum that was an average 6 log2 lower than the vaccine virus A/Brisbane/02/2018 and the other A(H1N1)pdm09 viruses circulating in the influenza season 2019-2020. These viruses accounted for 20% of all A(H1N1)pdm09 viruses characterized in the German influenza sentinel. Patients infected with these viruses had a shorter median time period of medical consultation after onset of symptoms and were more frequently treated with neuraminidase inhibitors in comparison to patients infected with other A(H1N1)pdm09 viruses. Conclusions This parallel circulation of two antigenic variants of A(H1N1)pdm09 viruses which differ remarkably in their antigenic reactive pattern contributes to a greater variability in circulating influenza viruses and challenges vaccination.

Sign in / Sign up

Export Citation Format

Share Document