scholarly journals Mutations in the major hydrophilic region (MHR) of Hepatitis B virus genotype C in North China

2012 ◽  
Vol 84 (12) ◽  
pp. 1901-1906 ◽  
Author(s):  
Ying Shi ◽  
Feili Wei ◽  
Dongmei Hu ◽  
Qing Li ◽  
Davey Smith ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
North China ◽  
Virus Genotype ◽  
Major Hydrophilic Region ◽  
B Virus ◽  
Hydrophilic Region ◽  
Genotype C

The prevalence of mutations in the major hydrophilic region of the surface antigen of hepatitis B virus varies with subgenotype

2015 ◽  
Vol 143 (16) ◽  
pp. 3572-3582 ◽  
Author(s):  
X. Y. WANG ◽  
T. J. HARRISON ◽  
X. HE ◽  
Q. Y. CHEN ◽  
G. J. LI ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Cluster Sampling ◽  
Resistance Mutations ◽  
Major Hydrophilic Region ◽  
B Virus ◽  
Hydrophilic Region ◽  
Genotype C ◽  
Asymptomatic Individuals

SUMMARYMutations in the major hydrophilic region (MHR) of the surface antigen of hepatitis B virus (HBV) may result in vaccine escape, failure of immunotherapy and antiviral resistance. These mutants may be transmitted and constitute a public health threat. We aimed to determine the prevalence of MHR mutations of HBV in areas of high endemicity in Guangxi, China. HBV surface gene was analysed from 278 HBsAg-positive asymptomatic individuals recruited from Guangxi using cluster sampling. Three genotypes, B, C and I, were identified. The overall prevalence of MHR mutations is 17·6%. The prevalence of MHR mutations in genotype B (15·1%) is not significantly different from that in genotype C (16·4%). However, the prevalence in subgenotype C5 (31·1%) is significantly higher than in subgenotype C2 (13·0%) (χ2= 6·997,P< 0·05). The prevalence of escape mutations and overlapping polymerase substitutions in subgenotype C5 is significantly higher than in subgenotypes B2 and C2. In total, 7·9% of MHR mutants are escape mutations and 72·1% of MHR mutations produced amino-acid changes in the overlapping polymerase, including resistance mutations to entecavir. Our results suggest that the prevalence of MHR mutations varies with subgenotype. The prevalence of escape mutations and polymerase mutations may be associated with subgenotype.

Predominance of hepatitis B virus genotype C among Karens, the ‘old settlers’ of Andaman and Nicobar Islands, India

2007 ◽  
Vol 152 (6) ◽  
pp. 1223-1228 ◽  
Author(s):  
S. Datta ◽  
P. K. Chandra ◽  
A. Banerjee ◽  
R. Chakravarty ◽  
K. M. Murhekar ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Andaman And Nicobar Islands ◽  
Virus Genotype ◽  
B Virus ◽  
Genotype C ◽  
Nicobar Islands

N-glycosylation mutations within hepatitis B virus surface major hydrophilic region contribute mostly to immune escape

2014 ◽  
Vol 60 (3) ◽  
pp. 515-522 ◽  
Author(s):  
De-Min Yu ◽  
Xin-Hua Li ◽  
Vannary Mom ◽  
Zhong-Hua Lu ◽  
Xiang-Wei Liao ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Immune Escape ◽  
Major Hydrophilic Region ◽  
Virus Surface ◽  
B Virus ◽  
Hydrophilic Region

Prevalence of S gene mutations within the major hydrophilic region of hepatitis B virus in patients in Dongguan, southern China

2017 ◽  
Vol 162 (10) ◽  
pp. 2949-2957 ◽  
Author(s):  
Siping Li ◽  
Mingyu Xie ◽  
Wenrui Li ◽  
Qi Peng ◽  
Baimao Zhong ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Southern China ◽  
Gene Mutations ◽  
Major Hydrophilic Region ◽  
S Gene ◽  
B Virus ◽  
Hydrophilic Region

scholarly journals High prevalence of hepatitis B virus genotype C/C1 in the Minangkabau ethnic group in Indonesia

2013 ◽  
Vol 10 (1) ◽  
pp. 27 ◽  
Author(s):  
Marlinang D Siburian ◽  
Andi Utama ◽  
Rama Dhenni ◽  
null Arnelis ◽  
Ismail Fanany ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Ethnic Group ◽  
Virus Genotype ◽  
B Virus ◽  
High Prevalence ◽  
Genotype C

scholarly journals Another novel subgenotype of hepatitis B virus genotype C from papuans of Highland origin

2010 ◽  
Vol 83 (2) ◽  
pp. 225-234 ◽  
Author(s):  
Juniastuti ◽  
Takako Utsumi ◽  
Victor Eka Nugrahaputra ◽  
Mochamad Amin ◽  
Soetjipto ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Genotype ◽  
B Virus ◽  
Genotype C

Hepatitis B virus genotype C encoding resistance mutations that emerge during adefovir dipivoxil therapy: in vitro replication phenotype

2012 ◽  
Vol 7 (2) ◽  
pp. 443-450 ◽  
Author(s):  
Wenpeng Li ◽  
Nadia Warner ◽  
Vitina Sozzi ◽  
Lilly Yuen ◽  
Danni Colledge ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Adefovir Dipivoxil ◽  
Resistance Mutations ◽  
Virus Genotype ◽  
In Vitro Replication ◽  
B Virus ◽  
Genotype C
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