Viral load and epidemiological profile of patients infected by pandemic influenza a (H1N1) 2009 and seasonal influenza a virus in Southern Brazil

2012 ◽  
Vol 84 (3) ◽  
pp. 371-379 ◽  
Author(s):  
Ana Beatriz Gorini da Veiga ◽  
Nélson Alexandre Kretzmann ◽  
Laura Trevizan Corrêa ◽  
Alessandra Mari Goshiyama ◽  
Tatiana Baccin ◽  
...  
Keyword(s):  
Viral Load ◽  
Influenza A Virus ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Seasonal Influenza ◽  
Southern Brazil ◽  
Influenza A H1n1 ◽  
Epidemiological Profile

scholarly journals Clinico-epidemiological profile, pandemic influenza a h1n1/2009 and seasonal influenza, august 2009-march 2013, Himachal Pradesh, India

2016 ◽  
Vol 41 (1) ◽  
pp. 69 ◽  
Author(s):  
VinodKumar Mehta ◽  
Pooja Sharma ◽  
RameshChand Guleria ◽  
SuniteA Ganju ◽  
Digvijay Singh ◽  
...  
Keyword(s):  
Pandemic Influenza ◽  
Influenza A ◽  
Seasonal Influenza ◽  
Himachal Pradesh ◽  
Influenza A H1n1 ◽  
Epidemiological Profile

scholarly journals Development of Two Types of Rapid Diagnostic Test Kits To Detect the Hemagglutinin or Nucleoprotein of the Swine-Origin Pandemic Influenza A Virus H1N1

2011 ◽  
Vol 18 (3) ◽  
pp. 494-499 ◽  
Author(s):  
Rika Mizuike ◽  
Tadahiro Sasaki ◽  
Koichi Baba ◽  
Hisahiko Iwamoto ◽  
Yusuke Shibai ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Seasonal Influenza ◽  
Virus Detection ◽  
Virus H1n1 ◽  
Viral Hemagglutinin ◽  
Detection Assay ◽  
Influenza A H1n1 ◽  
New Type

ABSTRACTSince its emergence in April 2009, pandemic influenza A virus H1N1 (H1N1 pdm), a new type of influenza A virus with a triple-reassortant genome, has spread throughout the world. Initial attempts to diagnose the infection in patients using immunochromatography (IC) relied on test kits developed for seasonal influenza A and B viruses, many of which proved significantly less sensitive to H1N1 pdm. Here, we prepared monoclonal antibodies that react with H1N1 pdm but not seasonal influenza A (H1N1 and H3N2) or B viruses. Using two of these antibodies, one recognizing viral hemagglutinin (HA) and the other recognizing nucleoprotein (NP), we developed kits for the specific detection of H1N1 pdm and tested them using clinical specimens of nasal wash fluid or nasopharyngeal fluid from patients with influenza-like illnesses. The specificities of both IC test kits were very high (93% for the HA kit, 100% for the NP kit). The test sensitivities for detection of H1N1 pdm were 85.5% with the anti-NP antibody, 49.4% with the anti-HA antibody, and 79.5% with a commercially available influenza A virus detection assay. Use of the anti-NP antibody could allow the rapid and accurate diagnosis of H1N1 pdm infections.

scholarly journals Hospitalized Children with 2009 Pandemic Influenza A (H1N1): Comparison to Seasonal Influenza and Risk Factors for Admission to the ICU

PLoS ONE ◽  
2010 ◽  
Vol 5 (12) ◽  
pp. e15173 ◽  
Author(s):  
Dayanand Bagdure ◽  
Donna J. Curtis ◽  
Emily Dobyns ◽  
Mary P. Glodé ◽  
Samuel R. Dominguez
Keyword(s):  
Risk Factors ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Seasonal Influenza ◽  
Hospitalized Children ◽  
Influenza A H1n1

scholarly journals Contemporary Seasonal Influenza A (H1N1) Virus Infection Primes for a More Robust Response To Split Inactivated Pandemic Influenza A (H1N1) Virus Vaccination in Ferrets

2010 ◽  
Vol 17 (12) ◽  
pp. 1998-2006 ◽  
Author(s):  
Ali H. Ellebedy ◽  
Thomas P. Fabrizio ◽  
Ghazi Kayali ◽  
Thomas H. Oguin ◽  
Scott A. Brown ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Seasonal Influenza ◽  
H1n1 Virus ◽  
H1n1 Influenza ◽  
Influenza Viruses ◽  
Inactivated Vaccine ◽  
H1n1 Influenza Virus ◽  
Influenza A H1n1

ABSTRACT Human influenza pandemics occur when influenza viruses to which the population has little or no immunity emerge and acquire the ability to achieve human-to-human transmission. In April 2009, cases of a novel H1N1 influenza virus in children in the southwestern United States were reported. It was retrospectively shown that these cases represented the spread of this virus from an ongoing outbreak in Mexico. The emergence of the pandemic led to a number of national vaccination programs. Surprisingly, early human clinical trial data have shown that a single dose of nonadjuvanted pandemic influenza A (H1N1) 2009 monovalent inactivated vaccine (pMIV) has led to a seroprotective response in a majority of individuals, despite earlier studies showing a lack of cross-reactivity between seasonal and pandemic H1N1 viruses. Here we show that previous exposure to a contemporary seasonal H1N1 influenza virus and to a lesser degree a seasonal influenza virus trivalent inactivated vaccine is able to prime for a higher antibody response after a subsequent dose of pMIV in ferrets. The more protective response was partially dependent on the presence of CD8+ cells. Two doses of pMIV were also able to induce a detectable antibody response that provided protection from subsequent challenge. These data show that previous infection with seasonal H1N1 influenza viruses likely explains the requirement for only a single dose of pMIV in adults and that vaccination campaigns with the current pandemic influenza vaccines should reduce viral burden and disease severity in humans.

scholarly journals Response to 2009 Pandemic Influenza A (H1N1) Vaccine in HIV-Infected Patients and the Influence of Prior Seasonal Influenza Vaccination

PLoS ONE ◽  
2011 ◽  
Vol 6 (1) ◽  
pp. e16496 ◽  
Author(s):  
Darius Soonawala ◽  
Guus F. Rimmelzwaan ◽  
Luc B. S. Gelinck ◽  
Leo G. Visser ◽  
Frank P. Kroon
Keyword(s):  
Influenza Vaccination ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Seasonal Influenza ◽  
H1n1 Vaccine ◽  
Seasonal Influenza Vaccination ◽  
Influenza A H1n1

scholarly journals Convalescent Plasma Treatment Reduced Mortality in Patients With Severe Pandemic Influenza A (H1N1) 2009 Virus Infection

2011 ◽  
Vol 52 (4) ◽  
pp. 447-456 ◽  
Author(s):  
Ivan FN Hung ◽  
Kelvin KW To ◽  
Cheuk-Kwong Lee ◽  
Kar-Lung Lee ◽  
Kenny Chan ◽  
...  
Keyword(s):  
Intensive Care ◽  
Viral Load ◽  
Treatment Group ◽  
Respiratory Tract ◽  
Plasma Treatment ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Control Group ◽  
Severity Scores ◽  
Influenza A H1n1

Background. Experience from treating patients with Spanish influenza and influenza A(H5N1) suggested that convalescent plasma therapy might be beneficial. However, its efficacy in patients with severe pandemic influenza A(H1N1) 2009 virus (H1N1 2009) infection remained unknown. Methods. During the period from 1 September 2009 through 30 June 2010, we conducted a prospective cohort study by recruiting patients aged ≥18 years with severe H1N1 2009 infection requiring intensive care. Patients were offered treatment with convalescent plasma with a neutralizing antibody titer of ≥1:160, harvested by apheresis from patients recovering from H1N1 2009 infection. Clinical outcome was compared with that of patients who declined plasma treatment as the untreated controls. Results. Ninety-three patients with severe H1N1 2009 infection requiring intensive care were recruited. Twenty patients (21.5%) received plasma treatment. The treatment and control groups were matched by age, sex, and disease severity scores. Mortality in the treatment group was significantly lower than in the nontreatment group (20.0% vs 54.8%; P =  .01). Multivariate analysis showed that plasma treatment reduced mortality (odds ratio [OR], .20; 95% confidence interval [CI], .06-.69; P =  .011), whereas complication of acute renal failure was independently associated with death (OR, 3.79; 95% CI, 1.15-12.4; P =  .028). Subgroup analysis of 44 patients with serial respiratory tract viral load and cytokine level demonstrated that plasma treatment was associated with significantly lower day 3, 5, and 7 viral load, compared with the control group (P <  .05). The corresponding temporal levels of interleukin 6, interleukin 10, and tumor necrosis factor α (P <  .05) were also lower in the treatment group. Conclusions. Treatment of severe H1N1 2009 infection with convalescent plasma reduced respiratory tract viral load, serum cytokine response, and mortality.

scholarly journals A Comparison of the Epidemiology and Clinical Presentation of Seasonal Influenza A and 2009 Pandemic Influenza A (H1N1) in Guatemala

PLoS ONE ◽  
2010 ◽  
Vol 5 (12) ◽  
pp. e15826 ◽  
Author(s):  
Kim A. Lindblade ◽  
Wences Arvelo ◽  
Jennifer Gray ◽  
Alejandra Estevez ◽  
Gal Frenkel ◽  
...  
Keyword(s):  
Pandemic Influenza ◽  
Influenza A ◽  
Seasonal Influenza ◽  
Clinical Presentation ◽  
Influenza A H1n1
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