Molecular characterization of BK polyomavirus subtypes in renal transplant recipients in Brazil

2011 ◽  
Vol 83 (8) ◽  
pp. 1401-1405 ◽  
Author(s):  
Ana Carolina Jonard Zalona ◽  
Guilherme Santoro Lopes ◽  
Carlos Guerra Schrago ◽  
Renato Torres Gonçalves ◽  
Mariano Gustavo Zalis ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Molecular Characterization ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Bk Polyomavirus

First report and molecular characterization of hepatitis E virus infection in renal transplant recipients in Brazil

2013 ◽  
Vol 85 (4) ◽  
pp. 615-619 ◽  
Author(s):  
Ana Maria Passos ◽  
Tiago Pires Heringer ◽  
José Osmar Medina-Pestana ◽  
Maria Lucia Gomes Ferraz ◽  
Celso Francisco Hernandes Granato
Keyword(s):  
Renal Transplant ◽  
Virus Infection ◽  
Molecular Characterization ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
First Report

Human BK Polyomavirus Nephropathy (BKVN) In Non- Kidney-Transplant Patients

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S118-S118
Author(s):  
Y Chen Wongworawat ◽  
C Zuppan
Keyword(s):  
Renal Transplant ◽  
Kidney Transplant ◽  
Graft Loss ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Transplant Patients ◽  
Bk Polyomavirus ◽  
Pathologic Features ◽  
Renal Biopsies ◽  
Renal Transplant Patients

Abstract Introduction/Objective Human BK polyomavirus nephropathy (BKVN) occurs in up to 10% of renal transplant recipients, and can result in graft loss. Transplant biopsy is the gold standard to diagnose BKVN, and SV40 immunohistochemical (IHC) staining is helpful in confirming the diagnosis. BKVN is uncommon outside the setting of renal transplantation. To understand more about its occurrence in other contexts, we reviewed our renal biopsies files for cases of BKVN. Methods Our renal biopsy files for the past 20 years were reviewed for all cases with a diagnosis of BKVN or polyoma virus infection, and the clinical characteristics of the affected patients noted. Results Evidence of BKVN was found in 44 renal biopsies, of which 39 (86%) were renal transplant patients. Of the remaining five patients (14%), two had undergone heart transplantation, one lung transplantation, one was undergoing chemotherapy for acute lymphoblastic leukemia, and one patient had active HIV infection. All patients had elevated serum creatinine, and four out of five patients had documented BK viremia. Four of the five biopsies showed typical tubular injury with viral nuclear cytopathic changes (inclusions). In the lung transplant patient, the biopsy showed advanced chronic tubulointerstitial injury without distinct viral inclusions, but SV40 staining confirmed the presence of BK virus antigen. Conclusion The BKVN is distinctly uncommon outside the context of kidney transplantation. In our series, 14% of patients with BKVN were not kidney transplant recipients, but all were immune compromised in some fashion. The pathologic features of BKVN appear similar, regardless of whether the host is a renal transplant recipient or not. Although uncommon, it is important to consider the possibility of BKVN in non-renal transplant patients with persistent or progressive renal dysfunction.

Nucleic Acid Tests for BK Polyomavirus Is Critical in Renal Transplant Recipients

2018 ◽  
Vol 50 (8) ◽  
pp. 2489-2492
Author(s):  
Y.-L. Chang ◽  
Y.-T. Cheng ◽  
T.-C. Chen ◽  
Y.-S. Chien ◽  
W.-C. Lee ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Bk Polyomavirus ◽  
Nucleic Acid Tests

BK polyomavirus genotypes in renal transplant recipients in the United States: A meta‐analysis

2019 ◽  
Vol 12 (4) ◽  
pp. 291-299 ◽  
Author(s):  
Charat Thongprayoon ◽  
Nadeen J. Khoury ◽  
Tarun Bathini ◽  
Narothama Reddy Aeddula ◽  
Boonphiphop Boonpheng ◽  
...  
Keyword(s):  
United States ◽  
Renal Transplant ◽  
Meta Analysis ◽  
The United States ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Bk Polyomavirus

scholarly journals Identification of a genomic subgroup of BK polyomavirus spread in European populations

2006 ◽  
Vol 87 (11) ◽  
pp. 3201-3208 ◽  
Author(s):  
Hiroshi Ikegaya ◽  
Pekka J. Saukko ◽  
Risto Tertti ◽  
Kaj P. Metsärinne ◽  
Michael J. Carr ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Dna Sequences ◽  
Marrow Transplant ◽  
Haematopoietic Stem Cell ◽  
Cell Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Haemorrhagic Cystitis ◽  
North East ◽  
Bk Polyomavirus

BK polyomavirus (BKV) is highly prevalent in the human population, infecting children without obvious symptoms and persisting in the kidney in a latent state. In immunosuppressed patients, BKV is reactivated and excreted in urine. BKV isolates worldwide are classified into four serologically distinct subtypes, I–IV, with subtype I being the most frequently detected. Furthermore, subtype I is subdivided into subgroups based on genomic variations. In this study, the distribution patterns of the subtypes and subgroups of BKV were compared among four patient populations with various immunosuppressive states and of various ethnic backgrounds: (A) Finnish renal-transplant recipients; (B) Irish/English haematopoietic stem-cell transplant recipients with and without haemorrhagic cystitis; (C) Japanese renal-transplant recipients; and (D) Japanese bone-marrow transplant recipients. The typing sequences (287 bp) of BKV in population A were determined in this study; those in populations B–D have been reported previously. These sequences were subjected to phylogenetic and single nucleotide polymorphism analyses. Based on the results of these analyses, the BKV isolates in the four patient populations were classified into subtypes and subgroups. The incidence of subtype IV varied significantly among patient populations. Furthermore, the incidence of subgroup Ib-2 within subtype I was high in populations A and B, whereas that of Ic was high in populations C and D (P<0.01). These results suggest that subgroup Ib-2 is widespread among Europeans, whereas Ic is unique to north-east Asians. Furthermore, a phylogenetic analysis based on complete BKV DNA sequences supported the hypothesis that there is geographical separation of European and Asian BKV strains.

Sign in / Sign up

Export Citation Format

Share Document