BK polyomavirus genotypes in renal transplant recipients in the United States: A meta‐analysis

2019 ◽  
Vol 12 (4) ◽  
pp. 291-299 ◽  
Author(s):  
Charat Thongprayoon ◽  
Nadeen J. Khoury ◽  
Tarun Bathini ◽  
Narothama Reddy Aeddula ◽  
Boonphiphop Boonpheng ◽  
...  
Keyword(s):  
United States ◽  
Renal Transplant ◽  
Meta Analysis ◽  
The United States ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Bk Polyomavirus

scholarly journals Survival Improvement among Patients with End-Stage Renal Disease: Trends over Time for Transplant Recipients and Wait-Listed Patients

2001 ◽  
Vol 12 (6) ◽  
pp. 1293-1296 ◽  
Author(s):  
HERWIG-ULF MEIER-KRIESCHE ◽  
AKINLOLU O. OJO ◽  
FRIEDRICH K. PORT ◽  
JULIE A. ARNDORFER ◽  
DIANE M. CIBRIK ◽  
...  
Keyword(s):  
United States ◽  
Renal Transplant ◽  
Survival Benefit ◽  
The United States ◽  
Mortality Rates ◽  
Waiting List ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Patient Death ◽  
Maintenance Dialysis

Abstract. Both transplant and dialysis outcomes have improved over recent years. In addition, transplantation has been shown to confer a survival benefit over maintenance dialysis. The study presented here addresses the question of whether the survival benefit of transplantation over maintenance dialysis has changed in the most recent eras. This study was based on data collected by the United States Renal Transplant Scientific Registry and the United States Renal Data System. The study sample consisted of 104,000 patients placed on the renal transplant waiting list between 1988 and 1996, of which 73,707 subsequently received renal transplants. The annualized adjusted mortality rates per 1000 patient-years were calculated by calendar year of placement on the renal transplant waiting list and for kidney transplant recipients. The resulting data were plotted, and linear curve fitting was used to estimate the slope of the change of the adjusted mortality rates by year during the period studied, 1988 to 1996. Overall annual adjusted death rates in the wait-listed patients and transplant recipients per 1000 patient-years decreased for both groups throughout the study period. From 1989 to 1996, the relative risk (RR) for patient death had decreased by 30% for transplant recipients and 23% for wait-listed patients (RR = 0.70 and 0.77; P < 0.0001 each). Slope analysis of the cause-specific mortality rates for cardiovascular disease and infection showed nearly equivalent, linear decreases for both groups. Mortality rates have improved overall and by categories of major cause of death for both renal transplant recipients and patients on the renal transplant waiting list. These favorable trends most likely represent equal advances in transplantation, dialysis, and general medical care.

scholarly journals Characteristics and Outcomes of Renal Transplant Recipients With Hemolytic Uremic Syndrome in the United States

2015 ◽  
Vol 1 (10) ◽  
pp. e41 ◽  
Author(s):  
Bekir Tanriover ◽  
Ronak Lakhia ◽  
Yu-Min Shen ◽  
Burhaneddin Sandikci ◽  
Ramesh Saxena ◽  
...  
Keyword(s):  
United States ◽  
Renal Transplant ◽  
Hemolytic Uremic Syndrome ◽  
The United States ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Uremic Syndrome

Human BK Polyomavirus Nephropathy (BKVN) In Non- Kidney-Transplant Patients

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S118-S118
Author(s):  
Y Chen Wongworawat ◽  
C Zuppan
Keyword(s):  
Renal Transplant ◽  
Kidney Transplant ◽  
Graft Loss ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Transplant Patients ◽  
Bk Polyomavirus ◽  
Pathologic Features ◽  
Renal Biopsies ◽  
Renal Transplant Patients

Abstract Introduction/Objective Human BK polyomavirus nephropathy (BKVN) occurs in up to 10% of renal transplant recipients, and can result in graft loss. Transplant biopsy is the gold standard to diagnose BKVN, and SV40 immunohistochemical (IHC) staining is helpful in confirming the diagnosis. BKVN is uncommon outside the setting of renal transplantation. To understand more about its occurrence in other contexts, we reviewed our renal biopsies files for cases of BKVN. Methods Our renal biopsy files for the past 20 years were reviewed for all cases with a diagnosis of BKVN or polyoma virus infection, and the clinical characteristics of the affected patients noted. Results Evidence of BKVN was found in 44 renal biopsies, of which 39 (86%) were renal transplant patients. Of the remaining five patients (14%), two had undergone heart transplantation, one lung transplantation, one was undergoing chemotherapy for acute lymphoblastic leukemia, and one patient had active HIV infection. All patients had elevated serum creatinine, and four out of five patients had documented BK viremia. Four of the five biopsies showed typical tubular injury with viral nuclear cytopathic changes (inclusions). In the lung transplant patient, the biopsy showed advanced chronic tubulointerstitial injury without distinct viral inclusions, but SV40 staining confirmed the presence of BK virus antigen. Conclusion The BKVN is distinctly uncommon outside the context of kidney transplantation. In our series, 14% of patients with BKVN were not kidney transplant recipients, but all were immune compromised in some fashion. The pathologic features of BKVN appear similar, regardless of whether the host is a renal transplant recipient or not. Although uncommon, it is important to consider the possibility of BKVN in non-renal transplant patients with persistent or progressive renal dysfunction.

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