Safety evaluation of chimeric Langat/Dengue 4 flavivirus, a live vaccine candidate against tick-borne encephalitis

2009 ◽  
Vol 81 (10) ◽  
pp. 1777-1785 ◽  
Author(s):  
Natalia S. Pripuzova ◽  
Natalia V. Tereshkina ◽  
Larissa V. Gmyl ◽  
Tatiana I. Dzhivanyan ◽  
Alexander A. Rumyantsev ◽  
...  
Keyword(s):  
Vaccine Candidate ◽  
Safety Evaluation ◽  
Live Vaccine ◽  
Tick Borne Encephalitis

Construction and characterization of a replication-competent human adenovirus type 3-based vector as a live-vaccine candidate and a viral delivery vector

Vaccine ◽  
2009 ◽  
Vol 27 (8) ◽  
pp. 1145-1153 ◽  
Author(s):  
Qiwei Zhang ◽  
Xiaobo Su ◽  
Donald Seto ◽  
Bo-jian Zheng ◽  
Xingui Tian ◽  
...  
Keyword(s):  
Vaccine Candidate ◽  
Human Adenovirus ◽  
Adenovirus Type ◽  
Live Vaccine ◽  
Delivery Vector ◽  
Type 3

Development of an attenuated live vaccine candidate of duck Tembusu virus strain

2019 ◽  
Vol 231 ◽  
pp. 218-225 ◽  
Author(s):  
Dalin He ◽  
Xin Zhang ◽  
Lin Chen ◽  
Yi Tang ◽  
Youxiang Diao
Keyword(s):  
Virus Strain ◽  
Vaccine Candidate ◽  
Live Vaccine ◽  
Duck Tembusu Virus ◽  
Tembusu Virus

scholarly journals Developmental and reproductive safety evaluation of AV7909 anthrax vaccine candidate in rats

2020 ◽  
Vol 113 (1) ◽  
pp. 32-42
Author(s):  
Eve Mylchreest ◽  
M. Autumn Smiley ◽  
Jeff D. Ballin ◽  
Bruna Blauth ◽  
Jeffry Shearer ◽  
...  
Keyword(s):  
Vaccine Candidate ◽  
Safety Evaluation ◽  
Anthrax Vaccine

Assessment of a vaccinia virus vectored multi-epitope live vaccine candidate for Plasmodium falciparum

2001 ◽  
Vol 31 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Wenqi Dong ◽  
Ming Li ◽  
Huixiang Bi ◽  
Yingjie Li ◽  
Jun Wu ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Vaccinia Virus ◽  
Vaccine Candidate ◽  
Live Vaccine

Salmonella Typhimurium lacking phoBR as a live vaccine candidate against poultry infection

2022 ◽  
pp. 109342
Author(s):  
Bogyo Jung ◽  
Soyeon Park ◽  
Eunsuk Kim ◽  
Hyunjin Yoon ◽  
Tae-Wook Hahn
Keyword(s):  
Salmonella Typhimurium ◽  
Vaccine Candidate ◽  
Live Vaccine

Evaluation of avian influenza virus isolated from ducks as a potential live vaccine candidate against novel H7N9 viruses

Vaccine ◽  
2014 ◽  
Vol 32 (48) ◽  
pp. 6433-6439 ◽  
Author(s):  
Wen-Ming Jiang ◽  
Su-Chun Wang ◽  
Hua-Lei Liu ◽  
Jian-Min Yu ◽  
Xiang Du ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Vaccine Candidate ◽  
Live Vaccine

Isolation and characterization of a naturally attenuated novel duck reovirus strain as a live vaccine candidate

2021 ◽  
Vol 261 ◽  
pp. 109214
Author(s):  
Hui Yan ◽  
Guige Xu ◽  
Yanli Zhu ◽  
Zhijing Xie ◽  
Ruihua Zhang ◽  
...  
Keyword(s):  
Vaccine Candidate ◽  
Live Vaccine ◽  
Isolation And Characterization

scholarly journals The Brucella abortus S19 ΔvjbR Live Vaccine Candidate Is Safer than S19 and Confers Protection against Wild-Type Challenge in BALB/c Mice When Delivered in a Sustained-Release Vehicle

2008 ◽  
Vol 77 (2) ◽  
pp. 877-884 ◽  
Author(s):  
A. M. Arenas-Gamboa ◽  
T. A. Ficht ◽  
M. M. Kahl-McDonagh ◽  
G. Gomez ◽  
A. C. Rice-Ficht
Keyword(s):  
Sustained Release ◽  
Vaccine Candidate ◽  
Fasciola Hepatica ◽  
Protective Efficacy ◽  
Small Ruminants ◽  
Live Vaccine ◽  
Worldwide Distribution ◽  
Humoral Responses ◽  
S19 Vaccine ◽  
Potential Use

ABSTRACT Brucellosis is an important zoonotic disease of nearly worldwide distribution. Despite the availability of live vaccine strains for bovine (S19, RB51) and small ruminants (Rev-1), these vaccines have several drawbacks, including residual virulence for animals and humans. Safe and efficacious immunization systems are therefore needed to overcome these disadvantages. A vjbR knockout was generated in the S19 vaccine and investigated for its potential use as an improved vaccine candidate. Vaccination with a sustained-release vehicle to enhance vaccination efficacy was evaluated utilizing the live S19 ΔvjbR::Kan in encapsulated alginate microspheres containing a nonimmunogenic eggshell precursor protein of the parasite Fasciola hepatica (vitelline protein B). BALB/c mice were immunized intraperitoneally with either encapsulated or nonencapsulated S19 ΔvjbR::Kan at a dose of 1 × 105 CFU per animal to evaluate immunogenicity, safety, and protective efficacy. Humoral responses postvaccination indicate that the vaccine candidate was able to elicit an anti-Brucella-specific immunoglobulin G response even when the vaccine was administered in an encapsulated format. The safety was revealed by the absence of splenomegaly in mice that were inoculated with the mutant. Finally, a single dose with the encapsulated mutant conferred higher levels of protection compared to the nonencapsulated vaccine. These results suggest that S19 ΔvjbR::Kan is safer than S19, induces protection in mice, and should be considered as a vaccine candidate when administered in a sustained-release manner.

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