Development and evaluation of in murine model, of an improved live-vaccine candidate against brucellosis from to Brucella melitensis vjbR deletion mutant

2018 ◽  
Vol 124 ◽  
pp. 250-257 ◽  
Author(s):  
Zhiqiang Li ◽  
Shuli Wang ◽  
Hui Zhang ◽  
Li Xi ◽  
Jinliang Zhang ◽  
...  
Keyword(s):  
Murine Model ◽  
Deletion Mutant ◽  
Vaccine Candidate ◽  
Brucella Melitensis ◽  
Live Vaccine

scholarly journals The role ofrpoS,hmp, andssrABinSalmonella entericaGallinarum and evaluation of a triple-deletion mutant as a live vaccine candidate in Lohmann layer chickens

2015 ◽  
Vol 16 (2) ◽  
pp. 187 ◽  
Author(s):  
Youngjae Cho ◽  
Yoon Mee Park ◽  
Abhijit Kashinath Barate ◽  
So-Yeon Park ◽  
Hee Jeong Park ◽  
...  
Keyword(s):  
Deletion Mutant ◽  
Vaccine Candidate ◽  
Live Vaccine ◽  
Layer Chickens

The Brucella melitensis M5-90ΔmanB live vaccine candidate is safer than M5-90 and confers protection against wild-type challenge in BALB/c mice

2017 ◽  
Vol 112 ◽  
pp. 148-155 ◽  
Author(s):  
Junbo Zhang ◽  
Shuanghong Yin ◽  
Dewu Yi ◽  
Hong Zhang ◽  
Zhiqiang Li ◽  
...  
Keyword(s):  
Vaccine Candidate ◽  
Brucella Melitensis ◽  
Live Vaccine ◽  
Wild Type

Improvement of the attenuated mutant strain of Brucella melitensis Rev1 as a potential vaccine candidate

Biologia ◽  
2021 ◽  
Author(s):  
Elham Mehdizadeh Marzenaki ◽  
Ali Reza Saeedinia ◽  
Mehdi Zeinoddini ◽  
Ali Asghar Deldar
Keyword(s):  
Mutant Strain ◽  
Vaccine Candidate ◽  
Brucella Melitensis ◽  
Potential Vaccine Candidate ◽  
Potential Vaccine

scholarly journals Construction of Brucella melitensis ghost as a putative vaccine candidate against re-emerging disease – Brucellosis

2020 ◽  
Vol 101 ◽  
pp. 475-476
Author(s):  
B. Sumathi ◽  
B. Veeregowda ◽  
S. Byregowda ◽  
D. Rathnamma ◽  
S. Rajeswari ◽  
...  
Keyword(s):  
Vaccine Candidate ◽  
Brucella Melitensis ◽  
Emerging Disease

scholarly journals Deletion of znuA Virulence Factor Attenuates Brucella abortus and Confers Protection against Wild-Type Challenge

2006 ◽  
Vol 74 (7) ◽  
pp. 3874-3879 ◽  
Author(s):  
Xinghong Yang ◽  
Todd Becker ◽  
Nancy Walters ◽  
David W. Pascual
Keyword(s):  
Brucella Abortus ◽  
Deletion Mutant ◽  
Pasteurella Multocida ◽  
Brucella Melitensis ◽  
Normal Growth ◽  
Wild Type ◽  
Minimal Growth ◽  
M Genome ◽  
S19 Vaccine ◽  
Knockout Mutation

ABSTRACT znuA is known to be an important factor for survival and normal growth under low Zn2+ concentrations for Escherichia coli, Haemophilus spp., Neisseria gonorrhoeae, and Pasteurella multocida. We hypothesized that the znuA gene present in Brucella melitensis 16 M would be similar to znuA in B. abortus and questioned whether it may also be an important factor for growth and virulence of Brucella abortus. Using the B. melitensis 16 M genome sequence, primers were designed to construct a B. abortus deletion mutant. A znuA knockout mutation in B. abortus 2308 (ΔznuA) was constructed and found to be lethal in low-Zn2+ medium. When used to infect macrophages, ΔznuA B. abortus showed minimal growth. Further study with ΔznuA B. abortus showed that its virulence in BALB/c mice was attenuated, and most of the bacteria were cleared from the spleen within 8 weeks. Protection studies confirmed the ΔznuA mutant as a potential live vaccine, since protection against wild-type B. abortus 2308 challenge was as effective as that obtained with the RB51 or S19 vaccine strain.

Construction and characterization of a replication-competent human adenovirus type 3-based vector as a live-vaccine candidate and a viral delivery vector

Vaccine ◽  
2009 ◽  
Vol 27 (8) ◽  
pp. 1145-1153 ◽  
Author(s):  
Qiwei Zhang ◽  
Xiaobo Su ◽  
Donald Seto ◽  
Bo-jian Zheng ◽  
Xingui Tian ◽  
...  
Keyword(s):  
Vaccine Candidate ◽  
Human Adenovirus ◽  
Adenovirus Type ◽  
Live Vaccine ◽  
Delivery Vector ◽  
Type 3

Development of an attenuated live vaccine candidate of duck Tembusu virus strain

2019 ◽  
Vol 231 ◽  
pp. 218-225 ◽  
Author(s):  
Dalin He ◽  
Xin Zhang ◽  
Lin Chen ◽  
Yi Tang ◽  
Youxiang Diao
Keyword(s):  
Virus Strain ◽  
Vaccine Candidate ◽  
Live Vaccine ◽  
Duck Tembusu Virus ◽  
Tembusu Virus

scholarly journals Shedding of Brucella melitensis happens through milk macrophages in the murine model of infection

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Wiebke Jansen ◽  
Aurore Demars ◽  
Charles Nicaise ◽  
Jacques Godfroid ◽  
Xavier de Bolle ◽  
...  
Keyword(s):  
Murine Model ◽  
Brucella Melitensis

Immunotherapy of prostate cancer in a murine model using a novel GnRH based vaccine candidate

Vaccine ◽  
2007 ◽  
Vol 25 (50) ◽  
pp. 8460-8468 ◽  
Author(s):  
Jesús A. Junco ◽  
Peter Peschke ◽  
Ivan Zuna ◽  
Volker Ehemann ◽  
Franklin Fuentes ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Murine Model ◽  
Vaccine Candidate
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