Interrupting wild poliovirus transmission using oral poliovirus vaccine: Environmental surveillance in high-risks area of India

2008 ◽  
Vol 80 (8) ◽  
pp. 1477-1488 ◽  
Author(s):  
Rashmi Chowdhary ◽  
T.N. Dhole
Keyword(s):  
Oral Poliovirus Vaccine ◽  
Environmental Surveillance ◽  
Wild Poliovirus

scholarly journals Inferring Numbers of Wild Poliovirus Excretors Using Quantitative Environmental Surveillance

Vaccines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 870
Author(s):  
Yuri Perepliotchikov ◽  
Tomer Ziv-Baran ◽  
Musa Hindiyeh ◽  
Yossi Manor ◽  
Danit Sofer ◽  
...  
Keyword(s):  
Oral Polio Vaccine ◽  
Turnaround Time ◽  
Quantitative Detection ◽  
Environmental Surveillance ◽  
Wild Poliovirus ◽  
Polio Vaccine ◽  
Kinetic Information ◽  
Using Data ◽  
Number Of Individuals

Response to and monitoring of viral outbreaks can be efficiently focused when rapid, quantitative, kinetic information provides the location and the number of infected individuals. Environmental surveillance traditionally provides information on location of populations with contagious, infected individuals since infectious poliovirus is excreted whether infections are asymptomatic or symptomatic. Here, we describe development of rapid (1 week turnaround time, TAT), quantitative RT-PCR of poliovirus RNA extracted directly from concentrated environmental surveillance samples to infer the number of infected individuals excreting poliovirus. The quantitation method was validated using data from vaccination with bivalent oral polio vaccine (bOPV). The method was then applied to infer the weekly number of excreters in a large, sustained, asymptomatic outbreak of wild type 1 poliovirus in Israel (2013) in a population where >90% of the individuals received three doses of inactivated polio vaccine (IPV). Evidence-based intervention strategies were based on the short TAT for direct quantitative detection. Furthermore, a TAT shorter than the duration of poliovirus excretion allowed resampling of infected individuals. Finally, the method documented absence of infections after successful intervention of the asymptomatic outbreak. The methodologies described here can be applied to outbreaks of other excreted viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), where there are (1) significant numbers of asymptomatic infections; (2) long incubation times during which infectious virus is excreted; and (3) limited resources, facilities, and manpower that restrict the number of individuals who can be tested and re-tested.

scholarly journals Environmental Surveillance System To Track Wild Poliovirus Transmission

2003 ◽  
Vol 69 (5) ◽  
pp. 2919-2927 ◽  
Author(s):  
Jagadish M. Deshpande ◽  
Sushmitha J. Shetty ◽  
Zaeem A. Siddiqui
Keyword(s):  
Environmental Samples ◽  
Uttar Pradesh ◽  
Immunization Coverage ◽  
Paralytic Poliomyelitis ◽  
Nucleotide Sequence Analysis ◽  
Environmental Surveillance ◽  
Poliovirus Type ◽  
Wild Poliovirus ◽  
Supplementary Immunization Activities ◽  
Type 3

ABSTRACT Eradication of poliomyelitis from large metropolis cities in India has been difficult due to high population density and the presence of large urban slums. Three paralytic poliomyelitis cases were reported in Mumbai, India, in 1999 and 2000 in spite of high immunization coverage and good-quality supplementary immunization activities. We therefore established a systematic environmental surveillance study by weekly screening of sewage samples from three high-risk slum areas to detect the silent transmission of wild poliovirus. In 2001, from among the 137 sewage samples tested, wild poliovirus type 1 was isolated from 35 and wild poliovirus type 3 was isolated from 1. Acute flaccid paralysis (AFP) surveillance indicated one case of paralytic poliomyelitis from the city. Phylogenetic analysis with complete VP1 sequences revealed that the isolates from environmental samples belonged to four lineages of wild polioviruses recently isolated from poliomyelitis cases in Uttar Pradesh and not to those previously isolated from AFP cases in Mumbai. Wild poliovirus thus introduced caused one case of paralytic poliomyelitis. The virus was detected in environmental samples 3 months before. It was found that wild polioviruses introduced several times during the year circulated in Mumbai for a limited period before being eliminated. Environmental surveillance was found to be sensitive for the detection of wild poliovirus silent transmission. Nucleotide sequence analysis helped identify wild poliovirus reservoir areas.

scholarly journals Environmental Surveillance of Polioviruses in Armenia, Colombia before Trivalent Oral Polio Vaccine Cessation

Viruses ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 775
Author(s):  
María Mercedes González ◽  
Magile C. Fonseca ◽  
Carlos Andrés Rodríguez ◽  
Alejandra María Giraldo ◽  
José Joaquín Vila ◽  
...  
Keyword(s):  
Transition Period ◽  
Virus Detection ◽  
Oral Polio Vaccine ◽  
Supplementary Information ◽  
Paralytic Poliomyelitis ◽  
Environmental Surveillance ◽  
Wild Poliovirus ◽  
Polio Vaccine ◽  
Afp Surveillance ◽  
Wastewater Samples

Although acute flaccid paralysis (AFP) surveillance is the “gold standard” for detecting cases of polio, environmental surveillance can provide supplementary information in the absence of paralytic poliomyelitis cases. This study aimed to detect the introduction and/or circulation of wild poliovirus or vaccine-derived polioviruses (VDPV) in wastewater, covering a significant population of Armenia, Colombia, before trivalent oral polio vaccine (OPV) cessation. Between March and September 2015, 24 wastewater samples were collected from eight study sites in eight communes of Armenia, Colombia. Virus detection and characterization were performed using both cell culture (i.e., RD or L20B cells) and RT-PCR. Polioviruses were isolated in 11 (45.8%) of 24 wastewater samples. All isolates were identified as Sabin strains (type 1 = 9, type 3 = 2) by intratypic differentiation. Type 2 poliovirus was not detected in any of the samples. No wild poliovirus or VDPV was detected among the isolates. Non-polio enterovirus was identified in 8.3% (2/24) of the samples. This study revealed the excretion of Sabin poliovirus from OPV-immunized individuals, as well as the absence of VDPV and wild poliovirus in wastewaters of Armenia, Colombia. This confirms that environmental surveillance is an effective method, as an additional support to AFP surveillance, to monitor poliovirus during the OPV-to-IPV (inactivated polio vaccine) transition period.

scholarly journals Detection of Imported Wild Polioviruses and of Vaccine-Derived Polioviruses by Environmental Surveillance in Egypt

2012 ◽  
Vol 78 (15) ◽  
pp. 5406-5409 ◽  
Author(s):  
Soile Blomqvist ◽  
Laila El Bassioni ◽  
Eman M. El Maamoon Nasr ◽  
Anja Paananen ◽  
Svetlana Kaijalainen ◽  
...  
Keyword(s):  
Acute Flaccid Paralysis ◽  
Polio Eradication ◽  
Flaccid Paralysis ◽  
Environmental Surveillance ◽  
Wild Type ◽  
Wild Poliovirus ◽  
Afp Surveillance

ABSTRACTSystematic environmental surveillance for poliovirus circulation has been conducted in Egypt since 2000. The surveillance has revealed three independent importations of wild-type poliovirus. In addition, several vaccine-derived polioviruses have been detected in various locations in Egypt. In addition to acute flaccid paralysis (AFP) surveillance, environmental surveillance can be used to monitor the wild poliovirus and vaccine-derived poliovirus circulation in populations in support of polio eradication initiatives.

scholarly journals Detection of Multiple Cocirculating Wild Poliovirus Type 1 Lineages Through Environmental Surveillance: Impact and Progress During 2011–2013 in Pakistan

2014 ◽  
Vol 210 (suppl_1) ◽  
pp. S324-S332 ◽  
Author(s):  
Muhammad Masroor Alam ◽  
Shahzad Shaukat ◽  
Salmaan Sharif ◽  
Mehar Angez ◽  
Adnan Khurshid ◽  
...  
Keyword(s):  
Environmental Surveillance ◽  
Poliovirus Type ◽  
Wild Poliovirus

Genetic Epidemiology Reveals 3 Chronic Reservoir Areas With Recurrent Population Mobility Challenging Poliovirus Eradication in Pakistan

2019 ◽  
Vol 71 (7) ◽  
pp. e58-e67 ◽  
Author(s):  
Ribqa Akhtar ◽  
Nayab Mahmood ◽  
Muhammad Masroor Alam ◽  
Muhammad Naeem ◽  
Syed Sohail Zahoor Zaidi ◽  
...  
Keyword(s):  
Genetic Relatedness ◽  
Immunization Coverage ◽  
Polio Eradication ◽  
Genomic Diversity ◽  
Environmental Surveillance ◽  
Population Mobility ◽  
Coding Region ◽  
Wild Poliovirus ◽  
Effective Combination

Abstract Background Pakistan is among 3 countries endemic for wild poliovirus type 1 (WPV1) circulation that are still struggling for eradication of poliomyelitis. Active clinical and environmental surveillance with meticulous laboratory investigations provide insights into poliovirus transmission patterns and genomic diversity to inform decisions for strategic operations required to achieve eradication. Methods We analyzed epidemiological and virological data to comprehend the current epidemiological status of WPV1 in Pakistan during 2015–2017. Stool specimens of patients with acute flaccid paralysis (AFP) and sewage samples collected from 60 environmental sites were tested. Viral culturing, intratypic differentiation by real-time polymerase chain reaction, and nucleic acid sequencing of the VP1 region of the poliovirus genome to determine genetic relatedness among WPV1 strains were applied. Results Poliovirus isolates were grouped into 11 distinct clusters, which had ≥95% nucleotide homology in the VP1 coding region. Most of the poliovirus burden was shared by 3 major reservoirs: Karachi, Peshawar, and Quetta block (64.2% in 2015, 75.4% in 2016, and 76.7% in 2017). Conclusions Environmental surveillance reveals importations and pockets of unimmunized children that dictate intensive target mop-up campaigns to contain poliovirus transmission. A decrease in the number of orphan isolates reflects effective combination of AFP and environmental surveillance in Pakistan. The genetic data reflect sustained transmission within reservoir areas, further expanded by periodic importations to areas of high immunity reflected by immediate termination of imported viruses. Improved immunization coverage with high-quality surveillance is vital for global certification of polio eradication.

scholarly journals Seroprevalence of Antipolio Antibodies among Children <15 Years of Age in Border Provinces in China

2013 ◽  
Vol 20 (7) ◽  
pp. 1070-1075 ◽  
Author(s):  
HaiBo Wang ◽  
Hui Cui ◽  
ZhengRong Ding ◽  
Pian Ba ◽  
ShuangLi Zhu ◽  
...  
Keyword(s):  
Neutralizing Antibody ◽  
Polio Eradication ◽  
Oral Poliovirus Vaccine ◽  
World Health ◽  
Cross Sectional ◽  
Autonomous Region ◽  
Wild Poliovirus ◽  
Xinjiang Uygur Autonomous Region ◽  
Tibet Autonomous Region ◽  
Antibody Titers

ABSTRACTDespite remarkable progression toward polio eradication worldwide, wild poliovirus (WPV) importation has been a great challenge for China, as it shares borders with countries where WPV is endemic. The objective of this study was to estimate poliovirus antibody seroprevalence among children <15 years of age in 3 border provinces (Yunnan Province, Tibet Autonomous Region, and Xinjiang Uygur Autonomous Region) in China. A cross-sectional, hospital-based study was undertaken in 3 border provinces in 2010. Individuals <15 years old who visited hospitals at the prefecture level or above to have their blood drawn for any reason were invited to participate in our study. Neutralizing antibody titers to polio serotypes 1 (P1), P2, and P3 were assayed according to the World Health Organization manual for the virological investigation of polio. Antibody titers of ≥8 were considered positive. Among the 1,360 subjects enrolled, 1,220 (89.7%), 1,259 (92.6%), and 1,112 (81.8%) were seropositive to P1, P2, and P3, respectively, and 1,051 (77.3%) subjects were seropositive to all three serotypes. The highest seropositive rates were observed in Xinjiang Uygur Autonomous Region. By age, 3- to 5-year-old subjects had the highest rate of seropositivity, and seropositivity decreased significantly with increasing age. The risk of WPV importation will continue until WPV transmission has been interrupted worldwide. Consistent with the Global Polio Eradication Initiative's polio endgame strategy, China must maintain its polio-free status by ensuring adequate population immunity against polio. Because immunity wanes with increasing age, a booster dose with bivalent type 1 and 2 oral poliovirus vaccine could be considered for teenagers in China.

scholarly journals Isolation of epidemic poliovirus from sewage during the 1992–3 type 3 outbreak in the Netherlands

1995 ◽  
Vol 114 (3) ◽  
pp. 481-491 ◽  
Author(s):  
H. G. A. M. van der Avoort ◽  
J. H. J. Reimerink ◽  
A. Ras ◽  
M. N. Mulders ◽  
A. M. van Loon
Keyword(s):  
The Netherlands ◽  
Oral Poliovirus Vaccine ◽  
Wild Type ◽  
Risk Area ◽  
Poliovirus Type ◽  
Wild Poliovirus ◽  
Home Village ◽  
A Site ◽  
Religious Reasons ◽  
Type 3

SUMMARYTo examine the extent of wild poliovirus circulation during the 1992–3 epidemic in the Netherlands caused by poliovirus type 3, 269 samples from sewage pipelines at 120 locations were examined for the presence of poliovirus. The epidemic virus strain was found in 23 samples, all from locations inside the risk area which contained communities that refuse vaccination for religious reasons. By sewage investigation, the wildtype virus was shown to be present in the early phase of the epidemic at two locations, one week before patients were reported from that area. The wild type 3 poliovirus was also detected retrospectively in a river water sample collected for other reasons three weeks before notification of the first poliomyelitis case, at a site a few kilometres upstream the home village of this patient. Oral poliovirus vaccine (OPV) virus was found at 28 locations inside or at the border of the risk area. Trivalent OPV was offered to unvaccinated or incompletely-vaccinated persons living in this region as part of the measures to control the epidemic.

scholarly journals Epidemiology of the silent polio outbreak in Rahat, Israel, based on modeling of environmental surveillance data

2018 ◽  
Vol 115 (45) ◽  
pp. E10625-E10633 ◽  
Author(s):  
Andrew F. Brouwer ◽  
Joseph N. S. Eisenberg ◽  
Connor D. Pomeroy ◽  
Lester M. Shulman ◽  
Musa Hindiyeh ◽  
...  
Keyword(s):  
Disease Transmission ◽  
Disease Surveillance ◽  
Quantitative Polymerase Chain Reaction ◽  
Vaccination Campaign ◽  
Polio Eradication ◽  
Environmental Data ◽  
Transmission Model ◽  
Environmental Surveillance ◽  
Wild Poliovirus ◽  
Polio Vaccination

Israel experienced an outbreak of wild poliovirus type 1 (WPV1) in 2013–2014, detected through environmental surveillance of the sewage system. No cases of acute flaccid paralysis were reported, and the epidemic subsided after a bivalent oral polio vaccination (bOPV) campaign. As we approach global eradication, polio will increasingly be detected only through environmental surveillance. We developed a framework to convert quantitative polymerase chain reaction (qPCR) cycle threshold data into scaled WPV1 and OPV1 concentrations for inference within a deterministic, compartmental infectious disease transmission model. We used this approach to estimate the epidemic curve and transmission dynamics, as well as assess alternate vaccination scenarios. Our analysis estimates the outbreak peaked in late June, much earlier than previous estimates derived from analysis of stool samples, although the exact epidemic trajectory remains uncertain. We estimate the basic reproduction number was 1.62 (95% CI 1.04–2.02). Model estimates indicate that 59% (95% CI 9–77%) of susceptible individuals (primarily children under 10 years old) were infected with WPV1 over a little more than six months, mostly before the vaccination campaign onset, and that the vaccination campaign averted 10% (95% CI 1–24%) of WPV1 infections. As we approach global polio eradication, environmental monitoring with qPCR can be used as a highly sensitive method to enhance disease surveillance. Our analytic approach brings public health relevance to environmental data that, if systematically collected, can guide eradication efforts.

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