Dengue virus infection of human microvascular endothelial cells from different vascular beds promotes both common and specific functional changes

2005 ◽  
Vol 78 (2) ◽  
pp. 229-242 ◽  
Author(s):  
Christophe N. Peyrefitte ◽  
Boris Pastorino ◽  
Georges E. Grau ◽  
J. Lou ◽  
Hugues Tolou ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Virus Infection ◽  
Dengue Virus ◽  
Microvascular Endothelial Cells ◽  
Dengue Virus Infection ◽  
Functional Changes ◽  
Vascular Beds ◽  
Microvascular Endothelial

scholarly journals Ubiquinone Metabolism and Transcription HIF-1 Targets Pathway Are Toxicity Signature Pathways Present in Extracellular Vesicles of Paraquat-Exposed Human Brain Microvascular Endothelial Cells

2021 ◽  
Vol 22 (10) ◽  
pp. 5065
Author(s):  
Tatjana Vujić ◽  
Domitille Schvartz ◽  
Anton Iliuk ◽  
Jean-Charles Sanchez
Keyword(s):  
Endothelial Cells ◽  
Human Brain ◽  
Extracellular Vesicles ◽  
Physiological State ◽  
Microvascular Endothelial Cells ◽  
Brain Microvascular Endothelial Cells ◽  
Cell Of Origin ◽  
Functional Changes ◽  
Data Independent Acquisition ◽  
Microvascular Endothelial

Over the last decade, the knowledge in extracellular vesicles (EVs) biogenesis and modulation has increasingly grown. As their content reflects the physiological state of their donor cells, these “intercellular messengers” progressively became a potential source of biomarker reflecting the host cell state. However, little is known about EVs released from the human brain microvascular endothelial cells (HBMECs). The current study aimed to isolate and characterize EVs from HBMECs and to analyze their EVs proteome modulation after paraquat (PQ) stimulation, a widely used herbicide known for its neurotoxic effect. Size distribution, concentration and presence of well-known EV markers were assessed. Identification and quantification of PQ-exposed EV proteins was conducted by data-independent acquisition mass spectrometry (DIA-MS). Signature pathways of PQ-treated EVs were analyzed by gene ontology terms and pathway enrichment. Results highlighted that EVs exposed to PQ have modulated pathways, namely the ubiquinone metabolism and the transcription HIF-1 targets. These pathways may be potential molecular signatures of the PQ-induced toxicity carried by EVs that are reflecting their cell of origin by transporting with them irreversible functional changes.

scholarly journals The Ubiquitin−Proteasome Pathway Is Important for Dengue Virus Infection in Primary Human Endothelial Cells

2010 ◽  
Vol 9 (10) ◽  
pp. 4960-4971 ◽  
Author(s):  
Rattiyaporn Kanlaya ◽  
Sa-nga Pattanakitsakul ◽  
Supachok Sinchaikul ◽  
Shui-Tein Chen ◽  
Visith Thongboonkerd
Keyword(s):  
Endothelial Cells ◽  
Virus Infection ◽  
Dengue Virus ◽  
Human Endothelial Cells ◽  
Dengue Virus Infection ◽  
Ubiquitin Proteasome Pathway ◽  
Ubiquitin Proteasome ◽  
Proteasome Pathway

scholarly journals Senescence Affects Endothelial Cells Susceptibility to Dengue Virus Infection

2014 ◽  
Vol 11 (6) ◽  
pp. 538-544 ◽  
Author(s):  
Sazaly AbuBakar ◽  
Meng-Hooi Shu ◽  
Jefree Johari ◽  
Pooi-Fong Wong
Keyword(s):  
Endothelial Cells ◽  
Virus Infection ◽  
Dengue Virus ◽  
Dengue Virus Infection

scholarly journals Dengue Virus Infection Mediates HMGB1 Release from Monocytes Involving PCAF Acetylase Complex and Induces Vascular Leakage in Endothelial Cells

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e41932 ◽  
Author(s):  
Siew Pei Ong ◽  
Ling Min Lee ◽  
Yew Fai Ivan Leong ◽  
Mah Lee Ng ◽  
Justin Jang Hann Chu
Keyword(s):  
Endothelial Cells ◽  
Virus Infection ◽  
Dengue Virus ◽  
Vascular Leakage ◽  
Dengue Virus Infection

Tissue plasminogen activator induced by dengue virus infection of human endothelial cells

2003 ◽  
Vol 70 (4) ◽  
pp. 610-616 ◽  
Author(s):  
Ying-Huey Huang ◽  
Huan-Yao Lei ◽  
Hsiao-Sheng Liu ◽  
Yee-Shin Lin ◽  
Shun-Hua Chen ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Virus Infection ◽  
Dengue Virus ◽  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Human Endothelial Cells ◽  
Dengue Virus Infection ◽  
Tissue Plasminogen

scholarly journals Bradykinin enhances Sindbis virus infection in human brain microvascular endothelial cells

Virology ◽  
2012 ◽  
Vol 422 (1) ◽  
pp. 81-91 ◽  
Author(s):  
Naiara Miranda Rust ◽  
Michelle Premazzi Papa ◽  
Aline Miranda Scovino ◽  
Mayara Marques Carneiro da Silva ◽  
Carlos Eduardo Calzavara-Silva ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Virus Infection ◽  
Human Brain ◽  
Sindbis Virus ◽  
Microvascular Endothelial Cells ◽  
Brain Microvascular Endothelial Cells ◽  
Microvascular Endothelial
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