scholarly journals An optimized method for the detection and spatial distribution of aminoglycoside and vancomycin antibiotics in tissue sections by mass spectrometry imaging

2021 ◽  
Vol 56 (3) ◽  
Author(s):  
Ning Wang ◽  
Véronique Dartois ◽  
Claire L. Carter
Keyword(s):  
Mass Spectrometry ◽  
Spatial Distribution ◽  
Mass Spectrometry Imaging ◽  
Tissue Sections

scholarly journals Unveiling the spatial distribution of aflatoxin B1 and plant defense metabolites in maize using AP‐SMALDI mass spectrometry imaging

2021 ◽  
Author(s):  
Laura Righetti ◽  
Dhaka Ram Bhandari ◽  
Enrico Rolli ◽  
Sara Tortorella ◽  
Renato Bruni ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Spatial Distribution ◽  
Plant Defense ◽  
Aflatoxin B1 ◽  
Mass Spectrometry Imaging

scholarly journals Exemplifying the Screening Power of Mass Spectrometry Imaging over Label-Based Technologies for Simultaneous Monitoring of Drug and Metabolite Distributions in Tissue Sections

2015 ◽  
Vol 21 (2) ◽  
pp. 187-193 ◽  
Author(s):  
Richard J. A. Goodwin ◽  
Anna Nilsson ◽  
C. Logan Mackay ◽  
John G. Swales ◽  
Maria K. Johansson ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Cyclic Peptide ◽  
Analysis Data ◽  
Resolving Power ◽  
High Mass ◽  
Whole Body ◽  
Ion Cyclotron Resonance ◽  
Label Free ◽  
Tissue Sections

Mass spectrometry imaging (MSI) provides pharmaceutical researchers with a suite of technologies to screen and assess compound distributions and relative abundances directly from tissue sections and offer insight into drug discovery–applicable queries such as blood-brain barrier access, tumor penetration/retention, and compound toxicity related to drug retention in specific organs/cell types. Label-free MSI offers advantages over label-based assays, such as quantitative whole-body autoradiography (QWBA), in the ability to simultaneously differentiate and monitor both drug and drug metabolites. Such discrimination is not possible by label-based assays if a drug metabolite still contains the radiolabel. Here, we present data exemplifying the advantages of MSI analysis. Data of the distribution of AZD2820, a therapeutic cyclic peptide, are related to corresponding QWBA data. Distribution of AZD2820 and two metabolites is achieved by MSI, which [14C]AZD2820 QWBA fails to differentiate. Furthermore, the high mass-resolving power of Fourier transform ion cyclotron resonance MS is used to separate closely associated ions.

Mass spectrometry imaging of pharmacological compounds in tissue sections

Bioanalysis ◽  
2010 ◽  
Vol 2 (2) ◽  
pp. 279-293 ◽  
Author(s):  
Richard JA Goodwin ◽  
Andrew R Pitt
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Tissue Sections

scholarly journals Spermidine and other functional phytochemicals in soybean seeds: Spatial distribution as visualized by mass spectrometry imaging

2019 ◽  
Vol 8 (1) ◽  
pp. 675-682 ◽  
Author(s):  
Tatsuya Sagara ◽  
Dhaka Ram Bhandari ◽  
Bernhard Spengler ◽  
Johann Vollmann
Keyword(s):  
Mass Spectrometry ◽  
Spatial Distribution ◽  
Mass Spectrometry Imaging ◽  
Soybean Seeds

scholarly journals Mass spectrometry imaging: linking molecule profiles to tissue spatial distribution

2013 ◽  
Vol 10 (1) ◽  
pp. 17-20 ◽  
Author(s):  
Hassan Dihazi ◽  
Rainer Bohrer ◽  
Olaf Jahn ◽  
Christof Lenz ◽  
Andrzej Majcherczyk ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Spatial Distribution ◽  
Mass Spectrometry Imaging
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