Mass spectrometry imaging of pharmacological compounds in tissue sections

Bioanalysis ◽  
2010 ◽  
Vol 2 (2) ◽  
pp. 279-293 ◽  
Author(s):  
Richard JA Goodwin ◽  
Andrew R Pitt
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Tissue Sections

scholarly journals Exemplifying the Screening Power of Mass Spectrometry Imaging over Label-Based Technologies for Simultaneous Monitoring of Drug and Metabolite Distributions in Tissue Sections

2015 ◽  
Vol 21 (2) ◽  
pp. 187-193 ◽  
Author(s):  
Richard J. A. Goodwin ◽  
Anna Nilsson ◽  
C. Logan Mackay ◽  
John G. Swales ◽  
Maria K. Johansson ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Cyclic Peptide ◽  
Analysis Data ◽  
Resolving Power ◽  
High Mass ◽  
Whole Body ◽  
Ion Cyclotron Resonance ◽  
Label Free ◽  
Tissue Sections

Mass spectrometry imaging (MSI) provides pharmaceutical researchers with a suite of technologies to screen and assess compound distributions and relative abundances directly from tissue sections and offer insight into drug discovery–applicable queries such as blood-brain barrier access, tumor penetration/retention, and compound toxicity related to drug retention in specific organs/cell types. Label-free MSI offers advantages over label-based assays, such as quantitative whole-body autoradiography (QWBA), in the ability to simultaneously differentiate and monitor both drug and drug metabolites. Such discrimination is not possible by label-based assays if a drug metabolite still contains the radiolabel. Here, we present data exemplifying the advantages of MSI analysis. Data of the distribution of AZD2820, a therapeutic cyclic peptide, are related to corresponding QWBA data. Distribution of AZD2820 and two metabolites is achieved by MSI, which [14C]AZD2820 QWBA fails to differentiate. Furthermore, the high mass-resolving power of Fourier transform ion cyclotron resonance MS is used to separate closely associated ions.

scholarly journals Mass Spectrometry Imaging of Drug Related Crystal-Like Structures in Formalin-Fixed Frozen and Paraffin-Embedded Rabbit Kidney Tissue Sections

2015 ◽  
Vol 27 (1) ◽  
pp. 117-123 ◽  
Author(s):  
Anne L. Bruinen ◽  
Cateau van Oevelen ◽  
Gert B. Eijkel ◽  
Marjolein Van Heerden ◽  
Filip Cuyckens ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Kidney Tissue ◽  
Rabbit Kidney ◽  
Tissue Sections ◽  
Formalin Fixed

Combination of micro X-ray fluorescence spectroscopy and time-of-flight secondary ion mass spectrometry imaging for the marker-free detection of CeO2 nanoparticles in tissue sections

2018 ◽  
Vol 33 (3) ◽  
pp. 491-501 ◽  
Author(s):  
Lothar Veith ◽  
Dörthe Dietrich ◽  
Antje Vennemann ◽  
Daniel Breitenstein ◽  
Carsten Engelhard ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Fluorescence Spectroscopy ◽  
Mass Spectrometry Imaging ◽  
Secondary Ion Mass Spectrometry ◽  
Ceo2 Nanoparticles ◽  
Important Goal ◽  
X Ray ◽  
Tissue Sections ◽  
Marker Free ◽  
Secondary Ion

The description of nanoparticle distributions in tissue and associated effects is an important goal of nanotoxicology.

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