Regiospecific addition of CH2O at the radical site of the˙CH2CH2OHCH3+ distonic ion

1995 ◽  
Vol 30 (12) ◽  
pp. 1747-1751 ◽  
Author(s):  
V. Troude ◽  
D. Leblanc ◽  
P. Mourgues ◽  
H. E. Audier
Keyword(s):  
Radical Site ◽  
Distonic Ion

Bimolecular reactions involving the radical site of the distonic ion ·CH2CH2CH2CO+

1993 ◽  
Vol 7 (5) ◽  
pp. 392-399 ◽  
Author(s):  
Krista M. Stirk ◽  
Rebecca L. Smith ◽  
Joe C. Orlowski ◽  
Hilkka I. Kenttämaa
Keyword(s):  
Bimolecular Reactions ◽  
Radical Site ◽  
Distonic Ion

scholarly journals Structure and mechanism of galactose oxidase. The free radical site.

1994 ◽  
Vol 269 (40) ◽  
pp. 25095-25105
Author(s):  
A.J. Baron ◽  
C. Stevens ◽  
C. Wilmot ◽  
K.D. Seneviratne ◽  
V. Blakeley ◽  
...  
Keyword(s):  
Free Radical ◽  
Galactose Oxidase ◽  
Radical Site

Generation of the distonic ion CH2NH3.bul.+: nucleophilic substitution of the ketene cation radical by ammonia and unimolecular decarbonylation of ionized acetamide

1987 ◽  
Vol 109 (16) ◽  
pp. 4810-4818 ◽  
Author(s):  
Thomas Drewello ◽  
Nikolaus Heinrich ◽  
Wilfried P. M. Maas ◽  
Nico M. M. Nibbering ◽  
Thomas Weiske ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Cation Radical ◽  
Distonic Ion

Unimolecular and Bimolecular Reactions of the .beta.-Distonic Ion CH3CH2OH+CH2CH2.bul.: An Experimental and Theoretical Study

1995 ◽  
Vol 99 (27) ◽  
pp. 10837-10846 ◽  
Author(s):  
Valerie Brenner ◽  
Arielle Milliet ◽  
Philippe Mourgues ◽  
Gilles Ohanessian ◽  
Henri-Edouard Audier
Keyword(s):  
Theoretical Study ◽  
Bimolecular Reactions ◽  
Distonic Ion

Identification of Tyr504 as an Alternative Tyrosyl Radical Site in Human Prostaglandin H Synthase-2†

Biochemistry ◽  
2004 ◽  
Vol 43 (6) ◽  
pp. 1560-1568 ◽  
Author(s):  
Corina E. Rogge ◽  
Wen Liu ◽  
Gang Wu ◽  
Lee-Ho Wang ◽  
Richard J. Kulmacz ◽  
...  
Keyword(s):  
Tyrosyl Radical ◽  
Prostaglandin H Synthase ◽  
Radical Site ◽  
Prostaglandin H

Multiple Hydrogen Shifts Leading to Ammonia Loss from the Molecular Ions of Cyanocyclohexanes

2002 ◽  
Vol 8 (6) ◽  
pp. 435-445 ◽  
Author(s):  
T.A. Molenaar-Langeveld ◽  
A.M. van der Burg ◽  
S. Ingemann
Keyword(s):  
Molecular Ions ◽  
Minor Importance ◽  
Deuterium Labeling ◽  
Ammonia Loss ◽  
Cis And Trans Isomers ◽  
Metastable Ions ◽  
Cyclohexadienyl Radical ◽  
A Minor ◽  
Cis And Trans ◽  
Distonic Ion

The loss of ammonia from the metastable molecular ions of cyclic cyano compounds has been examined with the use of deuterium labeling and tandem mass spectrometry. Loss of ammonia is significant for ionized cyanocyclohexane, 1-methyl-, 4-methyl-, 4-cyano-and 4-phenyl-cyanocyclohexanes, 4-cyanopiperidine, cyanocycloheptane and 2-cyanonorbornane. By contrast, loss of ammonia is of minor importance (or absent) for the molecular ions of cyanocyclopentane, 2-methyl-cyanocyclohexane, 1-phenyl-cyanocyclohexane, 1-cyanocyclohexene, 4-cyanotetrahydrothiopyran, 2-cyano-5-norbornene and isocyanocyclohexane. Deuterium labeling of cyanocyclohexane reveals the occurrence of an H-shift from the 4-position to the cyano function, followed by a 1,2-H shift from the 1-position to the C-atom of the newly-formed–CNH group. Subsequently, a series of H-shifts leads to a distonic ion that is formulated as an N-protonated methylamine attached to a cyclohexadienyl radical. Loss of ammonia ensues and leads to ionized toluene as indicated by collision-induced dissociation experiments. For 4-phenyl-cyanocyclohexane, the metastable ions of the cis- and trans-isomers display, essentially, the same unimolecular chemistry. Briefly, the labeling of 4-phenyl-cyanocyclohexane indicates the following: (i) the H atom at the 4-position of the cyclohexane ring is incorporated, to a minor extent, in the ammonia molecule, (ii) loss of NHD2 predominates in the reactions of the molecular ions of 2,2,6,6-d4-4-phenyl-cyanocyclohexane and (iii) the ionized 3,3,5-d3-labeled species expels mainly NH2D. In addition, the metastable molecular ions of the 4-[d5-phenyl]-cyanocyclohexane expel NH3 and NH2D in a ratio of 35:65. A mechanistic scheme is proposed that is consistent with the labeling results for 4-phenyl-cyanocyclohexane as well as the indicated formation of ionized 4-methylbiphenyl as the product ion of ammonia loss.

The Three-dimensional Structure of Mammalian Ribonucleotide Reductase Protein R2 Reveals a More-accessible Iron-radical Site thanEscherichia coliR2

1996 ◽  
Vol 262 (5) ◽  
pp. 706-720 ◽  
Author(s):  
Björn Kauppi ◽  
Bettina B. Nielsen ◽  
S. Ramaswamy ◽  
Ingrid Kjøller Larsen ◽  
Margareta Thelander ◽  
...  
Keyword(s):  
Ribonucleotide Reductase ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Radical Site ◽  
Three Dimensional Structure

scholarly journals The role of aspartate-235 in the binding of cations to an artificial cavity at the radical site of cytochromecperoxidase

1995 ◽  
Vol 4 (9) ◽  
pp. 1844-1850 ◽  
Author(s):  
Melissa M. Fitzgerald ◽  
Michelle L. Trester ◽  
Gerard M. Jensen ◽  
Duncan E. Mcree ◽  
David B. Goodin
Keyword(s):  
Radical Site ◽  
Artificial Cavity
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