scholarly journals Stromal Collagen Content in Breast Tumors Correlates With In Vivo Diffusion‐Weighted Imaging: A Comparison of Multi b ‐Value DWI With Histologic Specimen From Benign and Malignant Breast Lesions

2019 ◽  
Vol 51 (6) ◽  
pp. 1868-1878 ◽  
Author(s):  
Liv Egnell ◽  
Igor Vidić ◽  
Neil P. Jerome ◽  
Anna M. Bofin ◽  
Tone F. Bathen ◽  
...  
Keyword(s):  
Diffusion Weighted Imaging ◽  
Breast Tumors ◽  
B Value ◽  
Collagen Content ◽  
Breast Lesions ◽  
Diffusion Weighted ◽  
Malignant Breast ◽  
Stromal Collagen ◽  
Histologic Specimen

Effects of contrast-enhancement on diffusion weighted imaging and apparent diffusion coefficient measurements in 3-T magnetic resonance imaging of breast lesions

2017 ◽  
Vol 59 (8) ◽  
pp. 902-908
Author(s):  
Valentina Cipolla ◽  
Daniele Guerrieri ◽  
Giacomo Bonito ◽  
Simone Celsa ◽  
Carlo de Felice
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Diffusion Weighted Imaging ◽  
Breast Lesions ◽  
Post Contrast ◽  
Diffusion Weighted ◽  
Signed Rank ◽  
Apparent Diffusion ◽  
Malignant Breast ◽  
Adc Values

Background The effect of gadolinium-based contrast agents on diffusion-weighted imaging (DWI) measurements of breast lesions is still not clear. Purpose To investigate gadolinium effects on DWI and apparent diffusion coefficient (ADC) in breast lesions and normal parenchyma with 3 Tesla contrast-enhanced MRI. Material and Methods Pre- and post-contrast DWI (b = 0 and b = 1000 s/mm2) were acquired in 47 patients. Measured ADC values, pre- and post-contrast T2 signal intensity (T2 SI) and contrast-to-noise ratio (CNR) were compared with Wilcoxon signed-rank and rank-sum test ( P < 0.05). Results Post-contrast ADC was reduced only in malignant lesions (−34%), T2 SI was reduced both in malignant (−50%) and benign (−36%) lesions. Post-contrast CNR was reduced in all groups except for benign lesions. Conclusion Gadolinium-based contrast agent causes a significant reduction in ADC values of malignant breast lesions.

scholarly journals Differentiation of clinically benign and malignant breast lesions using diffusion-weighted imaging

2002 ◽  
Vol 16 (2) ◽  
pp. 172-178 ◽  
Author(s):  
Yong Guo ◽  
You-Quan Cai ◽  
Zu-Long Cai ◽  
Yuan-Gui Gao ◽  
Ning-Yu An ◽  
...  
Keyword(s):  
Diffusion Weighted Imaging ◽  
Breast Lesions ◽  
Diffusion Weighted ◽  
Malignant Breast

scholarly journals Investigation of the optimal b-value to detect breast tumors with diffusion weighted imaging by 1.5-T MRI

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Takayuki Tamura ◽  
Shigeru Murakami ◽  
Kumiko Naito ◽  
Tamaki Yamada ◽  
Takashi Fujimoto ◽  
...  
Keyword(s):  
Diffusion Weighted Imaging ◽  
Breast Tumors ◽  
B Value ◽  
Diffusion Weighted

scholarly journals ADC-Based Stratification of Molecular Glioma Subtypes Using High b-Value Diffusion-Weighted Imaging

2021 ◽  
Vol 10 (16) ◽  
pp. 3451
Author(s):  
Nils C. Nuessle ◽  
Felix Behling ◽  
Ghazaleh Tabatabai ◽  
Salvador Castaneda Vega ◽  
Jens Schittenhelm ◽  
...  
Keyword(s):  
Diffusion Weighted Imaging ◽  
Mean Diffusivity ◽  
Area Under The Curve ◽  
B Value ◽  
Diffusion Kurtosis Imaging ◽  
B Values ◽  
High B Value ◽  
Diffusion Weighted ◽  
Apparent Diffusion

Purpose: To investigate the diagnostic performance of in vivo ADC-based stratification of integrated molecular glioma grades. Materials and methods: Ninety-seven patients with histopathologically confirmed glioma were evaluated retrospectively. All patients underwent pre-interventional MRI-examination including diffusion-weighted imaging (DWI) with implemented b-values of 500, 1000, 1500, 2000, and 2500 s/mm2. Apparent Diffusion Coefficient (ADC), Mean Kurtosis (MK), and Mean Diffusivity (MD) maps were generated. The average values were compared among the molecular glioma subgroups of IDH-mutant and IDH-wildtype astrocytoma, and 1p/19q-codeleted oligodendroglioma. One-way ANOVA with post-hoc Games-Howell correction compared average ADC, MD, and MK values between molecular glioma groups. A Receiver Operating Characteristic (ROC) analysis determined the area under the curve (AUC). Results: Two b-value-dependent ADC-based evaluations presented statistically significant differences between the three molecular glioma sub-groups (p < 0.001, respectively). Conclusions: High-b-value ADC from preoperative DWI may be used to stratify integrated molecular glioma subgroups and save time compared to diffusion kurtosis imaging. Higher b-values of up to 2500 s/mm2 may present an important step towards increasing diagnostic accuracy compared to standard DWI protocol.

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