Use of blood pool agents with steady-state MRI to assess the vascular system

2017 ◽  
Vol 45 (6) ◽  
pp. 1559-1572 ◽  
Author(s):  
Avnesh S. Thakor ◽  
John Chung ◽  
Premal Patel ◽  
Anthony Chan ◽  
Amdad Ahmed ◽  
...  
Keyword(s):  
Steady State ◽  
Vascular System ◽  
Blood Pool ◽  
Blood Pool Agents

scholarly journals A Second Generation Mn-Porphyrin Dimer with a Twisted Linker as a Potential Blood Pool Agent for MRI: Tuning the Geometry and Binding with HSA

2020 ◽  
Vol 13 (10) ◽  
pp. 282
Author(s):  
Hanlin Liu ◽  
Weiran Cheng ◽  
Shili Dong ◽  
David Feng Xu ◽  
Keith Tang ◽  
...  
Keyword(s):  
Vascular System ◽  
Time Window ◽  
Molecular Geometry ◽  
Blood Pool ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Vis Spectroscopy ◽  
Blood Pool Agents ◽  
Chemical Strategy

Blood-pool agents (BPAs) are MRI contrast agents (CAs) characterized by their long circulation in the vascular system to provide an extended time window for high-resolution MR angiography (MRA). Prolonged vascular retention, however, impedes the excretion of BPAs. Therefore, chemical strategy to regulate the balance between retention and clearance is important to reach optimal pharmacokinetics. We recently developed MnP2, the first Mn(III)-porphyrin (MnP) based BPA. MnP2 shows high T1 relaxivity (r1) and high affinity to human serum albumin (HSA) that leads to up to 48-h vascular retention in rats. However, upon albumin binding, the r1 is decreased. To modulate vascular retention time and plasma r1, a regioisomer of MnP2, m-MnP2, was synthesized. The free m-MnP2 exhibits lower r1 than that of MnP2 at magnetic fields above 2 MHz, which agrees with their relative hydrodynamic sizes. The HSA binding of m-MnP2 was evaluated using UV-Vis spectroscopy and found to have tuned-down affinity in comparison with MnP2. Upon HSA binding, the protein complex of m-MnP2 exhibits an r1 of 11.8 mM−1 s−1 at 3 T, which is higher than that of MnP2 bound to HSA. Taken together, this demonstrated the role of molecular geometry in optimizing the pharmacokinetics of albumin-targeting BPAs.

Comparison of CT contrast blood pool agents for in-vivo 3D angiography using MicroCT

2008 ◽  
Author(s):  
Christian Wietholt ◽  
Ji Li ◽  
Bulent Aydogan ◽  
Stephen L. Archer ◽  
Tijana Rajh ◽  
...  
Keyword(s):  
Blood Pool ◽  
3D Angiography ◽  
Blood Pool Agents ◽  
Ct Contrast

Improved mapping of pharmacologically induced neuronal activation using superparamagnetic iron blood pool agents

NeuroImage ◽  
2000 ◽  
Vol 11 (5) ◽  
pp. S570
Author(s):  
Y.I. Chen ◽  
J.B. Mandeville ◽  
T.V. Nguyen ◽  
F. Cavagna ◽  
B.G. Jenkins
Keyword(s):  
Blood Pool ◽  
Neuronal Activation ◽  
Blood Pool Agents

Blood Pool Agents for MRA

1998 ◽  
Vol 15 (02) ◽  
pp. 215-222 ◽  
Author(s):  
E. Yucel ◽  
Randall Lauffer
Keyword(s):  
Blood Pool ◽  
Blood Pool Agents

scholarly journals Improved mapping of pharmacologically induced neuronal activation using the IRON technique with superparamagnetic blood pool agents

2001 ◽  
Vol 14 (5) ◽  
pp. 517-524 ◽  
Author(s):  
Yin-Ching I. Chen ◽  
Joseph B. Mandeville ◽  
Tuong V. Nguyen ◽  
Anjali Talele ◽  
Friedrich Cavagna ◽  
...  
Keyword(s):  
Blood Pool ◽  
Neuronal Activation ◽  
Blood Pool Agents
Sign in / Sign up

Export Citation Format

Share Document