scholarly journals Improved mapping of pharmacologically induced neuronal activation using the IRON technique with superparamagnetic blood pool agents

2001 ◽  
Vol 14 (5) ◽  
pp. 517-524 ◽  
Author(s):  
Yin-Ching I. Chen ◽  
Joseph B. Mandeville ◽  
Tuong V. Nguyen ◽  
Anjali Talele ◽  
Friedrich Cavagna ◽  
...  
Keyword(s):  
Blood Pool ◽  
Neuronal Activation ◽  
Blood Pool Agents

Improved mapping of pharmacologically induced neuronal activation using superparamagnetic iron blood pool agents

NeuroImage ◽  
2000 ◽  
Vol 11 (5) ◽  
pp. S570
Author(s):  
Y.I. Chen ◽  
J.B. Mandeville ◽  
T.V. Nguyen ◽  
F. Cavagna ◽  
B.G. Jenkins
Keyword(s):  
Blood Pool ◽  
Neuronal Activation ◽  
Blood Pool Agents

Comparison of CT contrast blood pool agents for in-vivo 3D angiography using MicroCT

2008 ◽  
Author(s):  
Christian Wietholt ◽  
Ji Li ◽  
Bulent Aydogan ◽  
Stephen L. Archer ◽  
Tijana Rajh ◽  
...  
Keyword(s):  
Blood Pool ◽  
3D Angiography ◽  
Blood Pool Agents ◽  
Ct Contrast

Blood Pool Agents for MRA

1998 ◽  
Vol 15 (02) ◽  
pp. 215-222 ◽  
Author(s):  
E. Yucel ◽  
Randall Lauffer
Keyword(s):  
Blood Pool ◽  
Blood Pool Agents

scholarly journals Biological effects of MRI contrast agents: gadolinium retention, potential mechanisms and a role for phosphorus

2017 ◽  
Vol 375 (2107) ◽  
pp. 20170180 ◽  
Author(s):  
Joel Garcia ◽  
Stephen Z. Liu ◽  
Angelique Y. Louie
Keyword(s):  
Molecular Imaging ◽  
Contrast Agents ◽  
Biological Effects ◽  
Blood Pool ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Treatment Regimens ◽  
Gadolinium Retention ◽  
Magnetic Resonance Imaging Mri ◽  
Blood Pool Agents

No discussion of challenges for chemistry in molecular imaging would be complete without addressing the elephant in the room—which is that the purest of chemical compounds needs to interact with a biological system in a manner that does not perturb normal biology while still providing efficacious feedback to assist in diagnosis of disease. In the past decade, magnetic resonance imaging (MRI) agents long considered inert have produced adverse effects in certain patient populations under certain treatment regimens. More recently, inert blood pool agents have been found to deposit in the brain. Release of free metal is often suspected as the culprit but that hypothesis has yet to be validated. In addition, even innocuous agents can cause painful side effects during injection in some patients. In this brief review, we summarize known biological effects for gadolinium- and iron-based MRI contrast agents, and discuss some of the potential mechanisms for the observed biological effects, including the potential role of phosphorus imbalance, related to kidney disease or cancer, in destabilizing gadolinium-based chelates and precipitating free gadolinium. This article is part of the themed issue ‘Challenges for chemistry in molecular imaging’.

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