Contrast-enhanced susceptibility weighted imaging with ultrasmall superparamagnetic iron oxide improves the detection of tumor vascularity in a hepatocellular carcinoma nude mouse model

2016 ◽  
Vol 44 (2) ◽  
pp. 288-295 ◽  
Author(s):  
Shuo-hui Yang ◽  
Jiang Lin ◽  
Fang Lu ◽  
Yuan-yuan Dai ◽  
Zhi-hong Han ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Iron Oxide ◽  
Mouse Model ◽  
Nude Mouse ◽  
Superparamagnetic Iron Oxide ◽  
Susceptibility Weighted Imaging ◽  
Tumor Vascularity ◽  
Nude Mouse Model ◽  
Ultrasmall Superparamagnetic Iron Oxide ◽  
Contrast Enhanced

scholarly journals Use of Ultrasmall Superparamagnetic Iron Oxide Enhanced Susceptibility Weighted Imaging and Mean Vessel Density Imaging to Monitor Antiangiogenic Effects of Sorafenib on Experimental Hepatocellular Carcinoma

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Shuohui Yang ◽  
Jiang Lin ◽  
Fang Lu ◽  
Zhihong Han ◽  
Caixia Fu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Iron Oxide ◽  
Superparamagnetic Iron Oxide ◽  
Treated Group ◽  
Vessel Density ◽  
Susceptibility Weighted Imaging ◽  
Sorafenib Treatment ◽  
Ultrasmall Superparamagnetic Iron Oxide ◽  
Novel Biomarkers ◽  
And Control

We investigated effectiveness of ultrasmall superparamagnetic iron oxide enhanced susceptibility weighted imaging (USPIO-enhanced SWI) and mean vessel density imaging (Q) in monitoring antiangiogenic effects of Sorafenib on orthotopic hepatocellular carcinoma (HCC). Thirty-five HCC xenografts were established. USPIO-enhanced SWI and Q were performed on a 1.5 T MR scanner at baseline, 7, 14, and 21 days after Sorafenib treatment. Intratumoral susceptibility signal intensity (ITSS) and Q were serially measured and compared between the treated (n = 15) and control groups (n = 15). Both ITSS and Q were significantly lower in the treated group at each time point (P < 0.05). Measurements in the treated group showed that ITSS persisted at 7 days (P = 0.669) and increased at 14 and 21 days (P < 0.05), while Q significantly declined at 7 days (P = 0.028) and gradually increased at 14 and 21 days. In the treated group, significant correlation was found between Q and histologic microvessel density (MVD) (r = 0.753, P < 0.001), and ITSS correlated well with MVD (r = 0.742, P = 0.002) after excluding the data from baseline. This study demonstrated that USPIO-enhanced SWI and Q could provide novel biomarkers for evaluating antiangiogenic effects of Sorafenib on HCC.

scholarly journals p38 MAPK Inhibition Reduces Aortic Ultrasmall Superparamagnetic Iron Oxide Uptake in a Mouse Model of Atherosclerosis

2008 ◽  
Vol 28 (2) ◽  
pp. 265-271 ◽  
Author(s):  
Joanne B. Morris ◽  
Alan R. Olzinski ◽  
Roberta E. Bernard ◽  
Karpagam Aravindhan ◽  
Rosanna C. Mirabile ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mouse Model ◽  
P38 Mapk ◽  
Superparamagnetic Iron Oxide ◽  
Ultrasmall Superparamagnetic Iron Oxide
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