An exploration of diffusion tensor eigenvector variability within human calf muscles

2015 ◽  
Vol 43 (1) ◽  
pp. 190-202 ◽  
Author(s):  
Conrad Rockel ◽  
Michael D. Noseworthy
Keyword(s):  
Diffusion Tensor ◽  
Human Calf ◽  
Calf Muscles

Human calf muscles changes after strength training as revealed by diffusion tensor imaging

2019 ◽  
Vol 59 (5) ◽  
Author(s):  
Daniele Bruschetta ◽  
Giuseppe Anastasi ◽  
Veronica Andronaco ◽  
Filippo Cascio ◽  
Giuseppina Rizzo ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Strength Training ◽  
Diffusion Tensor ◽  
Human Calf ◽  
Calf Muscles

scholarly journals High Inter-Rater Reliability of Manual Segmentation and Volume-Based Tractography in Healthy and Dystrophic Human Calf Muscle

Diagnostics ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1521
Author(s):  
Johannes Forsting ◽  
Marlena Rohm ◽  
Martijn Froeling ◽  
Anne-Katrin Güttsches ◽  
Matthias Vorgerd ◽  
...  
Keyword(s):  
Diffusion Tensor ◽  
Neuromuscular Diseases ◽  
Healthy Controls ◽  
Manual Segmentation ◽  
Rater Reliability ◽  
Additional Information ◽  
Diffusion Parameters ◽  
Coefficients Of Variation ◽  
Human Calf ◽  
Calf Muscles

Background: Muscle diffusion tensor imaging (mDTI) is a promising surrogate biomarker in the evaluation of muscular injuries and neuromuscular diseases. Since mDTI metrics are known to vary between different muscles, separation of different muscles is essential to achieve muscle-specific diffusion parameters. The commonly used technique to assess DTI metrics is parameter maps based on manual segmentation (MSB). Other techniques comprise tract-based approaches, which can be performed in a previously defined volume. This so-called volume-based tractography (VBT) may offer a more robust assessment of diffusion metrics and additional information about muscle architecture through tract properties. The purpose of this study was to assess DTI metrics of human calf muscles calculated with two segmentation techniques—MSB and VBT—regarding their inter-rater reliability in healthy and dystrophic calf muscles. Methods: 20 healthy controls and 18 individuals with different neuromuscular diseases underwent an MRI examination in a 3T scanner using a 16-channel Torso XL coil. DTI metrics were assessed in seven calf muscles using MSB and VBT. Coefficients of variation (CV) were calculated for both techniques. MSB and VBT were performed by two independent raters to assess inter-rater reliability by ICC analysis and Bland-Altman plots. Next to analysis of DTI metrics, the same assessments were also performed for tract properties extracted with VBT. Results: For both techniques, low CV were found for healthy controls (≤13%) and neuromuscular diseases (≤17%). Significant differences between methods were found for all diffusion metrics except for λ1. High inter-rater reliability was found for both MSB and VBT (ICC ≥ 0.972). Assessment of tract properties revealed high inter-rater reliability (ICC ≥ 0.974). Conclusions: Both segmentation techniques can be used in the evaluation of DTI metrics in healthy controls and different NMD with low rater dependency and high precision but differ significantly from each other. Our findings underline that the same segmentation protocol must be used to ensure comparability of mDTI data.

3D Microstructural Fiber Tracking of the Human Calf Muscles in Individuals With and Without Type 2 Diabetes during Rest and Exercise

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 632-P
Author(s):  
MASOUD EDALATI ◽  
CHRISTOPHER J. SORENSEN ◽  
MARY HASTINGS ◽  
MOHAMED A. ZAYED ◽  
MICHAEL J. MUELLER ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fiber Tracking ◽  
Human Calf ◽  
Calf Muscles ◽  
Rest And Exercise

Diffusion Tensor Magnetic Resonance Imaging of the Human Calf

2008 ◽  
Vol 43 (9) ◽  
pp. 612-618 ◽  
Author(s):  
Nadja Saupe ◽  
Lawrence M. White ◽  
Marshall S. Sussman ◽  
Andrea Kassner ◽  
George Tomlinson ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Diffusion Tensor ◽  
Resonance Imaging ◽  
Human Calf

A Comparison of Temperature Rise in Human Calf Muscles following Applications of Underwater and Topical Gel Ultrasound

1993 ◽  
Vol 17 (5) ◽  
pp. 247-251 ◽  
Author(s):  
David O. Draper ◽  
Scott Sunderland ◽  
Donald T. Kirkendall ◽  
Mark Ricard
Keyword(s):  
Temperature Rise ◽  
Topical Gel ◽  
Human Calf ◽  
Calf Muscles

scholarly journals Two-pedal ergometer for in vivo MRS studies of human calf muscles

2001 ◽  
Vol 46 (5) ◽  
pp. 1000-1005 ◽  
Author(s):  
Maria Pia Francescato ◽  
Valentina Cettolo
Keyword(s):  
Human Calf ◽  
Calf Muscles ◽  
In Vivo Mrs

scholarly journals Quantification and Monitoring of the Effect of Botulinum Toxin A on Paretic Calf Muscles of Children With Cerebral Palsy With MRI: A Preliminary Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Claudia Weidensteiner ◽  
Philipp Madoerin ◽  
Xeni Deligianni ◽  
Tanja Haas ◽  
Oliver Bieri ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Botulinum Toxin ◽  
Diffusion Tensor ◽  
Botulinum Toxin A ◽  
Toxin A ◽  
Muscle Properties ◽  
Mean Values ◽  
Spin Echo Sequence ◽  
Fat Fraction ◽  
Calf Muscles

Background: Muscles from patients with cerebral palsy (CP) are often spastic and form contractures that limit the range of motion. Injections of botulinum toxin A (BTX) into the calf muscles are an important treatment for functional equinus; however, improvement in gait function is not always achieved. BTX is also used to test muscle weakening for risk evaluation of muscle lengthening surgery. Our aim was to assess the effect of BTX over time on calf muscle properties in pediatric CP patients with MRI.Material and Methods: Six toe-walking CP patients (mean age 11.6 years) with indication for lengthening surgery were prospectively enrolled and received BTX injections into the gastrocnemius and soleus muscles. MRI scans at 3T of the lower legs and clinical examinations were performed pre-BTX, 6 weeks (6w), and 12 weeks (12w) post-BTX. A fat-suppressed 2D multi-spin-echo sequence was used to acquire T2 maps and for segmentation. Fat fraction maps were calculated from 3D multi-echo Dixon images. Diffusion tensor imaging (DTI) with a 2D echo-planar imaging (EPI) sequence yielded maps of the mean apparent diffusion coefficient (ADC) and of the fractional anisotropy (FA). Hyperintense regions of interest (ROIs) on the T2-weighted (T2w) images at 6w were segmented in treated muscles. Mean values of T2, fat fraction, ADC, and FA were calculated in hyperintense ROIs and in reference ROIs in non-treated muscles.Results: Hyperintensity on T2w scans and increased T2 (group mean ± standard deviation: 35 ± 1 ms pre-BTX, 45 ± 2 ms at 6w, and 44 ± 2 ms at 12w) were observed in all patients at the injection sites. The T2 increase was spatially limited to parts of the injected muscles. FA increased (0.30 ± 0.03 pre-BTX, 0.34 ± 0.02 at 6w, and 0.36 ± 0.03 at 12w) while ADC did not change in hyperintense ROIs, indicating a BTX-induced increase in extracellular space and a simultaneous decrease of muscle fiber diameter. Fat fraction showed a trend for increase at 12w. Mean values in reference ROIs remained unchanged.Conclusion: MRI showed limited spatial distribution of the BTX-induced effects in pediatric CP patients. It could be a promising non-invasive tool for future studies to test BTX treatment protocols.

Hadamard spectroscopic imaging technique as applied to study human calf muscles

1992 ◽  
Vol 25 (2) ◽  
pp. 349-354 ◽  
Author(s):  
Gadi Goelman ◽  
Glenn Walter ◽  
John S. Leigh
Keyword(s):  
Imaging Technique ◽  
Spectroscopic Imaging ◽  
Human Calf ◽  
Calf Muscles
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