Subcortical gray matter segmentation and voxel-based analysis using transverse relaxation and quantitative susceptibility mapping with application to multiple sclerosis

2015 ◽  
Vol 42 (6) ◽  
pp. 1601-1610 ◽  
Author(s):  
Dana Cobzas ◽  
Hongfu Sun ◽  
Andrew J. Walsh ◽  
R. Marc Lebel ◽  
Gregg Blevins ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Susceptibility Mapping ◽  
Quantitative Susceptibility Mapping ◽  
Transverse Relaxation

Improved Detection of Cortical Gray Matter Involvement in Multiple Sclerosis with Quantitative Susceptibility Mapping

2015 ◽  
Vol 22 (11) ◽  
pp. 1427-1432 ◽  
Author(s):  
Shingo Kakeda ◽  
Koichiro Futatsuya ◽  
Satoru Ide ◽  
Keita Watanabe ◽  
Mari Miyata ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Susceptibility Mapping ◽  
Quantitative Susceptibility Mapping ◽  
Cortical Gray Matter

scholarly journals Quantitative susceptibility mapping (QSM) of white matter multiple sclerosis lesions: Interpreting positive susceptibility and the presence of iron

2014 ◽  
Vol 74 (2) ◽  
pp. 564-570 ◽  
Author(s):  
Cynthia Wisnieff ◽  
Sriram Ramanan ◽  
John Olesik ◽  
Susan Gauthier ◽  
Yi Wang ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Susceptibility Mapping ◽  
Quantitative Susceptibility Mapping

Spin echo transverse relaxation and atrophy in multiple sclerosis deep gray matter: A two-year longitudinal study

2016 ◽  
Vol 22 (9) ◽  
pp. 1133-1143 ◽  
Author(s):  
Md Nasir Uddin ◽  
R Marc Lebel ◽  
Peter Seres ◽  
Gregg Blevins ◽  
Alan H Wilman
Keyword(s):  
Multiple Sclerosis ◽  
Disease Severity ◽  
Globus Pallidus ◽  
Gray Matter ◽  
Spin Echo ◽  
Transverse Relaxation Rate ◽  
Transverse Relaxation ◽  
Longitudinal Mri ◽  
Deep Gray Matter ◽  
Relapsing Remitting Multiple Sclerosis

Background: Deep gray matter (DGM) is affected in relapsing–remitting multiple sclerosis (RRMS) and may be studied using short-term longitudinal MRI. Objective: To investigate two-year changes in spin-echo transverse relaxation rate (R2) and atrophy in DGM, and its relationship with disease severity in RRMS patients. Methods: Twenty six RRMS patients and 26 matched controls were imaged at 4.7 T. Multiecho spin-echo R2 maps and atrophy measurements were obtained in DGM at baseline and two-year follow-up. Differences between MRI measures and correlations to disease severity were examined. Results: After two years, mean R2 values in the globus pallidus and pulvinar increased by ~4% ( p<0.001) in patients and <1.7% in controls. Two-year changes in R2 showed significant correlation to disease severity in the globus pallidus, pulvinar, substantia nigra, and thalamus. Multiple regression of the two-year R2 difference using these four DGM structures as variables, yielded high correlation with disease severity ( r=0.83, p<0.001). Two-year changes in volume and R2 showed significant correlation only for the globus pallidus in multiple sclerosis (MS) ( p<0.05). Conclusions: Two-year difference R2 measurements in DGM correlate to disease severity in MS. R2 mapping and atrophy measurements over two years can be used to identify changes in DGM in MS.

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