Intravoxel incoherent motion MRI evaluation for the staging of liver fibrosis in a rat model

2014 ◽  
Vol 42 (2) ◽  
pp. 331-339 ◽  
Author(s):  
Genwen Hu ◽  
Queenie Chan ◽  
Xianyue Quan ◽  
Xuhui Zhang ◽  
Yufa Li ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Rat Model ◽  
Intravoxel Incoherent Motion ◽  
Motion Mri ◽  
Mri Evaluation

scholarly journals Using IVIM-MRI and R2⁎ Mapping to Differentiate Early Stage Liver Fibrosis in a Rat Model of Radiation-Induced Liver Fibrosis

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Jianye Liang ◽  
Xiubao Song ◽  
Zeyu Xiao ◽  
Hanwei Chen ◽  
Changzheng Shi ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Rat Model ◽  
Early Stage ◽  
Blue Staining ◽  
Pathological Examination ◽  
Strong Positive Correlation ◽  
Radiation Induced ◽  
Motion Mri ◽  
Right Lobe ◽  
D Values

Rationale and Objectives. To investigate the utility of intravoxel incoherent motion MRI (IVIM-MRI) and R2⁎ mapping in diagnosing early stage liver fibrosis in a radiation-induced rat model. Materials and Methods. Thirty rats were randomly divided into three groups with 10 rats in each group. Liver fibrosis was induced by exposure of right lobe of liver in each animal to 20 Gy of radiation. MRI examination was conducted at baseline, one month, two months, and three months after radiation using T1WI, T2WI, IVIM-DWI, and R2⁎ sequences. The pathological examination included hematoxylin eosin, masson trichrome, and prussian blue staining. D, D⁎, f, and R2⁎ values were measured in both left and right lobes for quantitative analysis. Results. Regarding the surviving 23 rats, eight rats were diagnosed with stage F0, ten with stage F1, and five with stage F2 liver fibrosis using METAVIR Scores. The D values of right lobes decreased (P<0.05), and R2⁎ values increased (P<0.01) significantly as fibrosis levels increased. But there was no statistical difference in D⁎ (P=0.970) and f values (P=0.079). R2⁎ value showed a strong positive correlation (r=0.819, P<0.001), while D value showed a negative correlation with fibrosis stages (r=-0.424, P<0.001). D⁎ (r=0.029, P=0.744) and f values (r=-0.055, P=0.536) were poorly correlated with fibrosis levels. Conclusion. IVIM-MRI and R2⁎ mapping are useful techniques for evaluating the severity of liver fibrosis in a radiation-induced rat model, and R2⁎ value is the most sensitive parameter in detecting early stage fibrosis.

Intravoxel incoherent motion MRI for liver fibrosis assessment: a pilot study

2014 ◽  
Vol 56 (12) ◽  
pp. 1428-1436 ◽  
Author(s):  
Sae Rom Chung ◽  
Seung Soo Lee ◽  
Namkug Kim ◽  
Eun Sil Yu ◽  
Eunki Kim ◽  
...  
Keyword(s):  
Pilot Study ◽  
Liver Fibrosis ◽  
Intravoxel Incoherent Motion ◽  
Motion Mri

Use of intravoxel incoherent motion MRI to assess renal fibrosis in a rat model of unilateral ureteral obstruction

2016 ◽  
Vol 44 (3) ◽  
pp. 698-706 ◽  
Author(s):  
Xiang-Ran Cai ◽  
Juan Yu ◽  
Qing-Chun Zhou ◽  
Bin Du ◽  
You-Zhen Feng ◽  
...  
Keyword(s):  
Rat Model ◽  
Ureteral Obstruction ◽  
Renal Fibrosis ◽  
Unilateral Ureteral Obstruction ◽  
Intravoxel Incoherent Motion ◽  
Motion Mri

Development of imaging biomarker for esophageal cancer using intravoxel incoherent motion MRI

Esophagus ◽  
2021 ◽  
Author(s):  
Ryoya Mizumachi ◽  
Koichi Hayano ◽  
Atsushi Hirata ◽  
Gaku Ohira ◽  
Shunsuke Imanishi ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Intravoxel Incoherent Motion ◽  
Imaging Biomarker ◽  
Motion Mri

scholarly journals Intravoxel incoherent motion MRI for the initial characterization of non-fatty non-vascular soft tissue tumors

2020 ◽  
Vol 101 (4) ◽  
pp. 245-255 ◽  
Author(s):  
P.A. Gondim Teixeira ◽  
L. Simon ◽  
F. Sirveaux ◽  
B. Marie ◽  
M. Louis ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Tumors ◽  
Intravoxel Incoherent Motion ◽  
Initial Characterization ◽  
Motion Mri

scholarly journals Spectral Diffusion Analysis of Intravoxel Incoherent Motion MRI in Cerebral Small Vessel Disease

2020 ◽  
Vol 51 (4) ◽  
Author(s):  
Sau May Wong ◽  
Walter H. Backes ◽  
Gerhard S. Drenthen ◽  
C. Eleana Zhang ◽  
Paulien H.M. Voorter ◽  
...  
Keyword(s):  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Spectral Diffusion ◽  
Small Vessel ◽  
Intravoxel Incoherent Motion ◽  
Vessel Disease ◽  
Diffusion Analysis ◽  
Motion Mri

F.N.10 PHARMACOLOGICAL ANTAGONISM OF ENDOCANNABINOID CB1 RECEPTOR AMELIORATES LIVER FIBROSIS IN A RAT MODEL OF ADVANCED CIRRHOSIS

2010 ◽  
Vol 42 ◽  
pp. S36-S37
Author(s):  
F.A. Giannone ◽  
M. Domenicali ◽  
M. Baldassarre ◽  
G. Di Pompo ◽  
M. Bernardi ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Rat Model ◽  
Cb1 Receptor ◽  
Advanced Cirrhosis

Triggered intravoxel incoherent motion MRI for the assessment of calf muscle perfusion during isometric intermittent exercise

2018 ◽  
Vol 31 (6) ◽  
pp. e3922 ◽  
Author(s):  
Alfonso Mastropietro ◽  
Simone Porcelli ◽  
Marcello Cadioli ◽  
Letizia Rasica ◽  
Elisa Scalco ◽  
...  
Keyword(s):  
Intermittent Exercise ◽  
Calf Muscle ◽  
Intravoxel Incoherent Motion ◽  
Muscle Perfusion ◽  
Motion Mri
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