MR pulse wave velocity increases with age faster in the thoracic aorta than in the abdominal aorta

2014 ◽  
Vol 41 (3) ◽  
pp. 765-772 ◽  
Author(s):  
Daniel G.H. Devos ◽  
Ernst Rietzschel ◽  
Catherine Heyse ◽  
Pieter Vandemaele ◽  
Luc Van Bortel ◽  
...  
Keyword(s):  
Pulse Wave Velocity ◽  
Thoracic Aorta ◽  
Wave Velocity ◽  
Abdominal Aorta ◽  
Pulse Wave

Comparison of pulse-wave velocity in different aortic regions in relation to the extent and severity of atherosclerosis between young and older Kurosawa and Kusanagi-Hypercholesterolemic (KHC) rabbits

2000 ◽  
Vol 99 (5) ◽  
pp. 393-404 ◽  
Author(s):  
Shin-ichiro KATSUDA ◽  
Masamitsu HASEGAWA ◽  
Masahiko KUSANAGI ◽  
Tsuyoshi SHIMIZU
Keyword(s):  
Elastic Modulus ◽  
Pulse Wave Velocity ◽  
Aortic Arch ◽  
Thoracic Aorta ◽  
Wave Velocity ◽  
Abdominal Aorta ◽  
Aortic Wall ◽  
Pulse Wave ◽  
Age Groups ◽  
Ascending Aorta

The present study was performed to investigate the effects of the development of atherosclerosis on foot-to-foot pulse-wave velocity (PWV) from the ascending aorta to different positions along the aorta in Kurosawa and Kusanagi-Hypercholesterolemic (KHC) rabbits aged 10–12 and 22–24 months old, in relation to the percentage fractional lesioned area (PFLA) in different aortic regions through which the pulse wave travels, as well as the rheological and pathohistological properties of the aortic wall. PWV, when measured in the KHC rabbit from the ascending aorta to each aortic position, showed the highest value on passage through the aortic arch, decreased with conduction to the distal thoracic aorta, reached the minimal value on passage to the distal thoracic aorta or to the middle abdominal aorta in the 10–12- and 22–24-month-old animals respectively, and increased gradually on conduction to the iliac artery. PWV at all aortic regions examined was significantly greater in the 22–24-month-old than in the 10–12-month-old KHC rabbits. PFLA, when measured in the aortic region from the ascending aorta to each aortic position, was maximal in the aortic arch and decreased gradually towards the peripheral aorta in both age groups. PFLA in the 22–24-month-old group was significantly greater than that in the 10–12-month-old group in all aortic regions examined. The atherosclerotic aortic wall showed a significantly lower elastic modulus in the young KHC rabbits compared with age-matched normal rabbits. A significantly higher elastic modulus was observed in the older KHC rabbits compared with that in the younger animals of both strains, associated with the progression of sclerosis. These findings indicate that the increase in PWV is due mainly to an increase with aging in the extent and severity of atherosclerosis in vessels in which the pulse wave travels.

scholarly journals Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hemodialysis Patients with Atrial Fibrillation: the Valkyrie Study

2019 ◽  
Vol 31 (1) ◽  
pp. 186-196 ◽  
Author(s):  
An S. De Vriese ◽  
Rogier Caluwé ◽  
Lotte Pyfferoen ◽  
Dirk De Bacquer ◽  
Koen De Boeck ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Pulse Wave Velocity ◽  
Thoracic Aorta ◽  
Wave Velocity ◽  
Vitamin K ◽  
Pulse Wave ◽  
Vitamin K2 ◽  
Favorable Effect ◽  
Bleeding Complications ◽  
Multicenter Randomized Controlled Trial

BackgroundVitamin K antagonists (VKAs), although commonly used to reduce thromboembolic risk in atrial fibrillation, have been incriminated as probable cause of accelerated vascular calcification (VC) in patients on hemodialysis. Functional vitamin K deficiency may further contribute to their susceptibility for VC. We investigated the effect of vitamin K status on VC progression in 132 patients on hemodialysis with atrial fibrillation treated with VKAs or qualifying for anticoagulation.MethodsPatients were randomized to VKAs with target INR 2–3, rivaroxaban 10 mg daily, or rivaroxaban 10 mg daily plus vitamin K2 2000 µg thrice weekly during 18 months. Systemic dp-ucMGP levels were quantified to assess vascular vitamin K status. Cardiac and thoracic aorta calcium scores and pulse wave velocity were measured to evaluate VC progression.ResultsBaseline dp-ucMGP was severely elevated in all groups. Initiation or continuation of VKAs further increased dp-ucMGP, whereas levels decreased in the rivaroxaban group and to a larger extent in the rivaroxaban+vitamin K2 group, but remained nevertheless elevated. Changes in coronary artery, thoracic aorta, and cardiac valve calcium scores and pulse wave velocity were not significantly different among the treatment arms. All cause death, stroke, and cardiovascular event rates were similar between the groups. Bleeding outcomes were not significantly different, except for a lower number of life-threatening and major bleeding episodes in the rivaroxaban arms versus the VKA arm.ConclusionsWithdrawal of VKAs and high-dose vitamin K2 improve vitamin K status in patients on hemodialysis, but have no significant favorable effect on VC progression. Severe bleeding complications may be lower with rivaroxaban than with VKAs.

An innovative numerical approach to resolve the pulse wave velocity in a healthy thoracic aorta model

2012 ◽  
Vol 17 (5) ◽  
pp. 461-473
Author(s):  
An-Shik Yang ◽  
Chih-Yung Wen ◽  
Li-Yu Tseng ◽  
Chih-Chieh Chiang ◽  
Wen-Yih Isaac Tseng ◽  
...  
Keyword(s):  
Pulse Wave Velocity ◽  
Thoracic Aorta ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Numerical Approach

scholarly journals Does Pulse Wave Velocity Reflect Elasticity of Abdominal Aorta of Hypertensive Fowl?

2006 ◽  
Vol 20 (5) ◽  
Author(s):  
YIMU YANG ◽  
Ciro A Ruiz‐Feria ◽  
Donald B Thomason ◽  
Hiroko Nishimura
Keyword(s):  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Abdominal Aorta ◽  
Pulse Wave

Comparison of Echotracking and Magnetic Resonance Assessment of Abdominal Aorta Distensibility and Relationships with Pulse Wave Velocity

2011 ◽  
Vol 37 (12) ◽  
pp. 1970-1976 ◽  
Author(s):  
Cristina Giannattasio ◽  
Francesca Cesana ◽  
Silvia Maestroni ◽  
Alessandra Salvioni ◽  
Alessandro Maloberti ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Abdominal Aorta ◽  
Pulse Wave

Changes in segmental pulse wave velocity of the thoracic aorta with age and left ventricular remodelling. An MRI 4D flow study

2020 ◽  
Vol 38 (1) ◽  
pp. 118-126 ◽  
Author(s):  
Gilles Soulat ◽  
Umit Gencer ◽  
Nadjia Kachenoura ◽  
Olivier Villemain ◽  
Emmanuel Messas ◽  
...  
Keyword(s):  
Pulse Wave Velocity ◽  
Thoracic Aorta ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Left Ventricular ◽  
Ventricular Remodelling ◽  
4D Flow ◽  
Left Ventricular Remodelling ◽  
Flow Study
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