Longitudinal changes in MRI markers in a reversible unilateral ureteral obstruction mouse model: Preliminary experience

2013 ◽  
Vol 39 (4) ◽  
pp. 835-841 ◽  
Author(s):  
Muhammad E. Haque ◽  
Tammy Franklin ◽  
Ujala Bokhary ◽  
Liby Mathew ◽  
Bradley K. Hack ◽  
...  
Keyword(s):  
Mouse Model ◽  
Ureteral Obstruction ◽  
Unilateral Ureteral Obstruction ◽  
Longitudinal Changes

The antifibrotic and anti-inflammatory effects of icariin on the kidney in a unilateral ureteral obstruction mouse model

Phytomedicine ◽  
2019 ◽  
Vol 59 ◽  
pp. 152917 ◽  
Author(s):  
Hsin‐An Chen ◽  
Chang-Mu Chen ◽  
Siao-Syun Guan ◽  
Chih-Kang Chiang ◽  
Cheng-Tien Wu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Ureteral Obstruction ◽  
Unilateral Ureteral Obstruction ◽  
Anti Inflammatory

A UNILATERAL URETERAL OBSTRUCTION MOUSE MODEL IS APPLIED TO INVESTIGATE THE PATHOPHYSIOLOGY OF OBSTRUCTED URETERS

2009 ◽  
Vol 181 (4S) ◽  
pp. 721-721 ◽  
Author(s):  
Kwadwo Owusu-Ofori ◽  
Eric Wilkinson ◽  
William S Mellon ◽  
Stephen Y Nakada
Keyword(s):  
Mouse Model ◽  
Ureteral Obstruction ◽  
Unilateral Ureteral Obstruction

scholarly journals Interleukin-10 deficiency aggravates kidney inflammation and fibrosis in the unilateral ureteral obstruction mouse model

2013 ◽  
Vol 93 (7) ◽  
pp. 801-811 ◽  
Author(s):  
Yuanmeng Jin ◽  
Ruijie Liu ◽  
Jingyuan Xie ◽  
Huabao Xiong ◽  
John Cijiang He ◽  
...  
Keyword(s):  
Mouse Model ◽  
Ureteral Obstruction ◽  
Interleukin 10 ◽  
Unilateral Ureteral Obstruction

scholarly journals Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction

2017 ◽  
Vol 187 (11) ◽  
pp. 2413-2429 ◽  
Author(s):  
Stephanie Schwalm ◽  
Sandra Beyer ◽  
Helena Frey ◽  
Riad Haceni ◽  
Georgios Grammatikos ◽  
...  
Keyword(s):  
Mouse Model ◽  
Ureteral Obstruction ◽  
Sphingosine Kinase ◽  
Unilateral Ureteral Obstruction ◽  
Kidney Fibrosis ◽  
Sphingosine Kinase 2

scholarly journals Protective effects of SKLB023 on a mouse model of unilateral ureteral obstruction by the modulation of gut microbiota

RSC Advances ◽  
2018 ◽  
Vol 8 (70) ◽  
pp. 40232-40242
Author(s):  
Yanhuan Feng ◽  
Lingzhi Li ◽  
Fan Guo ◽  
Yanping Li ◽  
Yan Liang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Gut Microbiota ◽  
Ureteral Obstruction ◽  
Renal Fibrosis ◽  
Unilateral Ureteral Obstruction ◽  
Protective Effects ◽  
Common Pathway ◽  
The Common

Renal fibrosis is the common pathway underlying the progression of CKD to ESRD and quantitative and qualitative alterations in gut microbiota are noted in patients with CKD. Our results indicated SKLB023 drives the alteration of gut microbiota to attenuate renal fibrosis.

Inhibition of CTCF-regulated miRNA-185-5p mitigates renal interstitial fibrosis of chronic kidney disease

Epigenomics ◽  
2021 ◽  
Author(s):  
Jiajun Zhou ◽  
Han Zhou ◽  
Yong Liu ◽  
Caixin Liu
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Mouse Model ◽  
Ureteral Obstruction ◽  
Interstitial Fibrosis ◽  
Unilateral Ureteral Obstruction ◽  
Renal Interstitial Fibrosis ◽  
Underlying Mechanisms

Aim: The present study aimed to elucidate the effect of CTCF on renal interstitial fibrosis in chronic kidney disease (CKD) and underlying mechanisms. Materials & methods: We measured NPHS2 expression and investigated its function in a unilateral ureteral obstruction-induced mouse model of CKD. Results: NPHS2 was poorly expressed in CKD mice. miR-185-5p targeted NPHS2 and reduced its expression, leading to increased α-SMA and COL I/III expression, increased renal interstitial fibrosis area and elevated phosphorylated vasodilator-stimulated phosphoprotein/vasodilator-stimulated phosphoprotein ratio. Cotreatment with CTCF downregulated miR-185-5p expression and abolished its effects in the CKD model. Conclusion: CTCF suppressed miR-185-5p and upregulated its target NPHS2, with a net effect of alleviating renal interstitial fibrosis in CKD.

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