scholarly journals Huangkui Capsule Ameliorates Renal Fibrosis in a Unilateral Ureteral Obstruction Mouse Model Through TRPC6 Dependent Signaling Pathways

2020 ◽  
Vol 11 ◽  
Author(s):  
Li-fei Gu ◽  
Hai-tao Ge ◽  
Lei Zhao ◽  
Yu-jing Wang ◽  
Fan Zhang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Signaling Pathways ◽  
Ureteral Obstruction ◽  
Renal Fibrosis ◽  
Unilateral Ureteral Obstruction

scholarly journals Protective effects of SKLB023 on a mouse model of unilateral ureteral obstruction by the modulation of gut microbiota

RSC Advances ◽  
2018 ◽  
Vol 8 (70) ◽  
pp. 40232-40242
Author(s):  
Yanhuan Feng ◽  
Lingzhi Li ◽  
Fan Guo ◽  
Yanping Li ◽  
Yan Liang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Gut Microbiota ◽  
Ureteral Obstruction ◽  
Renal Fibrosis ◽  
Unilateral Ureteral Obstruction ◽  
Protective Effects ◽  
Common Pathway ◽  
The Common

Renal fibrosis is the common pathway underlying the progression of CKD to ESRD and quantitative and qualitative alterations in gut microbiota are noted in patients with CKD. Our results indicated SKLB023 drives the alteration of gut microbiota to attenuate renal fibrosis.

scholarly journals The farnesoid X receptor agonist EDP‐305 reduces interstitial renal fibrosis in a mouse model of unilateral ureteral obstruction

2019 ◽  
Vol 33 (6) ◽  
pp. 7103-7112 ◽  
Author(s):  
Shen Li ◽  
Sarani Ghoshal ◽  
Mozhdeh Sojoodi ◽  
Gunisha Arora ◽  
Ricard Masia ◽  
...  
Keyword(s):  
Mouse Model ◽  
Ureteral Obstruction ◽  
Renal Fibrosis ◽  
Receptor Agonist ◽  
Unilateral Ureteral Obstruction ◽  
Farnesoid X Receptor

Redox signaling pathways in unilateral ureteral obstruction (UUO)-induced renal fibrosis

2021 ◽  
Author(s):  
Ana Karina Aranda-Rivera ◽  
Alfredo Cruz-Gregorio ◽  
Omar Emiliano Aparicio-Trejo ◽  
Ariadna Jazmín Ortega-Lozano ◽  
José Pedraza-Chaverri
Keyword(s):  
Signaling Pathways ◽  
Ureteral Obstruction ◽  
Renal Fibrosis ◽  
Redox Signaling ◽  
Unilateral Ureteral Obstruction

The antifibrotic and anti-inflammatory effects of icariin on the kidney in a unilateral ureteral obstruction mouse model

Phytomedicine ◽  
2019 ◽  
Vol 59 ◽  
pp. 152917 ◽  
Author(s):  
Hsin‐An Chen ◽  
Chang-Mu Chen ◽  
Siao-Syun Guan ◽  
Chih-Kang Chiang ◽  
Cheng-Tien Wu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Ureteral Obstruction ◽  
Unilateral Ureteral Obstruction ◽  
Anti Inflammatory

scholarly journals NLRP3 Deficiency Attenuates Renal Fibrosis and Ameliorates Mitochondrial Dysfunction in a Mouse Unilateral Ureteral Obstruction Model of Chronic Kidney Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Honglei Guo ◽  
Xiao Bi ◽  
Ping Zhou ◽  
Shijian Zhu ◽  
Wei Ding
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Mitochondrial Dysfunction ◽  
Ureteral Obstruction ◽  
Renal Fibrosis ◽  
Unilateral Ureteral Obstruction ◽  
Tubulointerstitial Fibrosis ◽  
Mitochondrial Morphology ◽  
Glomerular Injury ◽  
Matrix Deposition

Background and Aims. The nucleotide-binding domain and leucine-rich repeat containing PYD-3 (NLRP3) inflammasome has been implicated in the pathogenesis of chronic kidney disease (CKD); however, its exact role in glomerular injury and tubulointerstitial fibrosis is still undefined. The present study was performed to identify the function of NLRP3 in modulating renal injury and fibrosis and the potential involvement of mitochondrial dysfunction in the murine unilateral ureteral obstruction (UUO) model of CKD. Methods. Employing wild-type (WT) and NLRP3−/− mice with or without UUO, we evaluated renal structure, tissue injury, and mitochondrial ultrastructure, as well as expression of some vital molecules involved in the progression of fibrosis, apoptosis, inflammation, and mitochondrial dysfunction. Results. The severe glomerular injury and tubulointerstitial fibrosis induced in WT mice by UUO was markedly attenuated in NLRP3−/− mice as evidenced by blockade of extracellular matrix deposition, decreased cell apoptosis, and phenotypic alterations. Moreover, NLRP3 deletion reversed UUO-induced impairment of mitochondrial morphology and function. Conclusions. NLRP3 deletion ameliorates mitochondrial dysfunction and alleviates renal fibrosis in a murine UUO model of CKD.

scholarly journals The Role of Apelin on the Alleviative Effect of Angiotensin Receptor Blocker in Unilateral Ureteral Obstruction-Induced Renal Fibrosis

Nephron Extra ◽  
2012 ◽  
Vol 2 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Masashi Nishida ◽  
Yasuko Okumura ◽  
Tatsujiro Oka ◽  
Kentaro Toiyama ◽  
Seiichiro Ozawa ◽  
...  
Keyword(s):  
Ureteral Obstruction ◽  
Renal Fibrosis ◽  
Angiotensin Receptor Blocker ◽  
Unilateral Ureteral Obstruction ◽  
Receptor Blocker ◽  
Angiotensin Receptor
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