Effects of age and sex on the concentrations of glutamate and glutamine in the human brain

2013 ◽  
Vol 38 (6) ◽  
pp. 1480-1487 ◽  
Author(s):  
Sven Hädel ◽  
Christoph Wirth ◽  
Michael Rapp ◽  
Jürgen Gallinat ◽  
Florian Schubert
Keyword(s):  
Human Brain ◽  
Age And Sex

scholarly journals Age and sex dependent variability of type 2 dopamine receptors in the human brain: A large-scale PET cohort

2021 ◽  
Author(s):  
Tuulia Malén ◽  
Tomi Karjalainen ◽  
Janne Isojärvi ◽  
Aki Vehtari ◽  
Paul-Christian Bürkner ◽  
...  
Keyword(s):  
Human Brain ◽  
Large Scale ◽  
Movement Control ◽  
Heterogeneous Data ◽  
Small Sample ◽  
Cross Sectional ◽  
Psychiatric Conditions ◽  
Small Sample Sizes ◽  
Age And Sex

BACKGROUND: The dopamine system contributes to a multitude of functions ranging from reward and motivation to learning and movement control, making it a key component in goal-directed behavior. Altered dopaminergic function is observed in neurological and psychiatric conditions. Numerous factors have been proposed to influence dopamine function, but due to small sample sizes and heterogeneous data analysis methods in previous studies their specific and joint contributions remain unresolved. METHODS: In this cross-sectional register-based study we investigated how age, sex, body mass index (BMI), as well as cerebral hemisphere and regional volume influence striatal type 2 dopamine receptor (D2R) availability in the human brain. We analyzed a large historical dataset (n=156, 120 males and 36 females) of [11C]raclopride PET scans performed between 2004 and 2018. RESULTS: Striatal D2R availability decreased through age for both sexes and was higher in females versus males throughout age. BMI and striatal D2R availability were weakly associated. There was no consistent lateralization of striatal D2R. The observed effects were independent of regional volumes. These results were validated using two different spatial normalization methods, and the age and sex effects also replicated in an independent sample (n=135). CONCLUSIONS: D2R density is dependent on age and sex, which may contribute to the vulnerability of neurological and psychiatric conditions involving altering D2R expression.

Proton spectroscopy of human brain: Effects of age and sex

1994 ◽  
Vol 18 (6) ◽  
pp. 995-1004 ◽  
Author(s):  
H.Cecil Charles ◽  
Francois Lazeyras ◽  
K.Ranga Rama Krishnan ◽  
Orest B. Boyko ◽  
Linda J. Patterson ◽  
...  
Keyword(s):  
Human Brain ◽  
Proton Spectroscopy ◽  
Age And Sex

In Vivo Measurement of Dopamine Receptors in Human Brain by Positron Emission Tomography Age and Sex Differences

1988 ◽  
Vol 515 (1 Central Deter) ◽  
pp. 203-214 ◽  
Author(s):  
DEAN F. WONG ◽  
EMMANUEL P. BROUSSOLLE ◽  
GARY WAND ◽  
VICTOR VILLEMAGNE ◽  
ROBERT F. DANNALS ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Sex Differences ◽  
Human Brain ◽  
Dopamine Receptors ◽  
Emission Tomography ◽  
In Vivo Measurement ◽  
Positron Emission ◽  
Age And Sex

Age and sex differences in human brain mu opioid receptor binding measured by PET

1996 ◽  
Vol 39 (7) ◽  
pp. 605-606 ◽  
Author(s):  
J.K. Zubieta ◽  
Y.R. Smith ◽  
H.T. Ravert ◽  
R.F. Dannals ◽  
J.J. Frost
Keyword(s):  
Sex Differences ◽  
Human Brain ◽  
Opioid Receptor ◽  
Receptor Binding ◽  
Mu Opioid Receptor ◽  
Mu Opioid ◽  
Age And Sex ◽  
Opioid Receptor Binding

scholarly journals Neuroepigenetic signatures of age and sex in the living human brain

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Tonya M. Gilbert ◽  
Nicole R. Zürcher ◽  
Mary C. Catanese ◽  
Chieh-En J. Tseng ◽  
Maria A. Di Biase ◽  
...  
Keyword(s):  
Human Brain ◽  
Age And Sex

Do age and sex impact on the absolute cell numbers of human brain regions?

2015 ◽  
Vol 221 (7) ◽  
pp. 3547-3559 ◽  
Author(s):  
Ana V. Oliveira-Pinto ◽  
Carlos H. Andrade-Moraes ◽  
Lays M. Oliveira ◽  
Danielle R. Parente-Bruno ◽  
Raquel M. Santos ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Regions ◽  
Cell Numbers ◽  
The Absolute ◽  
Age And Sex

Language processing is not a race against time

2016 ◽  
Vol 39 ◽  
Author(s):  
Giosuè Baggio ◽  
Carmelo M. Vicario
Keyword(s):  
Information Processing ◽  
Human Brain ◽  
Language Processing ◽  
Cognitive Functions ◽  
Memory Systems ◽  
Language System ◽  
Moderating Factors

AbstractWe agree with Christiansen & Chater (C&C) that language processing and acquisition are tightly constrained by the limits of sensory and memory systems. However, the human brain supports a range of cognitive functions that mitigate the effects of information processing bottlenecks. The language system is partly organised around these moderating factors, not just around restrictions on storage and computation.

Structural and Chemical Studies of Pathological Fibers in Human Neurofibrillary Degeneration

1985 ◽  
Vol 43 ◽  
pp. 726-729
Author(s):  
K.S. Kosik ◽  
L.K. Duffy ◽  
S. Bakalis ◽  
C. Abraham ◽  
D.J. Selkoe
Keyword(s):  
Monoclonal Antibodies ◽  
Alzheimer Disease ◽  
Human Brain ◽  
Neurofibrillary Tangles ◽  
Morphological Analysis ◽  
High Specificity ◽  
Cytoskeletal Proteins ◽  
Neuritic Plaque ◽  
Protein Chemistry ◽  
Chemical Studies

The major structural lesions of the human brain during aging and in Alzheimer disease (AD) are the neurofibrillary tangles (NFT) and the senile (neuritic) plaque. Although these fibrous alterations have been recognized by light microscopists for almost a century, detailed biochemical and morphological analysis of the lesions has been undertaken only recently. Because the intraneuronal deposits in the NFT and the plaque neurites and the extraneuronal amyloid cores of the plaques have a filamentous ultrastructure, the neuronal cytoskeleton has played a prominent role in most pathogenetic hypotheses.The approach of our laboratory toward elucidating the origin of plaques and tangles in AD has been two-fold: the use of analytical protein chemistry to purify and then characterize the pathological fibers comprising the tangles and plaques, and the use of certain monoclonal antibodies to neuronal cytoskeletal proteins that, despite high specificity, cross-react with NFT and thus implicate epitopes of these proteins as constituents of the tangles.

Sign in / Sign up

Export Citation Format

Share Document