scholarly journals Liver diffusivity in healthy volunteers and patients with chronic liver disease: Comparison of breathhold and free-breathing techniques

2011 ◽  
Vol 35 (1) ◽  
pp. 103-109 ◽  
Author(s):  
Mamak Eatesam ◽  
Susan M. Noworolski ◽  
Phyllis C. Tien ◽  
Michelle Nystrom ◽  
Jennifer L. Dodge ◽  
...  
Keyword(s):  
Liver Disease ◽  
Healthy Volunteers ◽  
Chronic Liver Disease ◽  
Free Breathing ◽  
Chronic Liver ◽  
Breathing Techniques

scholarly journals Time intensity curves of Sonazoid in portal vein in the patients with chronic liver disease and in healthy volunteers

Kanzo ◽  
2009 ◽  
Vol 50 (10) ◽  
pp. 593-594 ◽  
Author(s):  
Sachiyo Kogita ◽  
Yasuharu Imai ◽  
Yasushi Seki ◽  
Tomoyuki Uto ◽  
Tetsuya Iwasaki ◽  
...  
Keyword(s):  
Liver Disease ◽  
Portal Vein ◽  
Healthy Volunteers ◽  
Chronic Liver Disease ◽  
Chronic Liver

Quantification of hepatic perfusion and hepatocyte function with dynamic gadoxetic acid-enhanced MRI in patients with chronic liver disease

2018 ◽  
Vol 132 (7) ◽  
pp. 813-824 ◽  
Author(s):  
Benjamin Leporq ◽  
Jean-Luc Daire ◽  
Catherine M. Pastor ◽  
Pierre Deltenre ◽  
Christine Sempoux ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Dynamic Mri ◽  
Free Breathing ◽  
Compartment Model ◽  
Chronic Liver ◽  
Parameter Analysis ◽  
Gadoxetic Acid ◽  
Hepatic Perfusion ◽  
Enhanced Mri

The purpose of the present study was to develop and perform initial validation of dynamic MRI enhanced with gadoxetic acid as hepatobiliary contrast agent to quantify hepatic perfusion and hepatocyte function in patients with chronic liver disease. Free-breathing, dynamic gadoxetic acid-enhanced MRI was performed at 3.0 T using a 3D time-resolved angiography sequence with stochastic trajectories during 38 min. A dual-input three-compartment model was developed to derive hepatic perfusion and hepatocyte function parameters. Method feasibility was assessed in 23 patients with biopsy-proven chronic liver disease. Parameter analysis could be performed in 21 patients (91%). The hepatocyte function parameters were more discriminant than the perfusion parameters to differentiate between patients with minimal fibrosis (METAVIR F0–F1), intermediate fibrosis (F2–F3) and cirrhosis (F4). The areas under the receiver operating characteristic curves (ROCs) to diagnose significant fibrosis (METAVIR F ≥ 2) were: 0.95 (95% CI: 0.87–1; P<0.001) for biliary efflux, 0.88 (95% CI: 0.73–1; P<0.01) for sinusoidal backflux, 0.81 (95% CI: 0.61–1; P<0.05) for hepatocyte uptake fraction and 0.75 (95% CI: 0.54–1; P<0.05) for hepatic perfusion index (HPI), respectively. These initial results in patients with chronic liver diseases show that simultaneous quantification of hepatic perfusion and hepatocyte function is feasible with free breathing dynamic gadoxetic acid-enhanced MRI. Hepatocyte function parameters may be relevant to assess liver fibrosis severity.

Genetic predictors of spontaneous viral elimination or chronic liver disease in hepatitis C infection

2001 ◽  
Vol 120 (5) ◽  
pp. A7-A7
Author(s):  
S ROSS ◽  
S MASCHERETTI ◽  
H HINRICHSEN ◽  
P BUGGISCH ◽  
U FOELSCH ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hepatitis C ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Hepatitis C Infection ◽  
Genetic Predictors

Functional effects of methylthioadenosine phosphorylase (MTAP) expression in chronic liver disease

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
B Czech ◽  
D Valletta ◽  
K Dettmer ◽  
M Müller ◽  
A Bosserhoff ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Methylthioadenosine Phosphorylase
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