3 Tesla and 7 Tesla MRI of multiple sclerosis cortical lesions

2010 ◽  
Vol 32 (4) ◽  
pp. 971-977 ◽  
Author(s):  
Emma C. Tallantyre ◽  
Paul S. Morgan ◽  
Jennifer E. Dixon ◽  
Ali Al-Radaideh ◽  
Matthew J. Brookes ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
3 Tesla ◽  
7 Tesla ◽  
Cortical Lesions ◽  
7 Tesla Mri

A Method for Analysis of Cortical Lesions on 7-Tesla MRI in Multiple Sclerosis (P03.064)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. P03.064-P03.064
Author(s):  
D. Harrison ◽  
J. Oh ◽  
C. Jones ◽  
J. Hua ◽  
E. Wood ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
7 Tesla ◽  
Cortical Lesions ◽  
7 Tesla Mri

scholarly journals Improved in vivo detection of cortical lesions in multiple sclerosis using double inversion recovery MR imaging at 3 Tesla

2010 ◽  
Vol 20 (7) ◽  
pp. 1675-1683 ◽  
Author(s):  
Birgit Simon ◽  
Stephan Schmidt ◽  
Carsten Lukas ◽  
Jürgen Gieseke ◽  
Frank Träber ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Mr Imaging ◽  
Inversion Recovery ◽  
3 Tesla ◽  
Double Inversion Recovery ◽  
Cortical Lesions ◽  
In Vivo Detection

scholarly journals Clinical value of (dedicated) 3 Tesla and 7 Tesla MRI for cT1 glottic carcinoma: A feasibility study

2019 ◽  
Vol 4 (1) ◽  
pp. 95-101
Author(s):  
Sylvia L. van Egmond ◽  
Bernard M.D. Vonck ◽  
Johanna J. Bluemink ◽  
Frank A. Pameijer ◽  
Jan Willem Dankbaar ◽  
...  
Keyword(s):  
Feasibility Study ◽  
3 Tesla ◽  
7 Tesla ◽  
Glottic Carcinoma ◽  
Clinical Value ◽  
7 Tesla Mri

scholarly journals Profiles of cortical inflammation in multiple sclerosis by 11C-PBR28 MR-PET and 7 Tesla imaging

2019 ◽  
Vol 26 (12) ◽  
pp. 1497-1509 ◽  
Author(s):  
Elena Herranz ◽  
Céline Louapre ◽  
Constantina Andrada Treaba ◽  
Sindhuja T Govindarajan ◽  
Russell Ouellette ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Disease Burden ◽  
Relative Difference ◽  
Tracer Uptake ◽  
Microglia Activation ◽  
Inactive Disease ◽  
7 Tesla ◽  
Cortical Lesion ◽  
Cortical Lesions ◽  
Cortical Areas

Background: Neuroinflammation with microglia activation is thought to be closely related to cortical multiple sclerosis (MS) lesion pathogenesis. Objective: Using 11C-PBR28 and 7 Tesla (7T) imaging, we assessed in 9 relapsing–remitting multiple sclerosis (RRMS) and 10 secondary progressive multiple sclerosis (SPMS) patients the following: (1) microglia activation in lesioned and normal-appearing cortex, (2) cortical lesion inflammatory profiles, and (3) the relationship between neuroinflammation and cortical integrity. Methods: Mean 11C-PBR28 uptake was measured in focal cortical lesions, cortical areas with 7T quantitative T2* (q-T2*) abnormalities, and normal-appearing cortex. The relative difference in cortical 11C-PBR28 uptake between patients and 14 controls was used to classify cortical lesions as either active or inactive. Disease burden was investigated according to cortical lesion inflammatory profiles. The relation between q-T2* and 11C-PBR28 uptake along the cortex was assessed. Results: 11C-PBR28 uptake was abnormally high in cortical lesions in RRMS and SPMS; in SPMS, tracer uptake was significantly increased also in normal-appearing cortex. 11C-PBR28 uptake and q-T2* correlated positively in many cortical areas, negatively in some regions. Patients with high cortical lesion inflammation had worse clinical outcome and higher intracortical lesion burden than patients with low inflammation. Conclusion: 11C-PBR28 and 7T imaging reveal distinct profiles of cortical inflammation in MS, which are related to disease burden.

A clinically feasible 7-Tesla protocol for the identification of cortical lesions in Multiple Sclerosis

2020 ◽  
Vol 30 (8) ◽  
pp. 4586-4594 ◽  
Author(s):  
Sirio Cocozza ◽  
Mirco Cosottini ◽  
Alessio Signori ◽  
Lazar Fleysher ◽  
Mohamed Mounir El Mendili ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
7 Tesla ◽  
Cortical Lesions

scholarly journals Quantitative 7-Tesla Imaging of Cortical Myelin Changes in Early Multiple Sclerosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Valeria Barletta ◽  
Elena Herranz ◽  
Constantina A. Treaba ◽  
Ambica Mehndiratta ◽  
Russell Ouellette ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Quantitative Mri ◽  
7 Tesla ◽  
Cortical Lesion ◽  
Healthy Controls ◽  
Cortical Lesions ◽  
Lesion Analysis ◽  
Cortical Map ◽  
The Brain

Cortical demyelination occurs early in multiple sclerosis (MS) and relates to disease outcome. The brain cortex has endogenous propensity for remyelination as proven from histopathology study. In this study, we aimed at characterizing cortical microstructural abnormalities related to myelin content by applying a novel quantitative MRI technique in early MS. A combined myelin estimation (CME) cortical map was obtained from quantitative 7-Tesla (7T) T2* and T1 acquisitions in 25 patients with early MS and 19 healthy volunteers. Cortical lesions in MS patients were classified based on their myelin content by comparison with CME values in healthy controls as demyelinated, partially demyelinated, or non-demyelinated. At follow-up, we registered changes in cortical lesions as increased, decreased, or stable CME. Vertex-wise analysis compared cortical CME in the normal-appearing cortex in 25 MS patients vs. 19 healthy controls at baseline and investigated longitudinal changes at 1 year in 10 MS patients. Measurements from the neurite orientation dispersion and density imaging (NODDI) diffusion model were obtained to account for cortical neurite/dendrite loss at baseline and follow-up. Finally, CME maps were correlated with clinical metrics. CME was overall low in cortical lesions (p = 0.03) and several normal-appearing cortical areas (p < 0.05) in the absence of NODDI abnormalities. Individual cortical lesion analysis revealed, however, heterogeneous CME patterns from extensive to partial or absent demyelination. At follow-up, CME overall decreased in cortical lesions and non-lesioned cortex, with few areas showing an increase (p < 0.05). Cortical CME maps correlated with processing speed in several areas across the cortex. In conclusion, CME allows detection of cortical microstructural changes related to coexisting demyelination and remyelination since the early phases of MS, and shows to be more sensitive than NODDI and relates to cognitive performance.

scholarly journals No association between cortical lesions and leptomeningeal enhancement on 7-Tesla MRI in multiple sclerosis

2019 ◽  
Vol 26 (2) ◽  
pp. 165-176 ◽  
Author(s):  
Mehrnaz Ighani ◽  
Samuel Jonas ◽  
Izlem Izbudak ◽  
Seongjin Choi ◽  
Alfonso Lema-Dopico ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cortical Thickness ◽  
7 Tesla ◽  
Focal Lesion ◽  
Cortical Lesions ◽  
Leptomeningeal Enhancement ◽  
Meningeal Inflammation ◽  
Cortical Gray Matter ◽  
Inflammatory Processes ◽  
Magnetic Resonance Imaging Mri

Background: Autopsy data suggest a causative link between meningeal inflammation and cortical lesions (CLs) in multiple sclerosis (MS). Objective: To use leptomeningeal enhancement (LME) and CLs on 7-Tesla (7T) magnetic resonance imaging (MRI) to investigate associations between meningeal inflammation and cortical pathology. Methods: Forty-one participants with MS underwent 7T MRI of the brain. CLs and foci of LME were quantified. Results: All MS participants had CLs; 27 (65.8%) had >1 focus of LME. Except for hippocampal CL count (ρ = 0.32 with spread/fill-sulcal pattern LME, p = 0.042), no significant correlations were seen between LME and CLs. Mean cortical thickness correlated with the number of LME foci (ρ = –0.43, p = 0.005). Participants with relapsing–remitting multiple sclerosis (RRMS) showed no correlation with neocortical CLs, but significant correlations were seen between LME and hippocampal lesion count (ρ = 0.39, p = 0.030), normalized cortical gray matter (GM) volume (ρ = –0.49, p = 0.005), and mean cortical thickness (ρ = –0.59, p < 0.001). Conclusion: This study supports a relationship between LME and cortical GM atrophy but does not support an association of LME and neocortical CLs. This may indicate that meningeal inflammation is involved with neurodegenerative inflammatory processes, rather than focal lesion development.

Increase in the iron content of the substantia nigra and red nucleus in multiple sclerosis and clinically isolated syndrome: A 7 Tesla MRI study

2014 ◽  
Vol 41 (4) ◽  
pp. 1065-1070 ◽  
Author(s):  
Anna I. Blazejewska ◽  
Ali M. Al-Radaideh ◽  
Sam Wharton ◽  
Su Yin Lim ◽  
Richard W. Bowtell ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Substantia Nigra ◽  
Iron Content ◽  
Red Nucleus ◽  
Clinically Isolated Syndrome ◽  
7 Tesla ◽  
7 Tesla Mri ◽  
Mri Study
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