scholarly journals Magnetic resonance techniques for the in vivo assessment of multiple sclerosis pathology: Consensus report of the white matter study group

2005 ◽  
Vol 21 (6) ◽  
pp. 669-675 ◽  
Author(s):  
Massimo Filippi ◽  
Andrea Falini ◽  
Douglas L. Arnold ◽  
Franz Fazekas ◽  
Oded Gonen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Magnetic Resonance ◽  
Study Group ◽  
Consensus Report ◽  
In Vivo Assessment

In vivo gradients of thalamic damage in paediatric multiple sclerosis: a window into pathology

Brain ◽  
2020 ◽  
Author(s):  
Ermelinda De Meo ◽  
Loredana Storelli ◽  
Lucia Moiola ◽  
Angelo Ghezzi ◽  
Pierangelo Veggiotti ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Magnetic Resonance ◽  
Fractional Anisotropy ◽  
Mean Diffusivity ◽  
White Matter Lesions ◽  
Healthy Controls ◽  
Paediatric Multiple Sclerosis ◽  
Multiple Sclerosis Patients

Abstract The thalamus represents one of the first structures affected by neurodegenerative processes in multiple sclerosis. A greater thalamic volume reduction over time, on its CSF side, has been described in paediatric multiple sclerosis patients. However, its determinants and the underlying pathological changes, likely occurring before this phenomenon becomes measurable, have never been explored. Using a multiparametric magnetic resonance approach, we quantified, in vivo, the different processes that can involve the thalamus in terms of focal lesions, microstructural damage and atrophy in paediatric multiple sclerosis patients and their distribution according to the distance from CSF/thalamus interface and thalamus/white matter interface. In 70 paediatric multiple sclerosis patients and 26 age- and sex-matched healthy controls, we tested for differences in thalamic volume and quantitative MRI metrics—including fractional anisotropy, mean diffusivity and T1/T2-weighted ratio—in the whole thalamus and in thalamic white matter, globally and within concentric bands originating from CSF/thalamus interface. In paediatric multiple sclerosis patients, the relationship of thalamic abnormalities with cortical thickness and white matter lesions was also investigated. Compared to healthy controls, patients had significantly increased fractional anisotropy in whole thalamus (f2 = 0.145; P = 0.03), reduced fractional anisotropy (f2 = 0.219; P = 0.006) and increased mean diffusivity (f2 = 0.178; P = 0.009) in thalamic white matter and a trend towards a reduced thalamic volume (f2 = 0.027; P = 0.058). By segmenting the whole thalamus and thalamic white matter into concentric bands, in paediatric multiple sclerosis we detected significant fractional anisotropy abnormalities in bands nearest to CSF (f2 = 0.208; P = 0.002) and in those closest to white matter (f2 range = 0.183–0.369; P range = 0.010–0.046), while we found significant mean diffusivity (f2 range = 0.101–0.369; P range = 0.018–0.042) and T1/T2-weighted ratio (f2 = 0.773; P = 0.001) abnormalities in thalamic bands closest to CSF. The increase in fractional anisotropy and decrease in mean diffusivity detected at the CSF/thalamus interface correlated with cortical thickness reduction (r range = −0.27–0.34; P range = 0.004–0.028), whereas the increase in fractional anisotropy detected at the thalamus/white matter interface correlated with white matter lesion volumes (r range = 0.24–0.27; P range = 0.006–0.050). Globally, our results support the hypothesis of heterogeneous pathological processes, including retrograde degeneration from white matter lesions and CSF-mediated damage, leading to thalamic microstructural abnormalities, likely preceding macroscopic tissue loss. Assessing thalamic microstructural changes using a multiparametric magnetic resonance approach may represent a target to monitor the efficacy of neuroprotective strategies early in the disease course.

scholarly journals In Vivo Assessment of Brain White Matter Inflammation in Multiple Sclerosis with 18F-PBR111 PET

2014 ◽  
Vol 55 (7) ◽  
pp. 1112-1118 ◽  
Author(s):  
A. Colasanti ◽  
Q. Guo ◽  
N. Muhlert ◽  
P. Giannetti ◽  
M. Onega ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Brain White Matter ◽  
In Vivo Assessment

scholarly journals In vivo assessment of neuroinflammation in progressive multiple sclerosis: a proof of concept study with [18F]DPA714 PET

2018 ◽  
Vol 15 (1) ◽  
Author(s):  
Marloes H. J. Hagens ◽  
Sandeep V. Golla ◽  
Martijn T. Wijburg ◽  
Maqsood Yaqub ◽  
Dennis Heijtel ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Progressive Multiple Sclerosis ◽  
Proof Of Concept ◽  
Concept Study ◽  
In Vivo Assessment

scholarly journals Feasibility of Magnetic Resonance Fingerprinting on Aging MRI Hardware

Tomography ◽  
2021 ◽  
Vol 8 (1) ◽  
pp. 10-21
Author(s):  
Brendan Lee Eck ◽  
Kecheng Liu ◽  
Wei-ching Lo ◽  
Yun Jiang ◽  
Vikas Gulani ◽  
...  
Keyword(s):  
White Matter ◽  
Magnetic Resonance ◽  
Coefficient Of Variation ◽  
Strong Correlation ◽  
Advanced Imaging ◽  
Partial Explanation ◽  
In Vivo Experiments ◽  
Percent Difference ◽  
Relevant Range

The purpose of this work is to evaluate the feasibility of performing magnetic resonance fingerprinting (MRF) on older and lower-performance MRI hardware as a means to bring advanced imaging to the aging MRI install base. Phantom and in vivo experiments were performed on a 1.5T Siemens Aera (installed 2015) and 1.5T Siemens Symphony (installed 2002). A 2D spiral MRF sequence for simultaneous T1/T2/M0 mapping was implemented on both scanners with different gradient trajectories to accommodate system specifications. In phantom, for T1/T2 values in a physiologically relevant range (T1: 195–1539 ms; T2: 20–267 ms), scanners had strong correlation (R2 > 0.999) with average absolute percent difference of 8.1% and 10.1%, respectively. Comparison of the two trajectories on the newer scanner showed differences of 2.6% (T1) and 10.9% (T2), suggesting a partial explanation of the observed inter-scanner bias. Inter-scanner agreement was better when the same trajectory was used, with differences of 6.0% (T1) and 4.0% (T2). Intra-scanner coefficient of variation (CV) of T1 and T2 estimates in phantom were <2.0% and in vivo were ≤3.5%. In vivo inter-scanner white matter CV was 4.8% (T1) and 5.1% (T2). White matter measurements on the aging scanner after two months were consistent, with differences of 1.9% (T1) and 3.9% (T2). In conclusion, MRF is feasible on an aging MRI scanner and required only changes to the gradient trajectory.

scholarly journals Development and Validation of Noninvasive Magnetic Resonance Relaxometry for the In Vivo Assessment of Tissue-Engineered Graft Oxygenation

2016 ◽  
Vol 22 (11) ◽  
pp. 1009-1017 ◽  
Author(s):  
Samuel A. Einstein ◽  
Bradley P. Weegman ◽  
Meri T. Firpo ◽  
Klearchos K. Papas ◽  
Michael Garwood
Keyword(s):  
Magnetic Resonance ◽  
Development And Validation ◽  
In Vivo Assessment
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