scholarly journals The effect of brain tumor angiogenesis on the in vivo relationship between the gradient-echo relaxation rate change (?R2*) and contrast agent (MION) dose

2003 ◽  
Vol 18 (4) ◽  
pp. 397-403 ◽  
Author(s):  
Arvind P. Pathak ◽  
Scott D. Rand ◽  
Kathleen M. Schmainda
Keyword(s):  
Brain Tumor ◽  
Contrast Agent ◽  
Relaxation Rate ◽  
Tumor Angiogenesis ◽  
Rate Change ◽  
Gradient Echo

In vivo CEST MR imaging of U87 mice brain tumor angiogenesis using targeted LipoCEST contrast agent at 7 T

2012 ◽  
Vol 69 (1) ◽  
pp. 179-187 ◽  
Author(s):  
Julien Flament ◽  
Françoise Geffroy ◽  
Christelle Medina ◽  
Caroline Robic ◽  
Jean-François Mayer ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Mr Imaging ◽  
Contrast Agent ◽  
Tumor Angiogenesis ◽  
Mice Brain

scholarly journals RGD-Targeted Ultrasound Contrast Agent for Longitudinal Assessment of Hep-2 Tumor Angiogenesis In Vivo

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0149075 ◽  
Author(s):  
Qiao Hu ◽  
Xiao-Yan Wang ◽  
Li-Ke Kang ◽  
Hai-Ming Wei ◽  
Chun-Mei Xu ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Tumor Angiogenesis ◽  
Ultrasound Contrast Agent ◽  
Longitudinal Assessment ◽  
Ultrasound Contrast ◽  
Targeted Ultrasound

19F molecular MR imaging for detection of brain tumor angiogenesis: in vivo validation using targeted PFOB nanoparticles

Angiogenesis ◽  
2012 ◽  
Vol 16 (1) ◽  
pp. 171-179 ◽  
Author(s):  
Céline Giraudeau ◽  
Françoise Geffroy ◽  
Sébastien Mériaux ◽  
Fawzi Boumezbeur ◽  
Philippe Robert ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Mr Imaging ◽  
Tumor Angiogenesis ◽  
In Vivo Validation

Assessing Tumor Angiogenesis with Computed Tomography and a Novel Nanoparticle Contrast Agent in an In Vivo Model of Neuroblastoma

2014 ◽  
Vol 186 (2) ◽  
pp. 683
Author(s):  
A. Lakoma ◽  
K.B. Ghaghada ◽  
C. Adhikari ◽  
C.C. Kaffes ◽  
Y. Rojas ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Contrast Agent ◽  
Tumor Angiogenesis ◽  
In Vivo Model

scholarly journals Dual-targeted Contrast Agent for US Assessment of Tumor Angiogenesis in Vivo

Radiology ◽  
2008 ◽  
Vol 248 (3) ◽  
pp. 936-944 ◽  
Author(s):  
Jürgen K. Willmann ◽  
Amelie M. Lutz ◽  
Ramasamy Paulmurugan ◽  
Manishkumar R. Patel ◽  
Pauline Chu ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Tumor Angiogenesis ◽  
Targeted Contrast Agent

Novel Phospholipid-Based Labrasol Nanomicelles Loaded Flavonoids for Oral Delivery with Enhanced Penetration and Anti-Brain Tumor Efficiency

2020 ◽  
Vol 17 (3) ◽  
pp. 229-245
Author(s):  
Gang Wang ◽  
Junjie Wang ◽  
Rui Guan
Keyword(s):  
Drug Delivery ◽  
Brain Tumor ◽  
Oral Delivery ◽  
Safe Delivery ◽  
Drug Delivery Vehicles ◽  
Therapeutic Benefits ◽  
Delivery Vehicles ◽  
The Brain

Background: Owing to the rich anticancer properties of flavonoids, there is a need for their incorporation into drug delivery vehicles like nanomicelles for safe delivery of the drug into the brain tumor microenvironment. Objective: This study, therefore, aimed to prepare the phospholipid-based Labrasol/Pluronic F68 modified nano micelles loaded with flavonoids (Nano-flavonoids) for the delivery of the drug to the target brain tumor. Methods: Myricetin, quercetin and fisetin were selected as the initial drugs to evaluate the biodistribution and acute toxicity of the drug delivery vehicles in rats with implanted C6 glioma tumors after oral administration, while the uptake, retention, release in human intestinal Caco-2 cells and the effect on the brain endothelial barrier were investigated in Human Brain Microvascular Endothelial Cells (HBMECs). Results: The results demonstrated that nano-flavonoids loaded with myricetin showed more evenly distributed targeting tissues and enhanced anti-tumor efficiency in vivo without significant cytotoxicity to Caco-2 cells and alteration in the Trans Epithelial Electric Resistance (TEER). There was no pathological evidence of renal, hepatic or other organs dysfunction after the administration of nanoflavonoids, which showed no significant influence on cytotoxicity to Caco-2 cells. Conclusion: In conclusion, Labrasol/F68-NMs loaded with MYR and quercetin could enhance antiglioma effect in vitro and in vivo, which may be better tools for medical therapy, while the pharmacokinetics and pharmacodynamics of nano-flavonoids may ensure optimal therapeutic benefits.

Recombinant Snake Venom Cystatin Inhibits Tumor Angiogenesis in vitro and in vivo Associated with Downregulation of VEGF-A165, Flt-1 and bFGF

2013 ◽  
Vol 13 (4) ◽  
pp. 663-671 ◽  
Author(s):  
Qun Xie ◽  
Nanhong Tang ◽  
Rong Wan ◽  
Yuanlin Qi ◽  
Xu Lin ◽  
...  
Keyword(s):  
Snake Venom ◽  
Tumor Angiogenesis

In Vivo MRI Visualization of Acute Myocardial Ischemia and Reperfusion in Ferrets by the Persistent Action of the Contrast Agent Gd(BME-DTTA)

Circulation ◽  
1995 ◽  
Vol 92 (12) ◽  
pp. 3549-3559 ◽  
Author(s):  
Tamás Simor ◽  
Wen-Jang Chu ◽  
Lynne Johnson ◽  
Andras Safranko ◽  
Mark Doyle ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Contrast Agent ◽  
Acute Myocardial Ischemia ◽  
Ischemia And Reperfusion ◽  
Myocardial Ischemia And Reperfusion
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