Systemic lupus erythematosus: molecular cloning and analysis of 22 individual recombinant monoclonal kappa light chains specifically hydrolyzing human myelin basic protein

2015 ◽  
Vol 28 (10) ◽  
pp. 614-627 ◽  
Author(s):  
Anna M. Timofeeva ◽  
Valentina N. Buneva ◽  
Georgy A. Nevinsky
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Myelin Basic Protein ◽  
Molecular Cloning ◽  
Lupus Erythematosus ◽  
Basic Protein ◽  
Light Chains ◽  
Systemic Lupus ◽  
Kappa Light Chains

Systemic lupus erythematosus: molecular cloning and analysis of recombinant monoclonal kappa light chain NGTA1-Me-pro with two metalloprotease active centers

2016 ◽  
Vol 12 (12) ◽  
pp. 3556-3566 ◽  
Author(s):  
Anna M. Timofeeva ◽  
Valentina N. Buneva ◽  
Georgy A. Nevinsky
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Myelin Basic Protein ◽  
Molecular Cloning ◽  
Light Chain ◽  
Lupus Erythematosus ◽  
Basic Protein ◽  
Kappa Light Chain ◽  
Systemic Lupus ◽  
Active Centers

Monoclonal light chain (NGTA1-Me-pro) possessing two alternative active centers with metalloprotease activities specifically recognizing only myelin basic protein (MBP) was obtained. NGTA1-Me-pro demonstrated two pH optima (A), two optimal concentrations of Me2+ions (B), and twoKmvalues for MBP.

Anti-histone H1 IgGs from blood serum of systemic lupus erythematosus patients are capable of hydrolyzing histone H1 and myelin basic protein

2010 ◽  
Vol 23 (5) ◽  
pp. 495-502 ◽  
Author(s):  
Irina B. Magorivska ◽  
Rostyslav O. Bilyy ◽  
Anna M. Havrylyuk ◽  
Valentyna V. Chop'yak ◽  
Rostyslav S. Stoika ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Blood Serum ◽  
Myelin Basic Protein ◽  
Lupus Erythematosus ◽  
Basic Protein ◽  
Histone H1 ◽  
Systemic Lupus
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